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Эффективность и безопасность применения ритуксимаба при ревматоидном артрите (новые данные)

https://doi.org/10.14412/1995-4484-2017-420-428

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Аннотация

Ревматоидный артрит (РА) – аутоиммунное ревматическое заболевание, характеризующееся хроническим эрозивным артритом (синовитом) и системным воспалительным поражением внутренних органов, приводящим к ранней инвалидизации и ухудшению качества жизни пациентов. Накопленные данные об эффективности, безопасности и экономической эффективности применения анти-В-клеточной терапии позволяют выделить ритуксимаб (РТМ) как чрезвычайно важный препарат первой или второй линии терапии генно-инженерными биологическими препаратами, после неэффективного лечения ингибиторами фактора некроза опухоли α (ФНОα). В связи с этим по-прежнему актуальной остается проблема персонифицированного выбора схемы лечения в каждом конкретном случае. Опыт применения РТМ в клинической практике свидетельствует о его высокой эффективности в отношении как клинических проявлений, так и влияния на качество жизни пациентов при развернутом РА, характеризующемся лекарственной резистентностью к базисным противовоспалительным препаратам и ингибиторам ФНОα, а также при раннем РА. В настоящее время в литературе представлено большое количество данных, посвященных роли предшествующей терапии, влиянию стадии РА при назначении и различных курсовых доз РТМ в эффективности терапии РА, часть из которых будет обсуждена в данном обзоре.

Об авторах

Д. А. Кусевич
ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России
Россия

аспирант 1-го года кафедры ревматологии Института профессионального образования ФГАОУ ВО «Первый  Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России

119991 Москва, ул. Трубецкая, 8, стр. 2



А. С. Авдеева
ФГБНУ «Научно- исследовательский институт ревматологии им. В.А. Насоновой»
Россия

научный сотрудник лаборатории стандартизации терапии ревматических заболеваний ФГБНУ НИИР им. В.А. Насоновой, канд. мед. наук

115522 Москва, Каширское шоссе, 34А



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Для цитирования:


Кусевич Д.А., Авдеева А.С. Эффективность и безопасность применения ритуксимаба при ревматоидном артрите (новые данные). Научно-практическая ревматология. 2017;55(4):420-428. https://doi.org/10.14412/1995-4484-2017-420-428

For citation:


Kusevich D.A., Avdeeva A.S. THE EFFICACY AND SAFETY OF RITUXIMAB IN RHEUMATOID ARTHRITIS: NEW EVIDENCE. Rheumatology Science and Practice. 2017;55(4):420-428. (In Russ.) https://doi.org/10.14412/1995-4484-2017-420-428

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ISSN 1995-4484 (Print)
ISSN 1995-4492 (Online)