Эффективность и безопасность тофацитиниба при иммуновоспалительных ревматических заболеваниях (часть II)
Аннотация
Разработка «таргетных» пероральных противовоспалительных лекарственных препаратов – ингибиторов Янускиназ (Janus kinase, JAK), первым представителем которых является тофацитиниб (ТОФА), рассматривается как крупное достижение биологии и медицины начала XXI в. В части I обзора были рассмотрены материалы исследований, касающихся эффективности и безопасности ТОФА при ревматоидном артрите (РА). Расширение представлений о механизмах развития и хронизации воспаления, противовоспалительных и иммуномодулирующих эффектах ТОФА на модели РА создало теоретические и клинические предпосылки для изучения эффективности ТОФА при других иммуновоспалительных ревматических заболеваниях (ИВРЗ) и хронических воспалительных «неревматических» болезнях. В части II обзора обобщены новые данные, позволяющие сформировать основные направления дальнейших клинических и фундаментальных исследований, цель которых – расширение показаний и персонификация терапии ингибиторами JAK у пациентов с ИВРЗ.
Об авторах
Е. Л. Насонов
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»;
ФГБОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)
Россия
Россия
научный руководитель, академик РАН, профессор, докт. мед. наук
115522, Москва, Каширское шоссе, 34А
119991, Москва, ул. Трубецкая, 8, стр. 2
А. С. Авдеева
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»
Россия
Россия
научный сотрудник лаборатории стандартизации терапии ревматических заболеваний, канд. мед. наук
115522, Москва, Каширское шоссе, 34А
А. М. Лила
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»;
ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России
Россия
Россия
директор, профессор, докт. мед. наук
115522, Москва, Каширское шоссе, 34А
125993, Москва, ул. Баррикадная, 2/1, стр.1
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Рецензия
Для цитирования:
Насонов Е.Л., Авдеева А.С., Лила А.М. Эффективность и безопасность тофацитиниба при иммуновоспалительных ревматических заболеваниях (часть II). Научно-практическая ревматология. 2020;58(2):214-224. https://doi.org/10.14412/1995-4484-2020-214-224
For citation:
Nasonov E.L., Avdeeva A.S., Lila A.M. EFFICACY AND SAFETY OF TOFACITINIB FOR IMMUNEMEDIATED INFLAMMATORY RHEUMATIC DISEASES (PART II). Rheumatology Science and Practice. 2020;58(2):214-224. (In Russ.) https://doi.org/10.14412/1995-4484-2020-214-224
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