Long term anticoagulant therapy with varfarin efficacy and safety in patients with venous thrombosis

Abstract

Objective. To assess efficacy and safety of a year and three-year therapy with varfarin in pts experienced one or several episodes of venous thrombosis. Material and methods. 220 pts with one or more episodes of venous thrombosis (VT) were included. 141 pts received varfarin during a year, 79-3 years.Mean age of pts with the first thrombosis was 41,6+6,3 years, with rethrombosis - 47,4+9,5 years. Exclusion criteria were contraindications to varfarin administration, severe trauma and vast operations within 1 month before the development of VT, tumors renal ang hepatic function disturbances. Results. During the follow up thrombosis did not recur. Frequency of hemorrhagic complications during the first year was about 20%. 2/3 of bleeding episodes occurred within the first 6 months of treatment during titration of effective therapeutic dose of varfarin. Later frequency of hemorrhagic complications decreased to 6,4% within the 2nd year and 3,8% within the 3rd year. Conclusion. In most cases it is impossible to determine the cause of bleeding at normal level of INO and the cause ol'INO elevation immediatelly before the appearance of hemorrhagic complications