Antilipide antibodies cofactor in syphilis, Lyme borreliosis and autoimmune diseases
https://doi.org/10.14412/1995-4484-2003-1128
Abstract
Objective. To study (32 glycoprotein 1 contribution to frequency of aCL in pts with autoimmune and some infectious diseases. Methods. Antibodies to different phospholipids were tested by immune-enzyme method (IEM) in serum of 92 pts: 20 of them had systemic lupus erythematosus (SLE), 15 Sjogren’s disease (SD), 20 rheumatoid arthritis (RA), 20 syphilis and 17 Lyme disease (LD). Pts with syphilis and LD did not have clinical signs of autoimmune disease. Stimulation of aCL test in IEM was performed after previous cardiolipin incubation on microtitrated plates with electrophoretic pure p2 glycoprotein 1. Results. aCL were mostly revealed in serum of patients with SLE and syphilis, less often in SD. In aCL- positive serums antibodies to some other phospholipids were found. Mean values of stimulating aCL test in IEM after previous incubation with pure |32-glycoprotein 1 in autoimmune diseases were higher than in infection. aCL division into cofactor «dependent» and «independent» or autoimmune and infectious types seems to be not final.
About the Authors
B VoicechovskayaLaboratoriya mikrobiologii i serologii
J Zabek
Laboratoriya mikrobiologii i serologii
References
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For citations:
Voicechovskaya B., Zabek J. Antilipide antibodies cofactor in syphilis, Lyme borreliosis and autoimmune diseases. Rheumatology Science and Practice. 2003;41(1):24-26. (In Russ.) https://doi.org/10.14412/1995-4484-2003-1128
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