Preview

Rheumatology Science and Practice

Advanced search

Treatment of aseptic necrosis of the femoral head. Clinical guidelines

https://doi.org/10.47360/1995-4484-2020-637-645

Abstract

Aseptic necrosis of bone is a serious disease that, if detected early and with adequate therapy, can be cured. Late diagnosis and lack of therapy leads to rapid joint destruction and patient disability. The proposed draft guidelines are a part of the National Clinical Guidelines for Aseptic Bone Necrosis (Osteonecrosis). Purpose of the study was creating an algorithm for diagnosing and treating osteonecrosis based on assessment of the level of evidence of literature data. The Guidelines reflect aspects of the clinical, instrumental and laboratory examination of patients with osteonecrosis, treatment options depending on the localization of the process and stage of the disease.

About the Authors

A. N. Torgashin
N.N. Priorov Central Research Institute of Traumatology and Orthopedics
Russian Federation

Alexander Torgashin

127299, Moscow, Priorova str., 10


Competing Interests: нет


S. S. Rodionova
N.N. Priorov Central Research Institute of Traumatology and Orthopedics
Russian Federation

Svetlana S. Rodionova

127299, Moscow, Priorova str., 10

Competing Interests: нет


A. A. Shumsky
N.N. Priorov Central Research Institute of Traumatology and Orthopedics
Russian Federation

Alex A. Shumsky

127299, Moscow, Priorova str., 10


Competing Interests: нет


M. A. Makarov
V.A. Nasonova Research Institute of Rheumatology
Russian Federation

Maxim A. Makarov

115522, Moscow, Kashirskoye Highway, 34A


Competing Interests: нет


A. V. Torgashina
V.A. Nasonova Research Institute of Rheumatology
Russian Federation

Anna V. Torgashina

115522, Moscow, Kashirskoye Highway, 34A


Competing Interests: нет


I. F. Akhtyamov
Kazan State Medical University
Russian Federation

Ildar F. Akhtyamov

420012, Kazan, Butlerova str., 49


Competing Interests: нет


A. N. Kovalenko
Russian Scientific Research Institute of Traumatology and Orthopedics named after R.R. Vreden
Russian Federation

Anton N. Kovalenko

195427, Saint Petersburg, Academician Baikova str., 8


Competing Interests: нет


N. V. Zagorodniy
N.N. Priorov Central Research Institute of Traumatology and Orthopedics
Russian Federation

Nikolay V. Zagorodniy

127299, Moscow, Priorova str., 10


Competing Interests: нет


S. P. Mironov
N.N. Priorov Central Research Institute of Traumatology and Orthopedics
Russian Federation

Sergey P. Mironov

127299, Moscow, Priorova str., 10


Competing Interests: нет


References

1. Malizos KN, Karantanas AH, Varitimidis SE, et al. Osteonecrosis of the femoral head: Etiology, imaging and treatment. Eur J Radiol. 2007;63:16-28. DOI: 10.1016/j.ejrad.2007.03.019

2. Ilyinykh EV, Barskova VG, Lidov PI, Nasonov EL. Osteonecrosis. Part 1. Risk factor and pathogenesis. Modern Rheumatology Journal. 2013;1:17-24 (In Russ.). DOI: 10.14412/1996-7012-2013-2362

3. Mankin HJ. Nontraumatic necrosis of bone (osteonecrosis). N Engl J Med. 1992 ;326(22):1473-1479. DOI: 10.1056/NEJM199205283262206

4. Grieser T. Atraumatische und aseptische Osteonekrose groBer Gelenke. Der Radiologe. 2019;59(7):647-662. DOI: 10.1007/s00117-019-0560-3

5. Vosmaer A, Pereira R, Koenderman JS, et al. Coagulation abnormalities in Legg-Calve-Perthes disease. Bone Joint Surg Am. 2010;92(1):121-128. DOI: 10.2106/JBJS.I.00157.

6. Calik Y, Bas E., et al. The relationship between lipid levels and bone mineral density in postmenopausal women. ECCEO. 2008:373.

