DO NSAIDS CAUSE SPECIFIC COMPLICATIONS IN COVID-19 CORONAVIRUS INFECTION?
https://doi.org/10.14412/1995-4484-2020-340-343
Abstract
Currently, there is no clear data indicating the risk of specific complications when using non-steroidal anti-inflammatory drugs (NSAIDs), and in particular ibuprofen, for COVID-19 infection. There is also no clear clinical evidence that taking NSAIDs increases the risk of COVID-19 infection. However, when using NSAIDs in patients with acute respiratory viral diseases, keep in mind the possibility of class-specific complications from the gastrointestinal tract, cardiovascular system and kidneys. This risk is quite serious in elderly patients with multiple comorbid diseases. In addition, you should remember that taking NSAIDs and paracetamol can mask important symptoms of COVID-19 infection (in particular, fever) and lengthen the time for making a correct diagnosis.
About the Authors
A. E. Karateev
V.A. Nasonova Research Institute of Rheumatology
Russian Federation
Russian Federation
Andrey Karateev
34A, Kashirskoe Shosse, Moscow 115522
E. L. Nasonov
V.A. Nasonova Research Institute of Rheumatology; I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Russian Federation
Russian Federation
34A, Kashirskoe Shosse, Moscow 115522;
8, Trubetskaya St., Build. 2, Moscow 119991
A. M. Lila
V.A. Nasonova Research Institute of Rheumatology; Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia
Russian Federation
Russian Federation
34A, Kashirskoe Shosse, Moscow 115522;
2/1, Barrikadnaya St., Build. 1, Moscow 125993
References
1. Melville NA, Nainggolan L. Are Warnings Against NSAIDs in COVID-19 Warranted? Доступно по ссылке / Available at: https://www.medscape.com/viewarticle/926940
2. Минздрав Франции: Ибупрофен может ухудшить состояние при коронавирусе. Доступно по ссылке: https://ren.tv/news/vmire/672805-minzdrav-frantsii-ibuprofen-mozhet-ukhudshit-sostoianie-pri-koronaviruse [French Ministry of Health: Ibuprofen may worsen the condition with coronavirus. Available at: https://ren.tv/news/vmire/672805-minzdrav-frantsii-ibuprofen-mozhet-ukhudshit-sostoianie-pri-koronaviruse (In Russ.)].
3. Теслина А. ВОЗ рекомендовала не использовать ибупрофен для облегчения симптомов COVID-19. Доступно по ссылке: https://medvestnik.ru/content/news/VOZ-rekomendovala-neispolzovat-ibuprofen-dlya-oblegcheniya-simptomov-COVID- 19.html [Teslina A. WHO recommended not using ibuprofen to relieve the symptoms of COVID-19. Available at: https://medvestnik.ru/content/news/VOZ-rekomendovala-ne-ispolzovat-ibuprofen-dlyaoblegcheniya-simptomov-COVID-19.html (In Russ.)].
4. Ибупрофен или парацетамол? Ученые и врачи рассказали, что лучше принимать при COVID-19. Доступно по ссылке: https://medportal.ru/mednovosti/news/2020/03/18/055ibuprofen/ [Ibuprofen or paracetamol? Scientists and doctors have said that it is better to take with COVID-19. Available at: https://medportal.ru/mednovosti/news/2020/03/18/055ibuprofen/ (In Russ.)].
5. Доступно по ссылке: https://twitter.com/WHO/status/1240409217997189128 [Available at: https://twitter.com/WHO/status/1240409217997189128].
6. Kim SY, Chang YJ, Cho HM, et al. Non-steroidal anti-inflammatory drugs for the common cold. Cochrane Database Syst Rev. 2015 Sep 21;(9):CD006362. doi: 10.1002/14651858.CD006362.pub4
7. Pierce CA, Voss B. Efficacy and safety of ibuprofen and acetaminophen in children and adults: a meta-analysis and qualitative review. Ann Pharmacother. 2010 Mar;44(3):489-506. doi: 10.1345/aph.1M332. Epub 2010 Feb 11.
8. Wong T, Stang AS, Ganshorn H, et al. Combined and alternating paracetamol and ibuprofen therapy for febrile children. Cochrane Database Syst Rev. 2013 Oct 30;(10):CD009572. doi: 10.1002/14651858.CD009572.pub2
9. Jefferies S, Weatherall M, Young P, et al. The effect of antipyretic medications on mortality in critically ill patients with infection: a systematic review and meta-analysis. Crit Care Resusc. 2011 Jun;13(2):125-31.
10. Lee BH, Inui D, Suh GY, et al. Association of body temperature and antipyretic treatments with mortality of critically ill patients with and without sepsis: multi-centered prospective observational study. Crit Care. 2012 Feb 28;16(1):R33. doi: 10.1186/cc11211
11. Voiriot G, Philippot Q, Elabbadi A, et al. Risks Related to the Use of Non-Steroidal Anti-Inflammatory Drugs in CommunityAcquired Pneumonia in Adult and Pediatric Patients. J Clin Med. 2019 Jun 3;8(6). pii: E786. doi: 10.3390/jcm8060786
12. Lanas A, McCarthy D, Voelker M, et al. Short-term acetylsalicylic acid (aspirin) use for pain, fever, or colds – gastrointestinal adverse effects: a meta-analysis of randomized clinical trials. Drugs R D. 2011 Sep 1;11(3):277-88. doi: 10.2165/11593880-000000000-00000
13. Wen YC, Hsiao FY, Chan KA, et al. Acute Respiratory Infection and Use of Nonsteroidal Anti-Inflammatory Drugs on Risk of Acute Myocardial Infarction: A Nationwide Case-Crossover Study. J Infect Dis. 2017 Feb 15;215(4):503-9. doi: 10.1093/infdis/jiw603
14. Kellstein D, Fernandes L. Symptomatic treatment of dengue: should the NSAID contraindication be reconsidered? Postgrad Med. 2019 Mar;131(2):109-16. doi: 10.1080/00325481.2019.1561916. Epub 2019 Jan 16.
15. Fang L, Karakiulakis G, Roth M. Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? Доступно по ссылке / Available at: https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(20)30116-8/fulltext
Review
For citations:
Karateev A.E., Nasonov E.L., Lila A.M. DO NSAIDS CAUSE SPECIFIC COMPLICATIONS IN COVID-19 CORONAVIRUS INFECTION? Rheumatology Science and Practice. 2020;58(3):340-343. (In Russ.) https://doi.org/10.14412/1995-4484-2020-340-343
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