Роль цитокиновой сети в регуляции воспаления при различных вариантах ювенильного артрита
Аннотация
Хронические артриты у детей являются важной проблемой современной педиатрии в силу того, что эти тяжелые заболевания существенно нарушают качество жизни ребенка и его родителей, требуют немалых экономических затрат на лечение и нередко приводят к инвалидности ребёнка. Этиология этих заболеваний в настоящее время окончательно не расшифрована, существует лишь ряд более или менее обоснованных гипотез на этот счет. Лечение ювенильных артритов (ЮА), несмотря на значительные успехи, достигнутые в последние десятилетия, также далеко от совершенства: подбор медикаментозных средств зачастую производится эмпирически, не всегда врачу удается контролировать патологический процесс и предотвратить серьезные функциональные нарушения. Любой значительный прорыв в терапии хронических артритов у детей может быть достигнут только при условии прогресса в понимании патогенеза этих заболеваний и механизмов действия лекарственных препаратов, направленных на конкретные звенья патологического процесса. Появление в последние годы новых классов лекарственных препаратов, так называемых биологических противовоспалительных агентов, особенно остро ставит вопрос об участии определенных механизмов в формировании различных форм ЮА, без чего невозможно грамотное назначение данных лекарств у конкретного больного.
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Для цитирования:
Федоров Е.С., Салугина С.О., Кузьмина Н.Н. Роль цитокиновой сети в регуляции воспаления при различных вариантах ювенильного артрита. Научно-практическая ревматология. 2009;47(3):74-89. https://doi.org/10.14412/1995-4484-2009-1316
For citation:
Fedorov E.S., Salugina S.O., Kuzmina N.N. Role of cytokine net in regulation of inflammation in different variants of juvenile arthritis. Rheumatology Science and Practice. 2009;47(3):74-89. (In Russ.) https://doi.org/10.14412/1995-4484-2009-1316
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