Preview

Научно-практическая ревматология

Расширенный поиск

Клиническая эффективность биологически активной добавки Картилокс при остеоартрите

https://doi.org/10.47360/1995-4484-2021-450-454

Полный текст:

Аннотация

В работе обсуждаются результаты и обосновывается эффективность фармакотерапии остеоартрита коленных суставов с помощью биологически активной добавки Картилокс, включающей пять активных веществ (коллагеновый пептид II типа, экстракт Босвеллии пильчатой, куркуминоиды, пиперин и гиалуроновую кислоту).

Об авторах

И. С. Дыдыкина
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»
Россия

115522, Российская Федерация, Москва, Каширское шоссе, 34а



П. С. Коваленко
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»
Россия

115522, Российская Федерация, Москва, Каширское шоссе, 34а



Л. В. Меньшикова
Иркутская государственная медицинская академия последипломного образования – филиал ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России
Россия

664049, Российская Федерация, Иркутск, Юбилейный, 100



Список литературы

1. Martel-Pelletier J, Barr AJ, Cicuttini FM, Conaghan PG, Cooper C, Goldring MB, et al. Osteoarthritis. Nat Rev Dis Primers. 2016;2:16072. doi: 10.1038/nrdp.2016.72

2. Bruyère O, Honvo G, Veronese N, Arden NK, Branco J, Curtis EM, et al. An updated algorithm recommendation for the management of knee osteoarthritis from the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO). Semin Arthritis Rheum. 2019;49(3):337-350. doi: 10.1016/j.semarthrit.2019.04.008

3. Насонов ЕЛ (ред.). Ревматология. Российские клинические рекомендации. М.: ГЭОТАР-Медиа; 2017.

4. МУК 2.3.2.721-98.2.3.2. Пищевые продукты и пищевые добавки. Определение безопасности и эффективности биологически активных добавок к пище: методические указания. 1998.

5. Позняковский ВМ, Суханов БП. Биологически активные добавки в современной нутрициологии. Техника и технология пищевых производств. 2009;(2):44-49.

6. Eyre D. Collagen of articular cartilage. Arthritis Res. 2002;4(1):30-35. doi: 10.1186/ar380

7. Xia B, Di Chen, Zhang J, Hu S, Jin H, Tong P. Osteoarthritis pathogenesis: A review of molecular mechanisms. Calcif Tissue Int. 2014;95(6):495-505. doi: 10.1007/s00223-014-9917-9

8. Kuivaniemi H, Tromp G, Prockop DJ. Mutations in collagen genes: causes of rare and some common diseases in humans. FASEB J. 1991;5(7):2052-2060. doi: 10.1096/fasebj.5.7.2010058

9. Mehana EE, Khafaga AF, El-Blehi SS. The role of matrix metalloproteinases in osteoarthritis pathogenesis: An updated review. Life Sci. 2019;234:116786. doi: 10.1016/j.lfs.2019.116786

10. García-Coronado JM, Martínez-Olvera L, Elizondo-Omaña RE, Acosta-Olivo CA, Vilchez-Cavazos F, Simental-Mendía LE, et al. Effect of collagen supplementation on osteoarthritis symptoms: A meta-analysis of randomized placebo-controlled trials. Int Orthop. 2019;43(3):531-538. doi: 10.1007/s00264-018-4211-5

11. Aghamohammadi D, Dolatkhah N, Bakhtiari F, Eslamian F, Hashemian M. Nutraceutical supplements in management of pain and disability in osteoarthritis: A systematic review and meta-analysis of randomized clinical trials. Sci Rep. 2020;10(1):20892. doi: 10.1038/s41598-020-78075-x

12. Bagi CM, Berryman ER, Teo S, Lane NE. Oral administration of undenatured native chicken type II collagen (UC-II) diminished deterioration of articular cartilage in a rat model of osteoarthritis (OA). Osteoarthritis Cartilage. 2017;25(12):2080-2090. doi: 10.1016/j.joca.2017.08.013

13. Di Cesare Mannelli L, Micheli L, Zanardelli M, Ghelardini C. Low dose native type II collagen prevents pain in a rat osteoarthritis model. BMC Musculoskelet Disord. 2013;14:228. doi: 10.1186/1471-2474-14-228

14. Van Vijven JP, Luijsterburg PA, Verhagen AP, van Osch GJ, Kloppenburg M, Bierma-Zeinstra SM. Symptomatic and chondroprotective treatment with collagen derivatives in osteoarthritis: A systematic review. Osteoarthritis Cartilage. 2012;20(8):809-821. doi: 10.1016/j.joca.2012.04.008

