DNA-abzymes in autoimmune diseases in clinic and experiment
https://doi.org/10.14412/1995-4484-2003-1125
Abstract
DNA-abzymes enzymes in autoimmune diseases in clinic and experiment T.E. Naumova, O.M. Durova, A.G. Gabibov, Z.S. Alekberova, S. V. Suchkov DNA-hydrolyzing autoantibodies (AAB) or DNA-abzymes can be found in autoimmune diseases in clinic and experiment. Technology of serum express screening for presence of DNA abzymes is described. Comparative study of DNA-hydrolising activity in patients with different forms of systemic and organ-specific autoimmune diseases was performed. Blood of clinically healthy donors was usually free of IgG DNA-abzymes. DNA-abzymes were most often revealed in patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) less often in patients with organ-specific forms of autoimmune disturbances. The results of the study confirm the hypothesis of autoimmune origin of IgG DNA abzymes and demonstrate the possibility to use them in clinical practice for monitoring to disease activity in SLE and RA.
References
1. <div><p>Кит Ю.А., Семенов Д.В., Невинский Г.А. Существуют ли каталитически активные антитела у здоровых людей? Мол. биол., 1995, 29, 4, 893-906.</p><p>Невинский Г.А., Канышкова Т.Г., Бунева В.Н. Природные каталитически активные антитела (абзимы) в норме и при патологии. Биохимия, 2000, 65, 11, 1473-1487.</p><p>Насонова В.А. Системная красная волчанка. М. Медицина. 1982.</p><p>Пономаренко Н.А., Александрова Е.С., Воробьев И.И. и др. Каталитическая активность нативных антител у мышей с аутоиммунными нарушениями. ДАН, 2000, 375(2), 256-259.</p><p>Сучков С. В. Сравнительное исследование каталитических (ДНК-гидролизующих) и цитотоксических свойств анти-ДНК аутоантител. БЭБМ, 2001, 131, 4, 420-423.</p><p>Сучков С.В., Габибов А.Г. Аутоантитела различных уровней специфичности и их клиническое значение при системных и локализованных формах аутоиммунной патологии. Аллергол. и иммунол., 2001, 2(1), 137-147.</p><p>Bencovich SJ. Catalytic antibodies. Ann. Rev. Biochem., 1992, 61, 29-54.</p><p>Bruns A., Blass S., Hausdorf G. et al. Do elevated levels of serum-soluble Fas contribute to the persistence of activated lymphocytes of SLE. Arthr. Reum., 2000, 43(10), 23072315.</p><p>Casiano C.A., Tan E.M. Resent development in the understanding of antinuclear antibodies. Int. Arch. Allerg. Immunol., 1996, 111 (4), 308-313.</p><p>Chan T.M., Cheng I.K. Identification of endothelial cell membrane proteins that bind anti-DNA antibodies from patients with SLE by direct and indirect mechanisms. J. Autoimmun., 1997, 10(5), 433-439.</p><p>Edworthy S., Bloch D. The American Rheumatism Assotiation 1987. Revised criteria for classification of rheumatoid arthritis. J. Rheum., 1988, 31, 315- 324.</p><p>Gabibov A.G. DNA- hydrolyzing antibodies. Appl. Biochem. Biotechnol., 1994,47, 293-302.</p><p>Kozyr A.V. Antibodies to nuclear antigens. Appl. Biochem., 2000, 83, 255-270.</p><p>Kozyr A.V., Kolesnikov A.V., Aleksandrova E.S. et al. Novel functional activities of anti-DNA autoantibodies from sera of patienties with lymphoproliferative and autoimmune diseases. Appl. Biochem. Biotechnol., 1998,75, 45-61.</p><p>Lemer R.A., Janda K.D. Catalytic antibodies of protein function in real time. EXS, 1995, 73, 121-138.</p><p>Lemer R.A. Catalytic antibodies: the concept and the promise. Hosp, Pract. ( Off. Ed.), 1993, 28(7), 53-59.</p><p>Lemer R.A., Bencovich S.J., Shultz P.G. At the crossroads of chemistry and immunology: catalytic antibodies. Science, 1991, 252(5006), 659-667.</p><p>Monestier M. Antibodies to nucleosomes and histone DNA complex. Methods, 1997, 4(1), 36-43.</p><p>Paul S. Natural catalytic antibodies. Mol. Biotechnol., 1996, 5(3), 197-207.</p><p>Paul S. Mechanism and functional role of antibody catalysis. Appl. Biochem. Biotechnol., 1998, 75(1), 13-24.</p><p>Preliminary criteria for classification of sclerodermia. Arthr. Rheum., 1980, 23, 5, 581 - 590.</p><p>Shoenfeld Y. Anti-DNA antibodies: is DNA the self antigen or a shelf antigen, or are all autoimmune diseases immunogen driven? Academ. Press, San Diego, USA, 1997, 139-148.</p><p>Shuster A., Gololobov G., Kvashuk O. et al. DNA hydrolyzing autoantibodies. Science, 1992,1 (256), 665-667.</p><p>Tan E.M., Cohen A, Fries D. et al. The 1982 revised criteria for classification of systemic lupus erythematosus. Arthr. Rheum., 1982, 25, 1271-1277.</p><p>Villarreal G.M., Drekard C., Villa A.R. et al. Prevalence of 13 autoantibodies and of the 16/6 and related pathogenic idiotypes in 465 patients with SLE and their relationship with disease activity. Lupus, 1997, 6(5), 425-435.</p><p>Zamulaeva I.A., Lekakh I.V., Kiseleva V.I. et al. Natural hidden antibodies reacting with DNA or cardiolipin bind to thymocytes and evoke their death. FEBS Lett., 1997, 413(2), 231-235.</p></div><br />
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For citations:
Naumova T.E., Durova O.M., Gabibov A.G., Alelcberova Z.S., Suchkov S.V. DNA-abzymes in autoimmune diseases in clinic and experiment. Rheumatology Science and Practice. 2003;41(1):11-14. (In Russ.) https://doi.org/10.14412/1995-4484-2003-1125
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