7. Wu L., Gao C., Wang G., et al. Clinical study on the related markers of blood coagulation in the patients with ANFH after SARS. Front. Med. China 2007, 1(4): 410-412. DOI: 10.1007/s11684-007-0080-9

8. Varoga D, Drescher W, Pufe M, et al. Differential expression of vascular endothelial growth factor in glucocorticoid-related osteonecrosis of the femoral head. Clin Orthop Relat Res. 2009;467(12):3273-3282. DOI: 10.1007/s11999-009-1076-3.

9. Mont MA, Jones LC, Hungerford DS. Nontraumatic osteonecrosis of the femoral head: Ten years later. J Bone Joint Surg Am. 2006;88(5):1117-1132. DOI: 10.2106/JBJS.E.01041

10. Lewington M, El-Hawary R. Legg-Calvc-Perlhes disease in a patient with Albright hereditary osteodystrophy. A case report. J Bone Joint Surg Am. 2010;92(2):450-455. DOI: 10.2106/JBJS.I.00153

11. Aya-ay J, Athavale S, Morgan-Bagley S, et al. Retention, distribution, and effects of intraosseously administered ibandronate in the infarcted femoral head. J Bone Miner Res. 2007;22(1):93-100. DOI: 10.1359/jbmr.060817

12. Kim HK, Morgan-Bagley S, Kostenuik P. RANKL inhibition: A novel strategy to decrease femoral head deformity after ischemic osteonecrosis. J Bone Miner Res. 2006;21(12):1941-1954. DOI: 10.1359/jbmr.060905

13. Yang J, Wang L, Xu Y, et al. An experimental osteonecrosis offemoral head induced by a combination of a single low-dose lipopolysaccharide and methylprednisolone. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2008 ;22(3):271-275.

14. Steffen RT, Athanasou NA, Gill HS, et al. Avascular necrosis associated with fracture of the femoral neck after hip resurfacing. Histological assessment of femoral bone from retrieval specimens. Bone Joint Surg Br. 2010;92(6):787-793. DOI: 10.1302/0301-620X.92B6.23377

15. Hungerford DS, Lennox DW. The importance of increased intraosseous pressure in the development of osteonecrosis of the femoral head: implications for treatment. Orthop Clin North Am. 1985;16:635-654.

16. Ugwonali OF, Sarkissian H, Nercessian OA. Bilateral osteonecrosis of the femoral head associated with pregnancy: Four new cases and a review of the literature. Orthopedics. 2008;31(2):183. DOI: 10.3928/01477447-20080201-36

17. Yezhov IYu. Posttraumatic aseptic necrosis of the femoral head. Traumatology and Orthopedics of Russia. 1996;1:22-25 (In Russ.).

18. Cooper C, Steinbuch M, Stevenson R, et al. The epidemiology of osteonecrosis: findings from the GPRD and THIN databases in the UK. Osteoporos Int. 2010;(21):569-577. DOI: 10.1007/s00198-009-1003-1

19. Lieberman JR, Berry DJ, Mont MA, et al. Osteonecrosis of the hip: management in the 21st century. Instr Course Lect. 2003;52:337-355

20. Aldridge JM, Urbaniak JR. Avascular necrosis of the femoral head: Etiology, pathophysiology, classification, and current treatment guidelines. Am J Orthop (Belle Mead NJ). 2004;33(7):327-332.

21. Ikeuchi K, Hasegawa Y, Seki T, et al. Epidemiology of nontraumatic osteonecrosis of the femoral head in Japan. Mod Rheumatol. 2015;(25):278-281. DOI: 10.3109/14397595.2014.932038

22. Min BW, Song KS, Cho CH, et al. Untreated asymptomatic hips in patients with osteonecrosis of the femoral head. Clin Orthop Relat Res. 2008 May;466(5):1087-1092. DOI: 10.1007/s11999-008-0191-x.

