Actovegin administration in patients with ulcerated gout tophuses
https://doi.org/10.14412/1995-4484-2005-39
Abstract
Objective. To study actovegin efficacy in the treatment of chronic skin ulcers due to ulceration of tophuses in pts with chronic tophaceous gout. Materials and methods. 6 pts with chronic tophaceous gout aged 52 to 77 years with disease duration from 6 to 20 years with longstanding persisting skin ulcers due to tophuses ulceration were included. In addition to allopuri- nol, steroid and nonsteroidal anti-inflammatory drugs they were treated with actovegin 20% intravenously and local applications of 2% actovegin gel. Clinical examination was performed before and after the course of therapy- Results. Two from six pts showed healing of single chronic ulcers to the end of the treatment course. In the remaining pts ulcer count and size decrease was achieved. Conclusion. Actovegin administration in combined therapy of chronic skin ulcers in pts with chronic tophaceous gout promoted healing of the defects in all cases.
References
1. <div><p>Насонова В.А., Барскова В.Г. Ранние диагностика и лечение подагры - научно обоснованное требование улучшения трудового и жизненного прогноза больных. Научно-практич. ревматол., 2004, 1, 5-7</p><p>Wallace S.L., Robinson Н., Masi А.Т. et al. Preliminary criteria for the classification of the acute arthritis of gout. Arthr. Rheum., 1977, 20, 895-900</p><p>Hench P.S. The diagnosis of gout and gouty arthritis. J. Lab. Clin. Med., 1936,220, 48-55</p><p>Gutman A.B. The past four decades of progress in the knowledge of gout, with an assessment of the present status. Arthr. Rheum., 1973, 16,431-445</p><p>Пихлак Э.Г Подагра. М., "Медицина", 1970</p><p>Gutman А.В. Gout, in Beeson PB, McDermott W (eds): Textbook of Medicine (ed 12). Philadelphia, Saunders, 1967, 1238</p><p>Obermaier-Kusser B., Muhlbacher C., Mushack J. et al. Further evidence for a two-step model of glucose-transport regulation. Inositol phosphate-oligosaccharides regulate glucose-carrier activity. Biochem. J., 1989, 3, 699-705</p><p>Серегин Г.И., Ленькова H.A., Рытвинский C.C., Коганова Н.А Актовегин в комплексной терапии больных с обширными раневыми повреждениями. Актовегин. Новые аспекты клинического применения. Сб. научно-практич. статей. М., 2002. 187-192</p><p>Monnard P. Konservative Behandlung von Lochgeschwuren und diabetischer Gangran mit einem eiwei?freien Kalbsblutextrakt Praxis, Schweiz. Rundschau f. Med., 63, 1974, 909</p><p>Tsang M.W., Wfang W.K., Hung C.S. et al. Human epidermal growth factor enhances healing of diabetic fool ulcers. Diabetic Care, 2003, 26(6), 1856-1861 И. Новицкий B.A, Смолянннов А.Б., Гаврюшин O.A., Мовчан K.H. Коррекция расстройств при лечении больных с длительно рубцующимися гастродуоденальными язвами препаратом Актовегин. Проблемы излечимости в гастроэнтерологии. Решенные и нерешенные клинические загадки: Тр. 25-ой конф. Смоленск, 1997, 392-397</p><p>Kusztos D., Bereczky М., Ablonczy D. et al. A controlled trial comparing two drugs used to treat peripheral vascular disorders with trophic Lesions. VASA, 1, 1972, 212</p><p>Pfister A., Koller W. Treatment of fresh muscle injury. Sportverletz Sportschaden, 1990, 4(1), 41-44</p><p>McLauchlan GJ, Handoll HH. Interventions for treating acute and chronic Achilles tendinitis. Cochrane Database Syst. Rev., 2001, 2. CD000232 [MEDLINE]</p><p>Павлов В.П., Асин Б.А., Макаров C.A., Матушевский ГА. Хирургическое лечение хронической подагры. Научно- практич. ревматол., 2000, 3, 54-56</p><p>Linton R.R., Talbott J.H. Surgical ireatment of tophaceous gout. Ann. Surg., 1943, 117, 161-182</p><p>Larmon W.A. Surgical management of tophaceous gout. Clin. Orthop., 1970,71,56-69</p><p>Groff G.D., Franck W.A., Raddatz D.A. Systemic steroid therapy for acute gout: a clinical trial and review of the literature. Semin. Arthr. Rheum., 1990, 19(6), 329-336</p><p>Насонов ЕЛ., Чичасова H.B., Ковалев Ю.В. Глюкокортико- иды в ревматологии. М., "Медицина”, 1998</p></div><br />
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For citations:
Eliseev M.S., Barskova V.G. Actovegin administration in patients with ulcerated gout tophuses. Rheumatology Science and Practice. 2005;43(5):35-39. (In Russ.) https://doi.org/10.14412/1995-4484-2005-39
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