Ингибиторы ИЛ23/ИЛ17 при иммуновоспалительных ревматических заболеваниях: новые горизонты
Аннотация
В последние годы большое внимание привлекают Th17-клетки, патологическая активация которых играет ведущую роль в развитии широкого спектра иммуновоспалительных заболеваний (ИВЗ) человека, включая ревматоидный артрит, псориаз, анкилозирующий спондилит, псориатический артрит, воспалительные заболевания кишечника и др. Это послужило стимулом для разработки новых генно-инженерных биологических препаратов и «малых» молекул, механизм действия которых основан на блокировании патологических эффектов интерлейкина 17 (ИЛ17), других связанных с активацией Th17-клеток цитокинов или сигнальных путей, регулирующих эффекты этих цитокинов. В обзоре обсуждаются современные представления о механизмах регуляции образования и функциональной активности цитокинов семейства ИЛ17, а также доказательства значения этих цитокинов в патогенезе ИВЗ.
Об авторах
Е. Л. Насонов
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»,
ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)
Россия
Россия
115522, Москва, Каширское шоссе, 34А
119991, Москва, ул. Трубецкая, 8, стр. 2
Т. В. Коротаева
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»
Россия
115522, Москва, Каширское шоссе, 34А
Россия
115522, Москва, Каширское шоссе, 34А
Т. В. Дубинина
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»
Россия
115522, Москва, Каширское шоссе, 34А
Россия
115522, Москва, Каширское шоссе, 34А
А. М. Лила
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»,
кафедра ревматологии ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России
Россия
Россия
115522, Москва, Каширское шоссе, 34А
125993, Москва, ул. Баррикадная, 2/1, стр. 1
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Для цитирования:
Насонов Е.Л., Коротаева Т.В., Дубинина Т.В., Лила А.М. Ингибиторы ИЛ23/ИЛ17 при иммуновоспалительных ревматических заболеваниях: новые горизонты. Научно-практическая ревматология. 2019;57(4):400-406. https://doi.org/10.14412/1995-4484-2019-400-406
For citation:
Nasonov E.L., Korotaeva T.V., Dubinina T.V., Lila A.M. IL-23/IL-17 INHIBITORS IN IMMUNOINFLAMMATORY RHEUMATIC DISEASES: NEW HORIZONS. Rheumatology Science and Practice. 2019;57(4):400-406. (In Russ.) https://doi.org/10.14412/1995-4484-2019-400-406
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