CHRONIC RECURRENT MULTIFOCAL OSTEOMYELITIS IN THE PRACTICE OF A RHEUMATOLOGIST: FAMILIAL CASES
https://doi.org/10.14412/1995-4484-2015-568-572
Abstract
The paper describes a female patient who had a concurrence of the signs of juvenile idiopathic arthritis (JIA) and chronic recurrent multifocal osteomyelitis (CRMO). The latter was also diagnosed in her mother and brother. There is reason to suggest that CHMO and JIA may be a clinical reflection of identical pathology turning out to be the overlap syndromes of a single autoinflammatory disease. When making a differential diagnosis if there are cases of atypical JIA without signs of autoimmune diseases, CRMO is well to bear in mind.
About the Authors
R. U. Shayakhmetova
V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia 34A, Kashirskoe Shosse, Moscow 115522
Russian Federation
Russian Federation
Ya. A. Sigidin
V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia 34A, Kashirskoe Shosse, Moscow 115522
Russian Federation
Russian Federation
N. N. Kuzmina
V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia 34A, Kashirskoe Shosse, Moscow 115522
Russian Federation
Russian Federation
A. V. Smirnov
V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia 34A, Kashirskoe Shosse, Moscow 115522
Russian Federation
Russian Federation
References
1. Stern SM, Ferguson PJ. Autoinflammatory bone diseases. Rheum Dis Clin N Am. 2013;39:735–49. doi: 10.1016/j.rdc.2013.05.002
2. Giedion A, Holthusen W, Masel LF, et al. Subacute and chronic «symmetrical» osteomyelitis. Ann Radiol (Paris). 1972;15:329–42.
3. Probst FP, Bjorksten B, Gustavson KH. Radiological aspect of chronic recurrent multifocal osteomyelitis. Ann Radiol (Paris). 1978;21:115–25.
4. Jansson A, Renner ED, Ramer J, et al. Classification of nonbacterial osteitis: retrospective study of clinical, immunological and genetic aspects in 89 patients. Rheumatology (Oxford). 2007;46:154–60. doi: 10.1093/rheumatology/kel190
5. Girschick HJ, Raab P, Surbaum S, et al. Chronic non-bacterial osteomyelitis in children. Ann Rheum Dis. 2005;64:279–85. doi: 10.1136/ard.2004.023838
6. Gikas PD, Islam L, Aston W, et al. Nonbacterial osteitis: a clinical, histopathological, and imaging study with a proposal for protocol-based management of patients with this diagnosis. J Orthop Sci. 2009;14:505–16. doi: 10.1007/s00776-009-1381-4
7. Кузьмина НН, Салугина СО, Федоров ЕС. Аутовоспалительные заболевания и симптомы у детей: Учебно-методическое пособие. Москва: ИМА-ПРЕСС; 2012. С. 70–6 [Kuz'mina NN, Salugina SO, Fedorov ES. Autovospalitel'nye zabolevaniya i simptomy u detei: Uchebnometodicheskoe posobie [Autoinflammatory diseases and symptoms in children: Teaching manual]. Moscow: IMA-PRESS; 2012. P. 70–6].
8. Hedrich CM, Hofmann SR, Pablik J, et al. Autoinflammatory bone disorders with special focus on chronic recurrent multifocal osteomyelitis (CRMO). Pediatr Rheumatol Online J. 2013;11:47–9. doi: 10.1186/1546-0096-11-47
9. Hedrich CM, Hahn G, Girschick HJ, Morbach H. A clinical and pathomechanistic profile of chronic nonbacterial osteomyelitis/chronic recurrent multifocal osteomyelitis and challenges facing the field. Expert Rev Clin Immunol. 2013;9(9):845–54. doi: 10.1586/1744666X.2013.824670
10. Khan MA, Osborne NJ, Anaspure R, et al. Clavicular swelling - classic presentation of chronic non-bacterial osteomyelitis. Arch Dis Child. 2012;98:238. doi: 10.1136/archdischild-2012-303187
11. Mandell GA, Contreras SJ, Conard K, et al. Bone scintigraphy in the detection of chronic recurrent multifocal osteomyelitis. J Nucl Med. 1998;39:1778–83.
