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Parvovirus B19 infections serological diagnostics in rheumatic diseases

https://doi.org/10.14412/1995-4484-2005-612

Abstract

Objective. To study contamination with parvovirus B19 of a group of patients with rheumatic diseases (RD). Methods. 77 pts with RD (mean age 42,5 years, 79% female) admitted to Institute of Rheumatology of RAMS were examined. 34 of them had rheumatoid arthritis (RA), 11 - systemic lupus erythematosus (SLE) and Sjogren's disease (SD), 15 with osteoarthritis (OA) and seronegative spondyloarthritides (SS) and 17 with early (before a year) undifferentiated arthritis (EUA). Quantitative determination of IgM and IgG serum antibodies to parvovirus BI9 was performed by I FA with IBL kits (Hamburg, Germany). Results. Anti-B19 IgG antibodies were found in 52% of pts, IgM antibodies - only in one case. Mean antibodies values in pts with RD of disease duration less then 6 months were significantly higher then in pts with longer disease duration (21,5+36 U/ml and 8,4+14.7 U/ml respectively, p<0,05). Anti-B 19 antibodies were present in 62% of pts with RA, 53% of pts with EUA, 45% of pts with SD, 33% of pts with OA and SS. High levels of antibodies (4-10 times higher positivity threshold) were revealed in 13 pts with different RD with short duration of joint syndrome (6,3±7,6 months) and fever at presentation. A case of B19 parvovirus infection in a boy of 3 years age accompanied by symptoms of Still's disease is described.

References

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Review

For citations:


Ananjeva L.P., Koneva O.A., Soldatova S.I., Salugina S.O., Urumova M.M., Karateev D.E., Egorova O.N., Panasuk E.Yu., Bunchuk N.V. Parvovirus B19 infections serological diagnostics in rheumatic diseases. Rheumatology Science and Practice. 2005;43(4):18-23. (In Russ.) https://doi.org/10.14412/1995-4484-2005-612

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ISSN 1995-4484 (Print)
ISSN 1995-4492 (Online)