Variants of intensification of immunosuppressive therapy of rheumatoid arthritis
https://doi.org/10.14412/1995-4484-2007-835
Abstract
Objective. To assess influence of different treatment intensification regimens on clinico- laboratory parameters of activity and quality of life of pts with rheumatoid arthritis (RA). Material and methods. 40 RA pts of group 1 received pulse-therapy with methotrexate (MT) and dexamethasone (DM), 20ptsofgroup 2 received pulse-therapy with methylprednisolone (MP) and cyclophosphane (CP). After that all pts continued treatment with disease modifying antirheumatic drugs. Pts were examined at baseline, 1 and 6 months after completion of therapy intensification cycle. Results. At 1 month tender and swollen joint counts decrease in group 1 was more prominent than in group 2. After 6 months significant decrease of all disease activity measures was maintained in group 1 but not in pts received CP and MP. Conclusion. Pulse therapy with MT and DM provided more prolonged decrease of RA clinico-laboratory activity than treatment with MP and CP. Group 1 pts also showed significant increase of quality of life. None method of intensive treatment caused severe adverse events.
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Review
For citations:
Vasiljeva E.A., Maslyansky A.L., Ilivanova E.P., Grigorjeva A.L., Trishin V.M., Masurov V.I. Variants of intensification of immunosuppressive therapy of rheumatoid arthritis. Rheumatology Science and Practice. 2007;45(2):30-35. (In Russ.) https://doi.org/10.14412/1995-4484-2007-835
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