FUNCTIONAL ACTIVITY OF COMPLEMENT CLASSIC WAY ACTIVATION COMPONENTS AND ART1CULAS DAMAGE IN RHEUMATOID ARTRITIS

Abstract

A relationship between X - ray joints changes and functional activity of classical pathway complement components in R4 was investigated. 31 patients with the moderate activity ofRA (ARA 1987) have been examined. Disease duration was 4,5lyear±3,84 (SD). X-ray stage was estimated by Steinbrocker (I-II-III-IV). II patients were in II stage, 8 in III stage, 12 in IV-stage. Concentration of C3 and C4 components have been evaluated by radial immunodiffuision, functional activity of complement components (Clq. C1-C5) - using a microhemolilical systems. High correlation values between functional activity C1-C4 complement components and X-ray stage of disease were obtained (Spearman correlation: 0,38<R<0,7 [10 5<p<0,03]). Thereby high FA of classical pathway complement components is associated with severe joints destruction. Correlation ofC3, C4 concentration was not significant. This fact can be resulting from the phenomenon that complement classical pathway take part in joints destruction in RA. The feature of relationship can be ascribed to both primary high FA of complement classical pathway in patients with se\'ere joints destruction and local consumption of complement at early stage ofjoints destruction.