Стратегия снижения дозы и отмены генно-инженерных биологических препаратов при ревматоидном артрите в стадии ремиссии

Рекомендации по ведению больных ревматоидным артритом (РА) предусматривают усиление терапии при недостаточной ее эффективности; в то же время при успешном достижении поставленной цели может обсуждаться вопрос о снижении интенсивности лечения. В рекомендациях EULAR предусматривается возможность уменьшения дозы и даже отмены генно-инженерных биологических препаратов (ГИБП), особенно при проведении сочетанной терапии ГИБП и базисными противовоспалительными препаратами (БПВП). Однако стратегия такого изменения терапии еще недостаточно четко определена. В данном обзоре мы хотели бы затронуть вопрос, касающийся не раннего, а развернутого РА у больных с необратимыми изменениями опорно-двигательного аппарата, длительно получающих БПВП и/или ГИБП. При достижении ремиссии решить вопрос о возможности снижения дозы или отмены препарата в таких случаях бывает сложнее, чем при раннем РА.

ревматоидный артрит, генно-инженерные биологические препараты, базисные противовоспалительные препараты, лечение, ремиссия

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