15. Trč T, Bohmová J. Efficacy and tolerance of enzymatic hydrolysed collagen (EHC) vs. glucosamine sulphate (GS) in the treatment of knee osteoarthritis (KOA). Int Orthop. 2011;35(3):341-348. doi: 10.1007/s00264-010-1010-z

16. Lugo JP, Saiyed ZM, Lane NE. Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee osteoarthritis symptoms: A multicenter randomized, double-blind, placebo-controlled study. Nutr J. 2016;15:14. doi: 10.1186/s12937-016-0130-8

17. Sengupta K, Alluri KV, Satish AR, Mishra S, Golakoti T, Sarma KV, et al. A double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin for treatment of osteoarthritis of the knee. Arthritis Res Ther. 2008;10(4):R85. doi: 10.1186/ar2461

18. Gupta RC, Lall R, Srivastava A, Sinha A. Hyaluronic acid: Molecular mechanisms and therapeutic trajectory. Front Vet Sci. 2019;6:192. doi: 10.3389/fvets.2019.00192

19. Tashiro T, Seino S, Sato T, Matsuoka R, Masuda Y, Fukui N. Oral administration of polymer hyaluronic acid alleviates symptoms of knee osteoarthritis: A double-blind, placebo-controlled study over a 12-month period. Sci World J. 2012;2012:167928. doi: 10.1100/2012/167928

20. Nelson KM, Dahlin JL, Bisson J, Graham J, Pauli GF, Walters MA. The essential medicinal chemistry of curcumin. J Med Chem. 2017;60(5):1620-1637. doi: 10.1021/acs.jmedchem.6b00975

21. Kocaadam B, Şanlier N. Curcumin, an active component of turmeric (Curcuma longa), and its effects on health. Crit Rev Food Sci Nutr. 2017;57(13):2889-2895. doi: 10.1080/10408398.2015.1077195

22. Rahmani AH, Alsahli MA, Aly SM, Khan MA, Aldebasi YH. Role of curcumin in disease prevention and treatment. Adv Biomed Res. 2018;7:38. doi: 10.4103/abr.abr_147_16

23. Giordano A, Tommonaro G. Curcumin and cancer. Nutrients. 2019;11(10):2376. doi: 10.3390/nu11102376

24. Kotha RR, Luthria DL. Curcumin: Biological, pharmaceutical, nutraceutical, and analytical aspects. Molecules. 2019;24(16):2930. doi: 10.3390/molecules24162930

25. Kunnumakkara AB, Bordoloi D, Padmavathi G, Monisha J, Roy NK, Prasad S, et al. Curcumin, the golden nutraceutical: Multitargeting for multiple chronic diseases. Br J Pharmacol. 2017;174(11):1325-1348. doi: 10.1111/bph.13621

26. Pagano E, Romano B, Izzo AA, Borrelli F. The clinical efficacy of curcumin- containing nutraceuticals: An overview of systematic reviews. Pharmacol Res. 2018;134:79-91. doi: 10.1016/j.phrs.2018.06.007

27. He Y, Yue Y, Zheng X, Zhang K, Chen S, Du Z. Curcumin, inflammation, and chronic diseases: How are they linked? Molecules. 2015;20(5):9183-9213. doi: 10.3390/molecules20059183

28. Chin KY. The spice for joint inflammation: anti-inflammatory role of curcumin in treating osteoarthritis. Drug Des Devel Ther. 2016;10:3029-3042. doi: 10.2147/DDDT.S117432

29. Bielak-Zmijewska A, Grabowska W, Ciolko A, Bojko A, Mosieniak G, Bijoch Ł, et al. The role of curcumin in the modulation of ageing. Int J Mol Sci. 2019;20(5):1239. doi: 10.3390/ijms20051239

30. Xu XY, Meng X, Li S, Gan RY, Li Y, Li HB. Bioactivity, health benefits, and related molecular mechanisms of curcumin: Current progress, challenges, and perspectives. Nutrients. 2018;10(10):1553. doi: 10.3390/nu10101553

31. Kunnumakkara AB, Harsha C, Banik K, Vikkurthi R, Sailo BL, Bordoloi D, et al. Is curcumin bioavailability a problem in humans: Lessons from clinical trials. Expert Opin Drug Metab Toxicol. 2019;15(9):705-733. doi: 10.1080/17425255.2019.1650914

32. Shoba G, Joy D, Joseph T, Majeed M, Rajendran R, Srinivas PS. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med. 1998;64(4):353-356. doi: 10.1055/s-2006-957450

33. Madhu K, Chanda K, Saji MJ. Safety and efficacy of Curcuma longa extract in the treatment of painful knee osteoarthritis: A randomized placebo-controlled trial. Inflammopharmacology. 2013;21(2):129-136. doi: 10.1007/s10787-012-0163-3