23. Little CP, Ruiz AL, Harding IJ. Osteonecrosis in retrieved femoral heads after failed resurfacing arthroplasty of the hipJ Bone Joint Surg Br. 2005;87(3):320-323. DOI: 10.1302/0301-620x.87b3.15330.

24. Calder JD, Hine AL, Pearse MF, et al. The relationship between osteonecrosis of the proximal femur identified by MRI and lesions proven by histological examination. Bone Joint Surg Br. 2008;90(2):154-158. DOI: 10.1302/0301-620X.90B2.

25. Radl R, Hungerford M, Materna W, et al. Higher failure rate and stem migration of an uncemented femoral component in patients with femoral head osteonecrosis than in patients with osteoarthrosis. Acta Orthop. 2005 ;76(1):49-55. DOI: 10.1080/00016470510030319

26. Pivec R, Johnson AJ, Mont MA. Differentiation, diagnosis, and treatment of osteoarthritis, osteonecrosis, and rapidly progressive osteoarthritis. Orthopedics. 2013;36(2):118-125. DOI: 10.3928/01477447-20130122-04

27. Ficat RP. Idiopathic bone necrosis of the femoral head. Early diagnosis and treatment. J Bone Joint Surg (Br). 1985;(67):3-9.

28. Манди А, Гашпар Л. Ортопедия, травматология и протезирование. 1986;3:46-47. [Mandi A, Gashpar L. Orthopaedics, Traumatology and Prosthetics. 1986;3:46-47 (In Russ.)].

29. Gardeniers JVM. Report of the committee of staging and nomenclature. ARCO News Letter. 1993;(5):79-82.

30. Gardeniers JWM. ARCO committee on terminology and staging (report from the Nijmegen meeting). ARCO News Letter. 1991;(3):153-159.

31. Ficat RP, Arlet J. Treatment of bone ischemia and necrosis. In:Hungerford DS, Mont MA (eds.), Ischemia and Necrosis ofBone. Baltimore, USA: Williams&Wilkins; 1980:171-182.

32. Steinberg ME, Steinberg DR. Avascular necrosis of the femoral head. In: ME Steinberg (editor). The hip and its disorders. Philadelphia, PA: WB Saunders; 1991:623-647.

33. Li JD, Zhao DW, Cui DP, et al. Quantitative analysis and comparison of osteonecrosis extent of alcoholic ONFH using magnetic resonance imaging and pathology. Zhongguo Gu Yu Guan Jie Sun Shang Za Zhi, 2011;26:689-691.

34. Sautina OP, Khazov PD. MRI-diagostics of early stages of aseptic necrosis of femoral bones. I.P. Pavlov Russian Medical Biological Herald. 2008;1:50-56 (In Russ.).

35. Huang ZG, Zhang XZ, Wei HY, et al. Application of CT and MRI in volumetric measurement of necrotic lesion in patient with avascular necrosis of the femoral head. Chinese J Radiol. 2012;46:820-824.

36. Ryu KN, Jin W, Park JS. Radiography, MRI, CT, bone scan, and PET-CT. In: Koo KH, Mont M, Jones L. (eds) Osteonecrosis. Springer, Berlin, Heidelberg: 2014;179-195. DOI: 10.1007/978-3-642-35767-1_23

37. Chi Z, Wang S, Zhao D, et al. Evaluating the blood supply of the femoral head during different stages of necrosis using digital subtraction angiography. Orthopedics. 2019;42(2):e210-e215. DOI: 10.3928/01477447-20190118-01

38. Weinstein RS. Glucocorticoid-induced osteoporosis and osteonecrosis. Endocrinol Metab Clin North Am. 2012;41(3):595-611. DOI: 10.1016/j.ecl.2012.04.004

39. Mel’nichenko GA, Belaya ZE, Rozhinskaya LY, et al. Russian federal clinical guidelines on the diagnostics, treatment, and prevention of osteoporosis. Problems of Endocrinology. 2017;63(6):392-426. (In Russ.). DOI: 10.14341/probl2017636392-426

40. Tian L, Baek S-H, Jang J. Imbalanced bone turnover markers and low bone mineral density in patients with osteonecrosis of the femoral head. International Orthopaedics. 2018;42(7):1545-1549. DOI: 10.1007/s00264-018-3902-2

41. Inoue S, Igarashi M, Karube S. Vitamin D3 metabolism in idiopathic osteonecrosis of femoral head. Nihon Seikeigeka Gakkai Zasshi. 1987;61(6):659-666.

