Научно-практическая ревматология

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Skin thicking simulating scleroderma is not rare in diabetes mellitus (about 2% among patients with diabetes mellitus), however it is not well known to rheumatologists and endocrinologists. The basis of the syndrome are the abnormalities of collagen and glycosaminoglycans metabolism accompanying by the acid mucopolysaccharides accumulation in the deep part of the reticular dermis. Three cases of pseudosclerodrma in patients with long-standing complicated insulin-dependent diabetes mellitus are presented. The main clinical manifestations of pseudoscleroderma were marked cutaneous induration of the neck, body and proximal parts of extremities liked that of scleredema of Buschke ( 2 patients), and primary paraarticular induration leaded to the flexion contractures liked that of paraneoplastic scleroderma ( I patient). Possible mechanisms of development, clinical and morphological peculiarities and treatment for this syndrome are discussed.

Список литературы

1. <div><p>Гусева Н.Г. Системная склеродермия и псевдосклеродер мические синдромы. М., “Медицина'’. 1993.</p><p>Гусева Н.Г. Системная склеродермия и склеродермичес- кая группа болезней. Русск. мед. журнал, 2000, 10, 383387.</p><p>Руководство по клинической эндокринологии (под редакцией проф. Н.Т. Старковой). Стаикт-Питербург, "Питер- Пресс”, 1996. 213.</p><p>Cohn R.P. Wheeler С.Е., Briggaman R.A., Hill Ch. “Scleredema adultorum оГ Buschke and diabetes meilitus”. Arch. Derm., 1970, 101, 27-35.</p><p>Eaton R.P, “The collagen hydration hypothesis: a new paradigm for the secondary complications of diabetes mellitus”. J. Chron. Dis. 1986, 39 (10), 763-766.</p><p>Eaton R.P., Sibbitt W.L., Harsh A. “The effect of an aldose reductase inhibiting agent on limited joint mobility in diabetic patients”. JAMA, 1985, 253 (10), 1437-1441.</p><p>Hanna W„ Friesen D., Bombardier C. et al. “Pathologic features of diabetes thick skin". J. Am. Acad. Dermatol., 1987, 16 (3), 546-553.</p><p>Jelinek J.E. “The skin in diabetes". Diabetic medicinc, 1993, 10, 201-213.</p><p>Krakowski A., Covo J. Berlin C. “Diabetic scleroderma". Dermatol., 1973, 143, I93-I9S.</p><p>Kunzelmann V. Schnelle C. Audring H. et al. "Scleroedema diabeticorum”. Hautarzt, 1996, 47* 214-217.</p><p>Monk B.E., Pembroke A.C., Vollum D.I. “Scleredema of Buschke and diabetes mellitus: a report of two cases”. Clin. Exp. Dermatol., 1983, 8, 389-391.</p><p>Roupe G., Laurent T.C., Malmstrom A., Suurkula M.t Sarnstrand B. “Biochemical characterization and tissue distribution of the scleredema in a case of Buschke's disease”. Acta Derm. Venereol. (Stockh), 1987, 67, 193-198,</p><p>Venencie P.Y., Powell F.C. Daniel Su W.P., Perry H.O. "Scleroderma: a review of thirty-three cases”. J. Am. Acad, of Dermatol., 1984, II (I), 128-134.</p></div><br />

Для цитирования:

Невская Т.А., Gouseva N.G. ПСЕВДОСКЛЕРОДЕРМИЧЕСКИЙ СИНДРОМ ПРИ САХАРНОМ ДИАБЕТЕ. Научно-практическая ревматология. 2001;39(5):79-84.

For citation:

Nevskaya T.A., Gouseva N.G. PSEUDOSCLERODERMAL SYNDROME IN DIABETES MELLITUS. Rheumatology Science and Practice. 2001;39(5):79-84. (In Russ.)

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ISSN 1995-4484 (Print)
ISSN 1995-4492 (Online)