34. Panahi Y, Rahimnia AR, Sharafi M, Alishiri G, Saburi A, Sahebkar A. Curcuminoid treatment for knee osteoarthritis: A randomized double-blind placebo-controlled trial. Phytother Res. 2014;28(11):1625-1631. doi: 10.1002/ptr.5174

35. Nakagawa Y, Mukai S, Yamada S, Matsuoka M, Tarumi E, Hashimoto T, et al. Short-term effects of highly-bioavailable curcumin for treating knee osteoarthritis: A randomized, double- blind, placebo-controlled prospective study. J Orthop Sci. 2014;19(6):933-939. doi: 10.1007/s00776-014-0633-0

36. Haroyan A, Mukuchyan V, Mkrtchyan N, Minasyan N, Gasparyan S, Sargsyan A, et al. Efficacy and safety of curcumin and its combination with boswellic acid in osteoarthritis: A comparative, randomized, double-blind, placebo-controlled study. BMC Complement Altern Med. 2018;18(1):7. doi: 10.1186/s12906-017-2062-z

37. Kimmatkar N, Thawani V, Hingorani L, Khiyani R. Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee – A randomized double blind placebo controlled trial. Phytomedicine. 2003;10(1):3-7. doi: 10.1078/094471103321648593

38. Sengupta K, Alluri KV, Satish AR, Mishra S, Golakoti T, Sarma KV, et al. A double blind, randomized, placebo controlled study of the efficacy and safety of 5-loxin for treatment of osteoarthritis of the knee. Arthritis Res Ther. 2008;10(4):R85. doi: 10.1186/ar2461

39. Sengupta K, Krishnaraju AV, Vishal AA, Mishra A, Trimurtulu G, Sarma KV, et al. Comparative efficacy and tolerability of 5-loxin and aflapin against osteoarthritis of the knee: A double blind, randomized, placebo controlled clinical study. Int J Med Sci. 2010;7(6):366-377. doi: 10.7150/ijms.7.366

40. Vishal AA, Mishra A, Raychaudhuri SP. A double blind, randomized, placebo controlled clinical study evaluates the early efficacy of aflapin in subjects with osteoarthritis of knee. Int J Med Sci. 2011;8(7):615-622. doi: 10.7150/ijms.8.615

41. Kuptniratsaikul V, Thanakhumtorn S, Chinswangwatanakul P, Wattanamongkonsil L, Thamlikitkul V. Efficacy and safety of Curcuma domestica extracts in patients with knee osteoarthritis. J Altern Complement Med. 2009;15(8):891-897. doi: 10.1089/acm.2008.0186

42. Kuptniratsaikul V, Dajpratham P, Taechaarpornkul W, Buntragulpoontawee M, Lukkanapichonchut P, Chootip C, et al. Efficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: A multicenter study. Clin Interv Aging. 2014;9:451-458. doi: 10.2147/CIA.S58535

43. Bannuru RR, Osani MC, Al-Eid F, Wang C. Efficacy of curcumin and Boswellia for knee osteoarthritis: Systematic review and meta-analysis. Semin Arthritis Rheum. 2018;48(3):416-429. doi: 10.1016/j.semarthrit.2018.03.001

44. Perkins K, Sahy W, Beckett RD. Efficacy of curcuma for treatment of osteoarthritis. J Evid Based Complementary Altern Med. 2017;22(1):156-165. doi: 10.1177/2156587216636747

45. Chin KY. The spice for joint inflammation: anti-inflammatory role of curcumin in treating osteoarthritis. Drug Des Devel Ther. 2016;10:3029-3042. doi: 10.2147/DDDT.S117432

46. Shep D, Khanwelkar C, Gade P, Karad S. Safety and efficacy of curcumin versus diclofenac in knee osteoarthritis: A randomized open-label parallel-arm study. Trials. 2019;20(1):214. doi: 10.1186/s13063-019-3327-2


Для цитирования:


Дыдыкина И.С., Коваленко П.С., Меньшикова Л.В. Клиническая эффективность биологически активной добавки Картилокс при остеоартрите. Научно-практическая ревматология. 2021;59(4):450-454. https://doi.org/10.47360/1995-4484-2021-450-454

For citation:


Dydykina I.S., Kovalenko P.S., Menshikova L.V. Clinical efficacy of dietary supplement Cartilox in osteoarthritis. Rheumatology Science and Practice. 2021;59(4):450-454. (In Russ.) https://doi.org/10.47360/1995-4484-2021-450-454

Просмотров: 122


Creative Commons License
Контент доступен под лицензией Creative Commons Attribution 4.0 License.


ISSN 1995-4484 (Print)
ISSN 1995-4492 (Online)