42. Klumpp R, Trevisan C. Aseptic osteonecrosis of the hip in the adult: Current evidence on conservative treatment. Clin Cases Miner Bone Metab. 2015;12(Suppl 1):39-42. DOI: 10.11138/ccmbm/2015.12.3s.039

43. Bergmann G, Graichen F, Rohlmann A. Hip joint forces during walking and running, measurement patients. J Biomechanics. 1993;(26):969-990. DOI: 10.1016/0021-9290(93)90058-m

44. Baron RX. General principles of bone biology. In: Favus MJ, ed. Primer on the metabolic bone diseases and disorders of mineral metabolism. 5th ed. Washington DC: The American Society for Bone and Mineral Research; 2003:1-8.

45. Mallen SR, Essex MN, Zhang R. Gastrointestinal tolerability of NSAIDs in elderlypatients: a pooled analysis of 21 randomized clinical trials with celecoxib andnonselective NSAIDs. Curr Med Res Opin. 2011;27(7):135966. DOI: 10.1185/03007995.2011.581274

46. Pharmacological therapy of early stages of aseptic necrosis of the femoral head: guidelines. Compiled by SP Mironov, SS Rodionova, AA Shumskiy. Moscow; 2011: 11 p. (In Russ.).

47. Rodionova SS, Kolondayev AF, Sokolov VA. Results of using Osteogenon in patients with various pathologies of the musculoskeletal system. Osteoporosis and Bone Diseases. 1999;1:43-45 (In Russ.).

48. MicIhKlsson K, Melhus H, Warensjo Lemming E, et al. Long-term calcium intake and rates of all cause and cardiovascular mortality: Community based prospective longitudinal cohort study. BMJ. 2013;346:f228. DOI: 10.1136/bmj.f228

49. Sung PH, Yang YH, Chiang HJ, et al. Cardiovascular and cerebrovascular events are associated with nontraumatic osteonecrosis of the femoral head. Clin Orthop Relat Res. 2018;476(4):865-874. DOI: 10.1007/s11999.0000000000000161

50. Maus U, Flechtenmacher J, Peters KM. Conservative treatment of atraumatic femoral head necrosis [Article in German]. Orthopade. 2018;47(9):735-744. DOI: 10.1007/s00132-018-3616-6

51. Shumskiy AA. Diagnostics and pharmacological therapy of early stages of aseptic necrosis of the femoral head: Abstract of the thesis of Cand. Sci. (Med.). Moscow; 2015:24 p. (In Russ.).

52. Ramachandran M, Ward K, Brown RR, et al. Intravenous bisphosphonate therapy for traumatic osteonecrosis of the femoral head in adolescents. J Bone Joint Surg Am. 2007;89(8):1727-1734. DOI: 10.2106/JBJS.F.00

53. Chen CH, Chang JK, Lai KA, et al. Alendronate in the prevention of collapse of the femoral head in nontraumatic osteonecrosis: A two-year multicenter, prospective, randomized, double-blind, placebo-controlled study. Arthritis Rheum. 2012;64(5):1572-1578. DOI: 10.1002/art.33498

54. Rolvien T, Schmidt T, Butscheidt S, et al. Denosumab is effective in the treatment of bone marrow oedema syndrome. Injury. 2017;48(4):874-879. DOI: 10.1016/j.injury.2017.02.020

55. Jureus J, Lindstrand A, Geijer M, et al. Treatment of spontaneous osteonecrosis of the knee (SPONK) by a bisphosphonate. Acta Orthop. 2012;83(5):511-514. DOI: 10.3109/17453674.2012.729184

