COGAN'S SYNDROME: SUCCESS OF IMMUNOSUPPRESSIVE THERAPY
https://doi.org/10.14412/1995-4484-2016-598-600
Abstract
Cogan's syndrome is a rare disease from a group of systemic vasculitides with variable vascular involvement. It is a concurrence of ophthalmic symptoms and audiovestibular disorders (Meniere's disease and sensorineural hearing loss). There is often fever, arthralgia or arthritis; neurological disorders and aortitis with the development of aortic aneurysms are encountered. Hearing loss is frequently irreversible. Changes in the organ of vision usually occur favorably.
The paper describes a case of Cogan's syndrome in a 33-year-old patient. The disease is manifested by papilledema, conjunctivitis, acute sensorineural deafness with rapid loss of hearing, and microfocal changes in the brain, as detected by computed tomography. Pulse therapy with glucocorticoids and cyclophosphamide led to a rapid and obvious regression of all symptoms. The case is of interest due to the rare occurrence of the disease and to the success of performed therapy. The description stresses the importance of a rheumatologist's consultation and the need for the collective management of young patients with clinical presentations of acute sensorineural hearing loss.
About the Authors
N. A. Morova
Omsk State Medical University
Russian Federation
Russian Federation
Nataliya Morova.
12, LeninSt., Omsk644043
T. V. Kropotina
Regonal Clinical Hospital
Russian Federation
Russian Federation
3, BerezovayaSt., Omsk 644111
Yu. V. Arbuzova
Regonal Clinical Hospital
Russian Federation
Russian Federation
3, BerezovayaSt., Omsk 644111
References
1. Morgan RF, Baumgartner CJ. Meniers disease complicated by recurrent interstitial keratitis: excellent results following cervical ganglionectomy. West J Surg. 1934;42:628-31.
2. Cogan DG. Syndrome of nonsyphilitic interstitial keratitis and vestibulo-auditory symptoms. Arch Ophthalmol. 1945;33:144-9. doi: 10.1001/archopht.1945.00890140064007
3. Haynes BF, Kaiser-Kupfer MI, Mason P, Fauci AS. Cogan syndrome: studies on thirteen patients, longterm follow up, and a review of the literature. Medicine. 1980;59:426-41. doi: 10.1097/00005792-198011000-00003
4. Grasland A, Pouchot J, Hachulla E, et al. Typical and atypical Cogans syndrome: 32 cases and review of literature. Rheumatology (Oxford). 2004;43(8):1007-15. doi: 10.1093/rheumatology/keh228
5. McDonald TJ, Vollertsen RS, Younge BR. Cogan's syndrome: audiovestibular involvement and prognosis in 18 patients. Laryngoscope. 1985;95(6):650-4.
6. Massinger C, Keilmann A. Cogan-I-Syndrome. A rare differential diagnosis in progressive sensorineural hearing loss. Neurohospitalist. 2003;1:66-70.
7. Vollertsen RS. Vasculitis and cogans syndrome. Rheum Dis Clin North Am. 1990;16:433-9.
8. Kessel A, Vadasz Z, Toubi E. Cogan syndrome-pathogenesis, clinical variants and treatment approaches. Autoimmun Rev. 2014;13(4-5):351-4. doi: 10.1016/j.autrev.2014.01.002
9. Espinoza GM, Prost A. Cogan's syndrome and other ocular vasculitides. Curr Rheumatol Rep. 2015;17(4):24. doi: 10.1007/s11926-015-0499-y
10. Cundiff S, Kansal S, Kumar A, et al. Cogan' syndrome: a cause of progressive hearing deafness. Am J Otolaringol. 2006;27(1):68-70. doi: 10.1016/j.amjoto.2005.07.006
11. Gluth MB, Baratz KH, Matteson EL, Driscoll CL. A retrospective review of 60 patients throughout a half century. Mayo Clin Proc. 2006;81(4):483-8. doi: 10.4065/81.4.483
12. Tayer-Shifman OE, Ilan O, Tovi H, Tal Y. Cogan's syndrome –clinical guidelines and novel therapeutic approaches. IMMU. 2014;47(1):65-72. doi: 10.1007/s12016-013-8406-7
Review
For citations:
Morova N.A., Kropotina T.V., Arbuzova Yu.V. COGAN'S SYNDROME: SUCCESS OF IMMUNOSUPPRESSIVE THERAPY. Rheumatology Science and Practice. 2016;54(5):598-600. (In Russ.) https://doi.org/10.14412/1995-4484-2016-598-600
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