Lupus nephritis – modern aspects of diagnosis and therapy. Part I
https://doi.org/10.47360/1995-4484-2024-55-64
Abstract
Lupus nephritis (LN) is considered to be one of the most frequent severe manifestations of systemic lupus erythematosus (SLE), its various colonic manifestations occur in at least 50% of SLE patients, both at the onset and at various stages of the disease, and develop LN is considered one of the most important predictors of mortality in SLE. The structure of nephritis is dominated by diffuse proliferative LN with clinical and morphological signs of progression and the rapid development of terminal renal failure. SLE is diagnosed based on the 2019 EULAR/ACR (European Alliance of Associations for Rheumatology/American College of Rheumatology) diagnostic classification criteria. To confirm the diagnosis, evaluate the prognosis, and choose the tactics of treating the dis-ease, all patients in the absence of contraindications require a kidney biopsy. In addition to LN, the spectrum of SLE-associated renal lesions includes vascular pathology represented by thrombotic microangiopathy, lupus vasculopathy or vasculitis, tubulointerstitial injury, and lupus podocytopathy.
About the Authors
S. K. Solovyev
V.A. Nasonova Research Institute of Rheumatology
Russian Federation
Russian Federation
Sergey K. Solovyev
115522, Moscow, Kashirskoye Highway, 34A
N. L. Kozlovskaya
A.I. Yevdokimov Moscow State University of Medicine and Dentistry
Russian Federation
Russian Federation
Natalia L. Kozlovskaya
127473, Moscow, Delegatskaya str., 20, building 1
E. A. Aseeva
V.A. Nasonova Research Institute of Rheumatology
Russian Federation
Russian Federation
Elena A. Aseeva
115522, Moscow, Kashirskoye Highway, 34A
A. A. Baranov
Yaroslavl State Medical University
Russian Federation
Russian Federation
Andrey A. Baranov
150000, Yaroslavl, Revolyutsionnaya str., 5
N. Yu. Nikishina
V.A. Nasonova Research Institute of Rheumatology
Russian Federation
Russian Federation
Nina Yu. Nikishina
115522, Moscow, Kashirskoye Highway, 34A
E. L. Nasonov
V.A. Nasonova Research Institute of Rheumatology;
I.M. Sechenov First Moscow State Medical University of the Ministry of Health Care of Russian Federation (Sechenov University)
Russian Federation
Russian Federation
Evgeny L. Nasonov
115522, Moscow, Kashirskoye Highway, 34A;
119991, Moscow, Trubetskaya str., 8, building 2
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For citations:
Solovyev S.K., Kozlovskaya N.L., Aseeva E.A., Baranov A.A., Nikishina N.Yu., Nasonov E.L. Lupus nephritis – modern aspects of diagnosis and therapy. Part I. Rheumatology Science and Practice. 2024;62(1):55-64. (In Russ.) https://doi.org/10.47360/1995-4484-2024-55-64
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