Психологический стресс и ревматоидный артрит – интерференция патогенетических механизмов

Проанализированы молекулярные механизмы развития нормального и патологического нейроэндокринного и иммунного адаптивного ответа на психологический (ментальный) стресс с точки зрения его возможной провоцирующей роли в развитии ревматоидного артрита (РА). При детальном анализе выявляется синергизм механизмов, провоцирующих развитие патологического антистрессового адаптивного ответа и РА. Возможно, у лиц группы риска развития РА минимальные и малозаметные для индивидуума стрессовые ситуации, периодически провоцирующие продолжительную продукцию провоспалительных цитокинов, могут, в конце концов, привести к развитию ревматического заболевания.

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