Varfarin in the complex treatment of antiphospholipid syndrome: preliminary results
https://doi.org/10.14412/1995-4484-2003-1358
Abstract
Objective. To assess efficacy and tolerance of varfarin in prophylaxis and therapy of thrombotic complications in patients with antiphospholipid syndrome (APS). Methods. 20 pts with APS (5 male and 15 female) received varfarin during a year. 8 of them had primary APS (PAPS) and 12 -systemic lupus erythematosus with APS (SLE+APS). 2 other pts (I with SLE+APS and I with PAPS) received varfarin during the last 4 years. Nobody from 9 pts with PAPS received corticosteroids (CS). In SLE+APS pts CS dose varied from 4 to 20 mg/day and was not increased during follow up. During the study prothrombine time (PT) was examined with thromboplastin ( manufactured by Renam) having international sensitivity index 1,2 and international normalization relation (INR). Depending on treatment scheme APS pts were divided into 3 groups. Group 1 included 8 pts with INR<2,0, Group 2-7 with INR >3,0, group 3 - 7 pts with INR<2,0 receiving as additional treatment thrombo ASS 100 mg/day and vasonit from 600 to 1200 mg/day. Results. Two pts with INR = 1,8 had thrombosis recurrence (due to leg thrombophlebitis). There were no recurrences in other groups. 2 from 22 pts had "large" bleedings. "Small" bleedings episodes were noted in 7 from 22 pts. Largely that were subcutaneous bleedings (in 4 pts) no more than 5 cm of size. Two pts receiving varfarin with INR 1,8 and 2,4 had renal colic. Conclusion. Our preliminary results prove the necessity of inclusion of varfarin in the treatment of pts with APS and thrombosis but intensive anticoagulant effect is not always desired.
About the Authors
T M ReshetnyakI E Shirokova
I B Shtivelband
T A Lisicina
E A Aleksandrova
E N Aleksandrova
References
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For citations:
Reshetnyak T.M., Shirokova I.E., Shtivelband I.B., Lisicina T.A., Aleksandrova E.A., Aleksandrova E.N. Varfarin in the complex treatment of antiphospholipid syndrome: preliminary results. Rheumatology Science and Practice. 2003;41(3):37-41. (In Russ.) https://doi.org/10.14412/1995-4484-2003-1358
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