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Научно-практическая ревматология

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Системная красная волчанка: новые горизонты диагностики и терапии

https://doi.org/10.14412/1995-4484-2020-5-14

Аннотация

Системная красная волчанка (СКВ) — системное аутоиммунное ревматическое заболевание неизвестной этиологии, характеризующееся гиперпродукцией органонеспецифических аутоантител к различным компонентам клеточного ядра и развитием иммуновоспалительного повреждения внутренних органов. СКВ — прототип системной аутоиммунной патологии человека, относится к числу чрезвычайно гетерогенных заболеваний с точки зрения как клинических проявлений, так и генетической предрасположенности и механизмов патогенеза, что нередко затрудняет раннюю диагностику и не позволяет персонифицировать терапию. Несмотря на то что в XXI в. 15-летняя выживаемость при СКВ увеличилась до 85%, недостаточный контроль активности болезни, необходимость практически постоянного приема глюкокортикоидов (ГК) и иммуносупрессивных препаратов приводят к накоплению необратимых (accrul) повреждений внутренних органов и, как следствие, снижению качества жизни, инвалидности, социальной дезадаптации, преждевременной летальности. Рассматриваются новые диагностические критерии СКВ (EULAR/ACR, 2019), современные рекомендации по терапии СКВ (EULAR, 2019) и новые возможности фармакотерапии СКВ, основанные на расшифровке механизмов иммунопатогенеза этого заболевания.

Об авторах

С. К. Соловьев
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой
Россия

15522, Москва, Каширское шоссе, 34А


Конфликт интересов:

гонорары за консультационные услуги в области научной и педагогической деятельности (образовательные услуги, научные статьи, участие в экспертных советах, участие в исследованиях и др.)



Е. А. Асеева
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой
Россия

15522, Москва, Каширское шоссе, 34А


Конфликт интересов:

гонорары за консультационные услуги в области научной и педагогической деятельности (образовательные услуги, научные статьи, участие в экспертных советах, участие в исследованиях и др.)



Т. В. Попкова
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой
Россия

15522, Москва, Каширское шоссе, 34А


Конфликт интересов:

гонорары за консультационные услуги в области научной и педагогической деятельности (образовательные услуги, научные статьи, участие в экспертных советах, участие в исследованиях и др.)



А. М. Лила
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой; ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России
Россия

15522, Москва, Каширское шоссе, 34А; 125993, Москва, ул. Баррикадная, 2/1, стр. 1


Конфликт интересов:

гонорары за консультационные услуги в области научной и педагогической деятельности (образовательные услуги, научные статьи, участие в экспертных советах, участие в исследованиях и др.)



В. И. Мазуров
ФГБОУ ВО «Северо-Западный государственный медицинский университет им. И.И. Мечникова» Минздрава России
Россия

191015, Санкт-Петербург, ул. Кирочная, 41


Конфликт интересов:

гонорары за консультационные услуги в области научной и педагогической деятельности (образовательные услуги, научные статьи, участие в экспертных советах, участие в исследованиях и др.)



Е. Л. Насонов
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой; ФГАОУ ВО «Первый Московский государственный университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)
Россия

Евгений Львович Насонов

15522, Москва, Каширское шоссе, 34А; 119991 Москва, ул. Трубецкая, 8, стр. 2


Конфликт интересов:

гонорары за консультационные услуги в области научной и педагогической деятельности (образовательные услуги, научные статьи, участие в экспертных советах, участие в исследованиях и др.)



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Рецензия

Для цитирования:


Соловьев С.К., Асеева Е.А., Попкова Т.В., Лила А.М., Мазуров В.И., Насонов Е.Л. Системная красная волчанка: новые горизонты диагностики и терапии. Научно-практическая ревматология. 2020;58(1):5-14. https://doi.org/10.14412/1995-4484-2020-5-14

For citation:


Solovyev S.K., Aseeva E.A., Popkova T.V., Lila A.M., Mazurov V.I., Nasonov E.L. Systemic lupus erythematosus: new horizons for diagnosis and therapy. Rheumatology Science and Practice. 2020;58(1):5-14. (In Russ.) https://doi.org/10.14412/1995-4484-2020-5-14

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