Microscopic polyangiitis: Modern concepts and treatment options
I. T. Murkamilov,
K. A. Aitbaev,
V. V. Fomin,
I. O. Kudaibergenova,
F. A. Yusupov,
Zh. A. Murkamilova,
T. V. Beketova https://doi.org/10.47360/1995-4484-2021-608-614
Abstract
The article summarizes the modern concepts of microscopic polyangiitis (MPA), a primary ANCA-associated systemic necrotizing vasculitis without immune globulin deposition (pauci-immune) that affects mainly small vessels, while granulomatous inflammation is absent. Necrotizing glomerulonephritis is very common and pulmonary capillaritis often occurs. MPA can cause rapidly progressive damage to organ systems. The modern possibilities of MPA treatment, primarily anti-B cell therapy with rituximab, are discussed.
About the Authors
I. T. Murkamilov
I.K. Akhunbaev Kyrgyz State Medical Academy
Kyrgyzstan
Kyrgyzstan
720020, Kyrgyzstan, Bishkek, Akhunbaev str., 92
K. A. Aitbaev
Scientific and Research Institute of Molecular Biology and Medicine
Kyrgyzstan
Kyrgyzstan
720040, Kyrgyzstan, Bishkek, Togolok Moldo str., 3
V. V. Fomin
I.M. Sechenov First Moscow State Medical University of the Ministry of Health Care of Russian Federation (Sechenov University)
Russian Federation
Russian Federation
119991, Russian Federation, Moscow, Trubetskaya str., 8, building 2
I. O. Kudaibergenova
I.K. Akhunbaev Kyrgyz State Medical Academy
Kyrgyzstan
Kyrgyzstan
720020, Kyrgyzstan, Bishkek, Akhunbaev str., 92
F. A. Yusupov
Osh State University
Kyrgyzstan
Kyrgyzstan
723500, Kyrgyzstan, Osh, Lenin str. 331
Zh. A. Murkamilova
B.N. Yeltsin Kyrgyz-Russian Slavic University
Kyrgyzstan
Kyrgyzstan
720000, Kyrgyzstan, Bishkek, Kiev str. 44
T. V. Beketova
V.A. Nasonova Research Institute of Rheumatology
Russian Federation
Russian Federation
115522, Russian Federation, Moscow, Kashirskoye Highway, 34A
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Murkamilov I.T., Aitbaev K.A., Fomin V.V., Kudaibergenova I.O., Yusupov F.A., Murkamilova Zh.A., Beketova T.V. Microscopic polyangiitis: Modern concepts and treatment options. Rheumatology Science and Practice. 2021;59(5):608-614. (In Russ.) https://doi.org/10.47360/1995-4484-2021-608-614
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