Aortic involvement in a patient with relapsing polychondritis. Clinical observation
https://doi.org/10.47360/1995-4484-2026-202-207
Abstract
Relapsing polychondritis (RP) is a systemic autoimmune disease characterized by inflammation and destruction of cartilage in various organs. Aortic involvement in RP is relatively rare, occurring in 6.7–9.7% of cases, and is associated with a high risk of mortality (27.3–41.3%) and surgical interventions (65%). Typically, cardiac and aortic involvement in patients with RP is identified approximately five years after the onset of the first symptoms, with 19% of cases being asymptomatic. There are currently no universally accepted standards for screening, diagnosis, and treatment of aortic involvement in RP.
We present a clinical case of a patient with RP, aortic involvement, and the development of an aneurysm, who underwent sequential therapy with cyclophosphamide and rituximab. This treatment approach allowed for the control of disease activity and a reduction in glucocorticoid dosage.
About the Authors
D. A. Dibrov
V.A. Nasonova Research Institute of Rheumatology
Russian Federation
Competing Interests:
Russian Federation
Danil A. Dibrov
115522, Moscow, Kashirskoye Highway, 34A
Competing Interests:
none
T. M. Reshetnyak
V.A. Nasonova Research Institute of Rheumatology; Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of the Russian Federation
Russian Federation
Competing Interests:
Russian Federation
Tatiana M. Reshetnyak
115522, Moscow, Kashirskoye Highway, 34A; 125993, Moscow, Barrikadnaya str., 2/1, building 1
Competing Interests:
none
N. V. Demidova
V.A. Nasonova Research Institute of Rheumatology
Russian Federation
Competing Interests:
Russian Federation
Natalia V. Demidova
115522, Moscow, Kashirskoye Highway, 34A
Competing Interests:
none
A. V. Alekseeva
V.A. Nasonova Research Institute of Rheumatology
Russian Federation
Competing Interests:
Russian Federation
Anna V. Alekseeva
115522, Moscow, Kashirskoye Highway, 34A
Competing Interests:
none
L. M. Blank
V.A. Nasonova Research Institute of Rheumatology
Russian Federation
Competing Interests:
Russian Federation
Leonid M. Blank
115522, Moscow, Kashirskoye Highway, 34A
Competing Interests:
none
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Review
For citations:
Dibrov D.A., Reshetnyak T.M., Demidova N.V., Alekseeva A.V., Blank L.M. Aortic involvement in a patient with relapsing polychondritis. Clinical observation. Rheumatology Science and Practice. 2026;64(2):202-207. (In Russ.) https://doi.org/10.47360/1995-4484-2026-202-207
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