Новые подходы к фармакотерапии ревматоидного артрита: тофацитиниб
Аннотация
К крупным достижениям фармакологии XXI в. относится разработка нового класса лекарственных средств, представляющих собой низкомолекулярные (<1 кДа) химически синтезированные вещества (small mole- cules), предназначенные для перорального приема. Их точка приложения – тирозинкиназы, ферменты, уча- ствующие в регуляции внутриклеточной сигнализации, определяющей биологическую активность цитоки- нов. Особый интерес представляет тофацитиниб (ТОФА; Tofacitinib, Яквинус; Пфайзер), первый перораль- ный обратимый ингибитор JAK, разрешенный к применению для лечения ревматоидного артрита (РА). Клиническая эффективность и низкая токсичность ТОФА доказаны в серии РПКИ фазы III, объединенных акронимом ORAL, в которые вошли более 5000 пациентов с РА. Необходимы дальнейшие исследования, на- правленные на оценку эффективности и безопасности ТОФА в процессе длительного применения в реаль- ной клинической практике (в том числе в рамках национальных регистров), у пациентов с различными фор- мами РА и коморбидными заболеваниями. Целесообразно проведение «стратегических» исследований ТОФА, спланированных в соответствии с концепцией «Лечение до достижения цели»
Об авторе
Е. Л. Насонов
ФГБУ «Научно- исследовательский институт ревматологии им. В.А. Насоновой РАМН», Москва, Россия
Россия
Россия
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Для цитирования:
Насонов Е.Л. Новые подходы к фармакотерапии ревматоидного артрита: тофацитиниб. Научно-практическая ревматология. 2014;52(2):209-221. https://doi.org/10.14412/1995-4484-2014-209-221
For citation:
Nasonov E.L. NEW APPROACHES TO PHARMACOTHERAPY OF RHEUMATOID ARTHRITIS: TOFACITINIB. Rheumatology Science and Practice. 2014;52(2):209-221. (In Russ.) https://doi.org/10.14412/1995-4484-2014-209-221
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