EFFICACY AND SAFETY OF TOFACITINIB FOR IMMUNEMEDIATED INFLAMMATORY RHEUMATIC DISEASES (PART II)
https://doi.org/10.14412/1995-4484-2020-214-224
Abstract
The design of targeted oral anti-inflammatory drugs, such as Janus kinase (JAK) inhibitors, the first representative of which is tofacitinib (TOFA), is considered a major achievement in biology and medicine early in the 21st century. Part I of the review considers the materials of studies evaluating the efficacy and safety of TOFA in rheumatoid arthritis (RA). The expansion of ideas about the mechanisms of development and chronicity of inflammation and the antiinflammatory and immunomodulatory effects of TOFA using a RA model has created theoretical and clinical prerequisites for studying the efficacy of TOFA in other immune-mediated inflammatory rheumatic diseases (IMIRDs) and chronic inflammatory non-rheumatic diseases. Part II of the review summarizes new data that allow one to formulate main areas of further clinical and fundamental studies, the objective of which is to expand indications for and to personalize therapy with JAK inhibitors in patients with IMIRDs.
About the Authors
E. L. Nasonov
V.A. Nasonova Research Institute of Rheumatology;
I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Russian Federation
Russian Federation
34A, Kashirskoe Shosse, Moscow 115522
8, Trubetskaya St., Build. 2, Moscow 119991
A. S. Avdeeva
V.A. Nasonova Research Institute of Rheumatology
Russian Federation
34A, Kashirskoe Shosse, Moscow 115522
Russian Federation
34A, Kashirskoe Shosse, Moscow 115522
A. M. Lila
V.A. Nasonova Research Institute of Rheumatology;
Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia
Russian Federation
Russian Federation
34A, Kashirskoe Shosse, Moscow 115522
2/1, Barrikadnaya St., Build. 1, Moscow 125993
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246. Deverapalli SC, Rosmarin D. The use of JAK inhibitors in the treatment of progressive systemic sclerosis. J Eur Acad Dermatol Venereol. 2018;32(8):e328. doi: 10.1111/jdv.14876
247. Komai T, Shoda H, Hanata N, Fujio K. Tofacitinib rapidly ameliorated polyarthropathy in a patient with systemic sclerosis. Scand J Rheumatol. 2018;47(6):505-6. doi: 10.1080/03009742.2017.1387673
248. Samson M, Corbera-Bellalta M, Audia S, et al. Recent advances in our understanding of giant cell arteritis pathogenesis. Autoimmun Rev. 2017;16(8):833-44. doi: 10.1016/j.autrev.2017.05.014
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250. Tong B, Liu X, Xiao J, Su G. Immunopathogenesis of Behcet's Disease. Front Immunol. 2019;10:665. doi: 10.3389/fimmu.2019.00665
251. Yazici H, Seyahi E, Hatemi G, Yazici Y. Behcet syndrome: a contemporary view. Nat Rev Rheumatol. 2018;14(2):107-19. doi: 10.1038/nrrheum.2017.208
252. Ding Y, Li C, Liu J, et al. Tocilizumab in the treatment of severe and/or refractory vasculo-Behcet's disease: A single-centre experience in China. Rheumatology (Oxford). 2018;57(11):2057-9. doi: 10.1093/rheumatology/key230
253. Atienza-Mateo B, Calvo-Rio V, Beltran E, et al. Anti-interleukin 6 receptor tocilizumab in refractory uveitis associated with Behcet's disease: multicentre retrospective study. Rheumatology (Oxford). 2018;57(5):856-64. doi: 10.1093/rheumatology/kex480
254. Mirouse A, Barete S, Monfort JB, et al. Ustekinumab for Behcet's disease. J Autoimmun. 2017;82:41-6. doi: 10.1016/j.jaut.2017.05.002
255. Rimar D, Alpert A, Starosvetsky E, et al. Tofacitinib for polyarteritis nodosa: a tailored therapy. Ann Rheum Dis. 2016;75(12):2214-6. doi: 10.1136/annrheumdis-2016-209330
256. Wang A, Singh K, Ibrahim W, et al. The Promise of JAK Inhibitors for Treatment of Sarcoidosis and Other Inflammatory Disorders with Macrophage Activation: A Review of the Literature.Yale J Biol Med. 2020 Mar 27;93(1):187-95.
257. Karadeniz H, Gü ler AA, Atas N, et al. Tofacitinib for the treatment for colchicine- resistant familial Mediterranean fever: casebased review. Rheumatol Int. 2020;40(1):169-73. doi: 10.1007/s00296-019-04490-7
258. Montilla AM, Gö mez-Garcia F, Gö mez-Arias PJ, et al. Scoping Review on the Use of Drugs Targeting JAK/STAT Pathway in Atopic Dermatitis, Vitiligo, and Alopecia Areata. Dermatol Ther (Heidelb). 2019;9(4):655-83. doi: 10.1007/s13555-019-00329-y
259. Salas A, Hernandez-Rocha C, Duijvestein M, et al. JAK-STAT pathway targeting for the treatment of inflammatory bowel disease. Nat Rev Gastroenterol Hepatol. 2020 Mar 19. doi: 10.1038/s41575-020-0273-0
260. Nasonov EL, Abdulganieva DI, Fairushina IF. The use of Tofacitinib in the treatment of inflammatory bowel disease. Terapevticheskiy Apkhiv = Therapeutic Archive. 2019;91(2):101-8. doi: 10.26442/00403660.2019.02.000155 (In Russ.)
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For citations:
Nasonov E.L., Avdeeva A.S., Lila A.M. EFFICACY AND SAFETY OF TOFACITINIB FOR IMMUNEMEDIATED INFLAMMATORY RHEUMATIC DISEASES (PART II). Rheumatology Science and Practice. 2020;58(2):214-224. (In Russ.) https://doi.org/10.14412/1995-4484-2020-214-224
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