Preview

Rheumatology Science and Practice

Advanced search

Mineral bone density comparative assessment in patients with systemic lupus erythematosus treated and not treated with glucocorticoids

https://doi.org/10.14412/1995-4484-2004-1377

Abstract

Objective. To compare bone mineral density (BMD) in pts with systemic lupus erythematosus (SLE), treated and untreated by glucocorticoids (GC). Matherial and Methods. 30 females with reliable SLE were examined (APA, 1982), 15 had GC (prednisolone 7.5-60mg/day, median cumulative dose 10.7±6.6g) (1st group), 15 others did not take GC (2nd group). Groups were comparable by age, SLE course duration, body weight. All were females with normal menses period. BMD was assessed in low back vertebral region and femoral neck in standard projections on dichromatic X-ray densitometer QDR-1000 Plus (Hologic, USA) in absolute values (g/cm2) and T-index. Results. BMD in low back was statistically reliably lower in the 1st group as compared with the 2nd (0,918±0,118 and 1,036±0,156; p=0,027). In the left femoral neck there were no differences in mineralization of bone tissue (0,769±0,167 and 0,807±0,227; p=0,568), BMD decreasing in the studied bone region reliably prevailed among pts of the 1st group (n=ll) as compared with the 2nd (n=2) (p=0.003). Conclusion. SLE pis treated by GC demonstrated reliably lower indices of BMD in LI-L4 as compared with pts who were not treated by GC.

References

1. <div><p>Антелава О.А. Влияние высоких доз глюкокортикоидов на минеральную плотность костной ткани при дерматомиозите. Дисс.к.м.н. М., 2002.</p><p>Беневоленская Л.И., Михайлов Е.Е. Руководство по остеопорозу. М., БИНОМ, 2003, 11.</p><p>Насонов ЕЛ., Скрипникова И.А., Насонова В.А Проблема остеопороза в ревматологии, М., СТИН, 1997,429.</p><p>Насонов Е.Л., Чичасова Н.В., Ковалев В.Ю. Глюко- кортикоиды в ревматологии. М., 1998,160.</p><p>Bressot С., Meunier P.J., Chapuy М.С. et al. Histomorphomeiric profile, pathophysiology and reversibility of corticosteroid - induced osteoporosis. Metab. Bone Dis., 1979. I, 303-311.</p><p>Houssiau F. A., Lefebvre C., Depresseux G. et al. Trabecular and cortical bone loss in systemic lupus erythematosus. Вг. J. Rheumat., 1996, 35, 244-247.</p><p>Jardinet D., Lefebvre С., Depresseux G. et al. Longitudinal analysis of bone mineral density in pre-menopausal female systemic lupus erythematosus patients: deleterious role of glucocorticid therapy at the lumbar spine. Rheumat., 2000, 39, 389-392.</p><p>Kalla A.A., Faatar A.A., Jessop S.J. Loss of trabecular bone mineral density in systemic lupus erythematosus. Arthr. Rheum., 1993,’36, 1726-1774.</p><p>Kipen Y., Buchbinder R., Forber A. Prevalence of reduced bone mineral density in systemic lupus erythematosus and the role of steroids. J. Rheumat., 1997, 24, 1922-1929.</p><p>Lane N.E., Cunnane Gaye. Steroid - induced osteoporosis in svstemic lupus erythematosus. Rheum. Dis., 2000, 26, 311-329.</p><p>Li Ek, Tam L.S., Young R.P. et al. Loss of bone mineral density in Chinese pre-menopausal women with systemic lupus erythematosus treated with corticosteroids. Br. J. Rheumat., 1998, 37, 405-410.</p><p>Pons F., Peris N. Guanabens N. et al. The effect of systemic lupus erythematosus and long-term steroid therapy on bone mass in pre-menopausal women. Br. J. Rheumat., 1995, 34, 742-746.</p><p>Sambook P., Eisman I, Yeates M. et al. Sex hormone status and osteoporosis in postmenopausal women with rheumatoid artraitis. Arthritis Rheum., 1988, 31, 973-978.</p><p>Sambrook P.N., Kempler S., Birmingham J. et al. Corticosteroid effects on proximal femur bone loss. Bone Min. Res., 1990, 5, 1211 - 1231.</p><p>Sels F., Dequrker J., Verwilghen J. SLE and osteoporosis: dependence and/or independence on glucocorticoids. Lupus, 1996, 89-92.</p><p>Sinigaglia L., Varena М., Binelli L. et al. Bone mass in systemic lupus erythematosus. Exp. Rheumatol., 2000, 18 (suppl.21), 27-34.</p><p>Tan E. М., Cohen A. S., Fries J. P. et al. The 1982 revised criteria for the classification of systematic lupus erythematosus. Arthr. Rheum., 1982, 25, 1271-1277.</p></div><br />


Review

For citations:


Archakova L.A., Kosheleva N.M., Smirnov A.V., Alekberova Z.S. Mineral bone density comparative assessment in patients with systemic lupus erythematosus treated and not treated with glucocorticoids. Rheumatology Science and Practice. 2004;42(1):19-23. (In Russ.) https://doi.org/10.14412/1995-4484-2004-1377

Views: 708


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 1995-4484 (Print)
ISSN 1995-4492 (Online)