Sildenafil in the treatment of Raynaud’s syndrome
https://doi.org/10.14412/1995-4484-2009-1311
Abstract
Синдром Рейно (СР) является чрезмерной вазоспастической реакцией на воздействие холода или эмоциональное напряжение. Клинически синдром проявляется резко очерченными участками изменения окраски кожи (побеление/посинение) пальцев кистей и стоп. В популяции, особенно в странах с холодным климатом, отмечается значительная распространенность СР, которая достигает 3-5% [1]. Различают первичный, или идиопатический, и вторичный, ассоциированный с другими заболеваниями, СР. Первичный СР характеризуется симметричностью атак вазоспазма, отсутствием изъязвлений и некрозов тканей, отсутствием признаков других заболеваний, нормальной капилляроскопической картиной, отрицательными результатами теста на антинуклеарные антитела и нормальным уровнем СОЭ [2]. При вторичном СР атаки вазоспазма обычно бывают более интенсивными, могут сопровождаться сильной болью, часто развиваются выраженные ишемические повреждения тканей в виде рецидивирующих дигитальных и иных кожных изъязвлений, гангрены фаланг пальцев кистей и стоп [3].
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For citations:
Alekperov R.T. Sildenafil in the treatment of Raynaud’s syndrome. Rheumatology Science and Practice. 2009;47(3):38-45. (In Russ.) https://doi.org/10.14412/1995-4484-2009-1311
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