Relationship of endothelial dysfunction and kidney functional state in patients with systemic sclerosis
https://doi.org/10.14412/1995-4484-2009-670
Abstract
Objective. To study vasoregulatory function of vascular wall in pts with systemic sclerosis (SS) and chronic scleroderma-related renal disease (SRD) and determine relationship with main measures of kidney functional state. Material and methods. 25 pts with SS (24 female) with mean age 46,4±10,7 years and mean disease duration 7,5±4,7 years were included. 24 pts (96%) had diffuse form and 17 pts (68%) – generalized stage of SS. 22 pts (88%) had chronic course of the disease with typical damage of vessels, heart, lungs and skin. SRD was revealed in 17 pts (68%). Sonographic method of Celermejer D. et al. (1992) was used for assessment of vascular endothelial function. 15 healthy persons without SS were included in control group. Results. Most prominent changes of brachial artery reactivity with insufficient vasodilatation and paradoxical vasoconstriction to reactive hyperemia were revealed in most pts with moderate and severe SRD. Conclusion. These changes of endothelium dependent and endothelium independent parameters in pts with SRD pointed to irreversible probably scleroderma-related vascular wall damage.
References
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For citations:
Basova A.M., Bugrova O.V., Morosova E.V. Relationship of endothelial dysfunction and kidney functional state in patients with systemic sclerosis. Rheumatology Science and Practice. 2009;47(6):20-25. (In Russ.) https://doi.org/10.14412/1995-4484-2009-670
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