56. Nakamura Y, Suzuki T, Kamimura M, et al. Alfacalcidol Increases the therapeutic efficacy of ibandronate on bone mineral density in Japanese women with primary osteoporosis. Tohoku J Exp Med. 2017;241(4):319-326. DOI: 10.1620/tjem.241.319

57. Cross M, Macara M, Little E, et al. Efficacy of zoledronate in treating osteonecrosis of femoral head: A randomized controlled trial. Osteoarthritis and Cartilage. 2018;26(Suppl 1):S309-S310. DOI: 10.1016/j.joca.2018.02.622

58. Agarwala S, Vijayvargiya M. Single dose therapy of zoledronic acid for the treatment of transient osteoporosis of hip. Ann Rehabil Med. 2019;43(3):314-320. DOI: 10.5535/arm.2019.43.3.314

59. Agarwala S, Vijayvargiya M. Bisphosphonate combination therapy for non-femoral avascular necrosis. J Orthop Surg Res. 2019;14(1):112. DOI: 10.1186/s13018-019-1152-7

60. Mironov SP, Rodionova SS, Shumskiy AA. Method for the treatment of aseptic necrosis of the femoral head. Patent of Russian Federation, N 2392942. Published July 20, 2010. Bulletin N 18. (In Russ.).

61. Shumskiy AA, Rodionova SS, Kagramanov SV. Features of the progression of aseptic necrosis of the femoral head in bilateral lesions after arthroplasty of one of the joints. N.N. Priorov Journal of Traumatology and Orthopedics. 2016;(2):35-39 (In Russ.).

62. Arai R, Takahashi D, Inoue M, et al. Efficacy of teriparatide in the treatment of nontraumatic osteonecrosis of the femoral head: a retrospective comparative study with alendronate. BMC Muscu-loskelet Disord. 2017;18(1):24. DOI: 10.1186/s12891-016-1379-y

63. ClaBen T, Becker A, Landgraeber S, et al. Long-term clinical results after iloprost treatment for bone marrow edema and avascular necrosis. Orthop Rev (Pavia). 2016;8(1):6150. DOI: 10.4081/or.2016.

64. Glueck CJ, Freiberg RA, Sieve L, et al. Enoxaparin prevents progression of stages I and II osteonecrosis of the hip. Clin Orthop Relat Res. 2005;435:164-170. DOI: 10.1097/01.blo.0000157539.67567.03

65. Bruyere O, Honvo G, Veronese N, et al. An updated algorithm recommendation for the management of knee osteoarthritis from the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO. Semin Arthritis Rheum. 2019;49(3):337-350. DOI: 10.1016/j.semarthrit.2019.04.008.

66. Mauro GL, Scaturro D, Sanfilippo A, et al. Intra-articular hyaluronic acid injections for hip osteoarthritis J Biol Regul Homeost Agents. 2018;32(5):1303-1309.

67. Aggarwal A, Poornalingam K, Marwaha N, et al. Good functional outcome with use of platelet-rich plasma in osteonecrosis of femoral head. Orthopaedic Proceedings. 2018;100-B(SUPP_5):19.

68. Kompel AJ, Roemer FW, Murakami AM, et al. Intra-articular corticosteroid injections in the hip and knee: Perhaps not as safe as we thought? Radiology. 2019;293(3):656-663. DOI: 10.1148/radi-ol.2019190341.

69. Trancik T, Lunceford E, Strum D. The effect of electrical stimulation on osteonecrosis of the femoral head. Clin Orthop Relat Res. 1990;256:120-124.

70. Reis ND, Schwartz O, Militianu D, et al. Hyperbaric oxygen therapy as a treatment for stage-I avascular necrosis of the femoral head. J Bone Joint Surg Br. 2003;85(3):371-375. DOI: 10.1302/0301-620x.85b3.13237.

71. Sconza C, Respizzi S, Virelli L, et al. Oxygen-ozone therapy for the treatment of knee osteoarthritis: a systematic review of randomized controlled trials. Arthroscopy. 2020;36(1):277-286. DOI: 10.1016/j.arthro.2019.05.043

72. Iliakis E, Bonetti M, Iliakis A. Osteonecrosis of the femoral head: Could oxygen- ozone therapy became a treatment option? J Ozone Therapy. 2015;1(1):1-7.

