Risk factors for gout: Gender differences
https://doi.org/10.14412/1995-4484-2011-516
Abstract
Objective: to comparatively assess risk factors for gout in male and female patients with this condition. Subjects and methods. The study enrolled 340 gouty patients (289 men and 51 women) examined in the period 2002 to 2009. The diagno sis corresponded to the criteria developed by S.L. Wallace. The mean age was 52.3±11.4 years for the women and 52.3±10.4 years for the men. The study group included female patients with gout and a comparison group comprised male patients with this condition. All the patients were interviewed using a questionnaire to identify risk factors for gout: the regular use of diuretics or alcoholic beverages before the onset of this disease, the presence of arterial hypertension (AH), and menopause in women. Results. The intake of diuretics before gout was reported by 57% of the women and 19.7% of the men (p < 0.00001). The drugs were given to all the men according to medical indications; 10 of 29 women took diuretics to lose weight. Alcohol was consumed more than twice week ly by 17.6% of the women and 33.6% of the men (p = 0.032). The median weekly alcohol consumption was 2 (range 1-4) conventional units (CU) in the women and 4 (range 2-10) CU in the men (p = 0.002). AH occurring the onset of gout was found in 30 (59%) women and 136 (47%) men (p = 0.13). Menopause developing prior to the onset of gout was noted in 26 (51%) women. Conclusion. Among possible causes of gout, the use of diuretics is more common in the women than in the men, moreover, the former take them unfairly in one third of cases. The women consume alcohol less frequently and in smaller quantities, but the rate of female intake of alcoholic beverages is associated with younger age at the onset of gout. In early menopause or amenorrhea, gout more frequently occurs at a young age. AH is a common risk factor for gout in both the women (59%) and the men (47%).
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Eliseyev M.S., Chikalenkova N.A., Denisov I.S., Barskova B.G. Risk factors for gout: Gender differences. Rheumatology Science and Practice. 2011;49(6):28-31. (In Russ.) https://doi.org/10.14412/1995-4484-2011-516
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