12. Khanna G, Sato TS, Ferguson P. Imaging of chronic recurrent multifocal osteomyelitis. Radiographics. 2009;29:1159–77. doi: 10.1148/rg.294085244
13. Borzutzky A, Stern S, Reiff A, et al. Pediatric chronic nonbacterial osteomyelitis. Pediatrics. 2012;130:1190–7. doi: 10.1542/peds.2011-3788
14. Morbach H, Dick A, Beck C, et al. Association of chronic nonbacterial osteomyelitis with Crohn's disease but not with CARD15 gene variants. Rheumatol Int. 2010;30:617–21. doi: 10.1007/s00296-009-1029-x
15. De Sanctis S, Nozzi M, Del Torto M, et al. Autoinflammatory syndromes: diagnosis and management. Ital J Pediatr. 2010;36:57. doi: 10.1186/1824-7288-36-57
16. Vittecoq O, Said LA, Michot C, et al. Evolution of chronic recurrent multifocal osteitis toward spondylarthropathy over the long term. Arthritis Rheum. 2000;43:109–19. doi: 10.1002/1529-0131(200001)43:1<109::AID-ANR14>3.0.CO;2-3
17. Schilling F, Wagner AD. Azithromycin: an anti-inflammatory effect in chronic recurrent multifocal osteomyelitis? A preliminary report. Z Rheumatol. 2000;59:352–3. doi: 10.1007/s003930070059
18. Ozen S, Bilginer Y. A clinical guide to autoinflammatory diseases: familial Mediterranean fever and next-of-kin. Nat Rev Rheumatol. 2014;10:135–47. doi: 10.1038/nrrheum.2013.174
19. Hofmann SR, Schwarz T, Moller JC, et al. Chronic non-bacterial osteomyelitis is associated with impaired Sp1 signaling, reduced IL10 promoter phosphorylation, and reduced myeloid IL-10 expression. Clin Immunol. 2011;141:317–27. doi: 10.1016/j.clim.2011.08.012
20. Ferguson PJ, Bing X, Vasef MA, et al. A missense mutation in pstpip2 is associated with the murine autoinflammatory disorder chronic multifocal osteomyelitis. Bone. 2006;38:41–7. doi: 10.1016/j.bone.2005.07.009
21. Majeed H, Kalaawi M, Mohanty D, et al. Congenital dyserythropoietic anemia and chronic recurrent multifocal osteomyelitis in three related children and the association with Sweet syndrome in two siblings. J Pediatr. 1989;115:730–4. doi: 10.1016/S0022-3476(89)80650-X
22. Majeed HA, Al-Tarawna M, El-Shanti H, et al. The syndrome of chronic recurrent multifocal osteomyelitis and congenital dyseruthropoietic anaemia. Report of a new family and a review. Eur J Pediatr. 2001;160:705–10. doi: 10.1007/s004310100799
23. Gattorno M, Federici S, Pelagatti MA, et al. Diagnosis and management of autoinflammatory diseases in childhood. J Clin Immunol. 2008;28:73–83. doi: 10.1007/s10875-008-9178-3
24. Miettunen PM, Wei X, Kaura D, et al. Dramatic pain relief and resolution of bone inflammation following pamidronate in 9 pediatric patients with persistent chronic recurrent multifocal osteomyelitis (CRMO). Pediatr Rheumatol Online J. 2009;7:2. doi: 10.1186/1546-0096-7-2
25. Vastert SJ, Kuis W, Grom AA. Systemic JIA: New developments in the understanding of the pathophysiology and therapy. Best Pract Res Clin Rheumatol. 2009;23:655–64. doi: 10.1016/j.berh.2009.08.003
26. Femiano F, Lanza A, Buonaiuto C, et al. Oral aphthous-like lesions, PFAPA syndrome: a review. J Oral Pathol Med. 2008;37:319–23. doi: 10.1111/j.1600-0714.2008.00634.x
Review
For citations:
Shayakhmetova R.U., Sigidin Ya.A., Kuzmina N.N., Smirnov A.V. CHRONIC RECURRENT MULTIFOCAL OSTEOMYELITIS IN THE PRACTICE OF A RHEUMATOLOGIST: FAMILIAL CASES. Rheumatology Science and Practice. 2015;53(5):568-572. (In Russ.) https://doi.org/10.14412/1995-4484-2015-568-572
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