73. Kong FR, Liang YJ, Qin SG, et al. Clinical application of extracorporeal shock wave to repair and reconstruct osseous tissue framework in the treatment of avascular necrosis of the femoral head (ANFH). Zhongguo Gu Shang. 2010;23(1):12-15.

74. Akhtiamov IF, Anisimov OG, Budyak YV. A new treatment for early forms of aseptic necrosis of the femoral head (preliminary report). N.N. Priorov Journal of Traumatology and Orthopedics. 2011;(1):33-37 (In Russ.).

75. Akhtyamov IF, Kovalenko AN, Anisimov OG, et al. Treatment of osteonecrosis of the femoral head. Kazan: Skripta; 2012:176 p. (In Russ.).

76. Rajagopal M, Samora JB, Ellis TJ. Efficacy of core decompression as treatment for osteonecrosis of the hip: a systematic review. Hip Int. 2012;22(5):489-493. DOI: 10.5301/HIP.2012.9748

77. Hua К, Yang Y, Feng J, et al. The efficacy and safety of core decompression for the treatment of femoral head necrosis: a systematic review and meta-analysis. J Orthop Surg Res. 2019;14(1):306. DOI: 10.1186/s13018-019-1359-7.

78. Li R, Lin Q, Liang X, et al. Stem cell therapy for treating osteonecrosis of the femoral head: From clinical applications to related basic research. Stem Cell Res Ther. 2018;9(1):291. DOI: 10.1186/s13287-018-1018-7.

79. Calori GM, Mazza E, Colombo A, et al. Core decompression and biotechnologies in the treatment of avascular necrosis of the femoral head. EFORT Open Rev. 2017;2(2):41-50. DOI: 10.1302/2058-5241.2.150006

80. Hernigou P, Beaujean F. Treatment of osteonecrosis with autologous bone marrow grafting. Clin Orthop Relat Res. 2002;(405):14-23. DOI: 10.1097/00003086-200212000-00003.

81. Ito H, Tanino H, Yamanaka Y, et al. Long-term results of conventional varus half-wedge proximal femoral osteotomy for the treatment of osteonecrosis of the femoral head. J Bone Joint Surg Br. 2012;(94):308-314. DOI: 10.1302/0301-620X.94B3.27814

82. Ali SA, Christy JM, Griesser MJ, et al. Treatment of avascular necrosis of the femoral head utilising free vascularised fibular graft: a systematic review. Hip Int. 2014;24(1):5-13. DOI: 10.5301/hipint.5000076

83. Yuan B, Taunton MJ, Trousdale RT. Total hip arthroplasty for alcoholic osteonecrosis of the femoral head. Orthopedics. 2009;32(6):400. DOI: 10.3928/01477447-20090511-06

84. Kim YH, Oh SH, Kim JS, et al. Contemporary total hip arthroplasty with and without cement in patients with osteonecrosis of the femoral head. J Bone Joint Surg Am. 2003;85(4):675-681. DOI: 10.2106/00004623-200304000-00014.

85. Cuckler JM, Moore KD, Estrada L. Outcome of hemiresurfacing in osteonecrosis of the femoral head. Clin Orthop Relat Res. 2004;(429):146-150. DOI: 10.1097/01.blo.0000150121.88033.


Review

For citations:


Torgashin A.N., Rodionova S.S., Shumsky A.A., Makarov M.A., Torgashina A.V., Akhtyamov I.F., Kovalenko A.N., Zagorodniy N.V., Mironov S.P. Treatment of aseptic necrosis of the femoral head. Clinical guidelines. Rheumatology Science and Practice. 2020;58(6):637-645. (In Russ.) https://doi.org/10.47360/1995-4484-2020-637-645

Views: 20243


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 1995-4484 (Print)
ISSN 1995-4492 (Online)