Features of systemic sclerosis-rheumatoid arthritis overlap syndrome (SS-RA overlap syndrome)
https://doi.org/10.14412/1995-4484-2007-18-23
Abstract
Objective. To reveal clinico-laboratory, immunologic and immunogenetic features of systemic sclerosis-rheumatoid arthritis overlap syndrome (SS-RA).
Material and methods. 32 pts with SS-RA (1 male, 31 female) aged 22 to 74 years with disease onset at 18 to 69 years and disease duration from 1 to 35 years were included. Complex laboratory and instrumental examination was performed including nailfold capillaroscopy. A part of pts was also evaluated with magnetic resonance imaging of hands. Serum level of rheumatoid factor, antinuclear factor, circulating immune complexes, C-reactive protein, antibodies to cyclic citrullinated peptide (ACCP) was evaluated. Genotyping of DRB1 alleles was performed.
Results. Characteristic features of SS-RA were prevalence of limited skin damage, less prominent peripheral and visceral symptoms of SS, presence of anti-topoisomerase antibodies and erosive arthritis, high laboratory and immunological activity, more frequent association with DRB1*01.
Conclusion. SS-RA possesses its own clinical features and can be considered as a distinct subtype of SS.
About the Authors
O. V. Desinova
ГУ Институт ревматологии РАМН, Москва
Russian Federation
Russian Federation
M. N. Starovoytova
ГУ Институт ревматологии РАМН, Москва
Russian Federation
Russian Federation
I. A. Guseva
ГУ Институт ревматологии РАМН, Москва
Russian Federation
Russian Federation
A. A. Novikov
ГУ Институт ревматологии РАМН, Москва
Russian Federation
Russian Federation
E. N. Alexandrova
ГУ Институт ревматологии РАМН, Москва
Russian Federation
Russian Federation
N. G. Guseva
ГУ Институт ревматологии РАМН, Москва
Russian Federation
Russian Federation
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Review
For citations:
Desinova O.V., Starovoytova M.N., Guseva I.A., Novikov A.A., Alexandrova E.N., Guseva N.G. Features of systemic sclerosis-rheumatoid arthritis overlap syndrome (SS-RA overlap syndrome). Rheumatology Science and Practice. 2007;45(4):18-23. (In Russ.) https://doi.org/10.14412/1995-4484-2007-18-23
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