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Научно-практическая ревматология

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Перспективы применения упадацитиниба при ревматоидном артрите и других иммуновоспалительных ревматических заболеваниях

https://doi.org/10.47360/1995-4484-2020-532-543

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Аннотация

Расшифровка механизмов патогенеза ревматоидного артрита в сочетании с разработкой широкого спектра генно-инженерных биологических препаратов относятся к числу крупных достижений медицины XXI в. Новое направление фармакотерапии иммуновоспалительных ревматических заболеваний связано с созданием «таргетных» пероральных лекарственных противовоспалительных препаратов, к которым относятся ингибиторы янус-киназ. Представителем класса этих ингибиторов является упадацитиниб, который зарегистрирован для лечения ревматоидного артрита и проходит клинические испытания при анкилозирующем спондилите, псориатическом артрите и других иммуновоспалительных ревматических заболеваниях. В обзоре представлены новые данные, касающиеся эффективности и безопасности упадацитиниба при ревматоидном артрите.

Об авторах

Е. Л. Насонов
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»; ФГБОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Министерства здравоохранения Российской Федерации (Сеченовский Университет)
Россия

Насонов Евгений Львович — д.м.н., профессор, академик РАН, научный руководитель ФГБНУ «НИИР им. В.А. Насоновой»

115522, Москва, Каширское шоссе, 34а
119991, Москва, ул. Трубецкая, 8, стр. 2 



А. М. Лила
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»; ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Министерства здравоохранения Российской Федерации
Россия

Лила А.М. — д.м.н., профессор, директор ФГБНУ «НИИР им. В.А. Насоновой»

115522, Москва, Каширское шоссе, 34а
125993, Москва, ул. Баррикадная, 2/1, стр. 1 



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Для цитирования:


Насонов Е.Л., Лила А.М. Перспективы применения упадацитиниба при ревматоидном артрите и других иммуновоспалительных ревматических заболеваниях. Научно-практическая ревматология. 2020;58(5):532-543. https://doi.org/10.47360/1995-4484-2020-532-543

For citation:


Nasonov E.L., Lila A.M. The progress of rheumatology in the 21st century potential uses of upadacitinib in rheumatoid arthritis and other inflammatory rheumatic diseases. Rheumatology Science and Practice. 2020;58(5):532-543. https://doi.org/10.47360/1995-4484-2020-532-543

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ISSN 1995-4484 (Print)
ISSN 1995-4492 (Online)