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Научно-практическая ревматология

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Проблемы боли и качества жизни при ревматоидном артрите: фокус на барицитиниб

https://doi.org/10.47360/1995-4484-2020-420-427

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Аннотация

Современная патогенетическая терапия ревматоидного артрита (РА) позволяет не только снижать активность иммунного воспаления и замедлять прогрессирование болезни, но и обеспечивать максимально быстрое устранение основных симптомов, вызывающих наибольшее беспокойство пациентов – боли, нарушения функции, утомляемости. Таким действием обладает ингибитор янус-киназ 1 и 2 – барицитиниб (БАРИ), который быстро снижает активность воспаления, обеспечивает достижение ремиссии при РА, обладает высоким анальгетический потенциалом. В обзоре обсуждается роль аутоиммунного воспаления и внутриклеточного сигнального пути JAK/STAT (Janus kinase/signal transducers and activators of transcription) в патогенезе хронической боли при РА, роль БАРИ как средства для эффективного контроля интенсивности боли и усталости. 

Об авторе

А. Е. Каратеев
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»
Россия

доктор медицинских наук, зав. лабораторией патофизиологии боли и клинического полиморфизма скелетно-мышечных заболеваний,

115522, Москва, Каширское шоссе, 34А



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Для цитирования:


Каратеев А.Е. Проблемы боли и качества жизни при ревматоидном артрите: фокус на барицитиниб. Научно-практическая ревматология. 2020;58(4):420-427. https://doi.org/10.47360/1995-4484-2020-420-427

For citation:


Karateev A.E. Problems of pain and quality of life in rheumatoid arthritis: focus on baricitinib. Rheumatology Science and Practice. 2020;58(4):420-427. (In Russ.) https://doi.org/10.47360/1995-4484-2020-420-427

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ISSN 1995-4484 (Print)
ISSN 1995-4492 (Online)