Course and outcomes of COVID-19 in patients with immunoinflammatory rheumatic diseases: Preliminary data from the NIIR/APP-COVID-19 registry and literature review
https://doi.org/10.47360/1995-4484-2021-666-675
Abstract
The materials of the Russian NIIR/ARP-COVID-19 database, which included adult (over 18 years old) patients with immuno-inflammatory rheumatic diseases (IIRD) who underwent COVID-19 (coronavirus disease 2019), and a literature review concerning the course and outcomes of COVID-19 in patients with these diseases, are presented. From July 17, 2020 to April 23, 2021, 156 messages were received and analyzed. The study group was represented mainly by women (75%). The average age of patients was 52.0±14.8 years, of which 53 (33.9%) patients were aged 60 years and older. The most frequent clinical manifestations of COVID-19 were fever (62.2%), cough (40.4%), anosmia (37.8%), shortness of breath (33.3%). During the course of COVID-19, computed tomography of the chest organs was performed in 143 patients. When assessed on an “empirical” visual scale, stage 0 of lung lesion was observed in 49 (34.3%) patients, stage 1 in 40 (28%), stage 2 in 35 (24.5%), stage 3 in 19 (13.2%), stage 4 in 0. In the study group, a favorable outcome was observed in 137 (97.9%) patients. Fatal outcome was registered in 3 patients. The effect of COVID-19 on the course of IIRD was assessed in 131 patients: in 52 (39.7%) patients, the course of IIRD worsened, in 1 (0.8%) it improved, in 78 (59.5%) there was no effect. Literature data on the risk of infection with the SARS-CoV-2 virus, the course and outcomes of COVID-19 in rheumatic and musculoskeletal diseases are contradictory, which dictates the need to continue collecting data on the rheumatological problems of COVID-19 in the Russian patient population, taking into account international experience.
About the Authors
E. L. NasonovRussian Federation
Evgeny L. Nasonov.
115522, Moscow, Kashirskoye Highway, 34A; 119991, Moscow, Trubetskaya str., 8, building 2.
Competing Interests:
No
B. S. Belov
Russian Federation
Boris S. Belov.
115522, Moscow, Kashirskoye Highway, 34A.
Competing Interests:
No
A. M. Lila
Russian Federation
Aleksander M. Lila.
115522, Moscow, Kashirskoye Highway, 34A; 125993, Moscow, Barrikadnaya str., 2/1, building 1.
Competing Interests:
No
E. S. Aronova
Russian Federation
Evgeniya S. Aronova.
115522, Moscow, Kashirskoye Highway, 34A.
Competing Interests:
No
G. I. Gridneva
Russian Federation
Galina I. Gridneva.
115522, Moscow, Kashirskoye Highway, 34A.
Competing Interests:
No
A. V. Kudryavtseva
Russian Federation
Anastasia V. Kudryavtseva.
115522, Moscow, Kashirskoye Highway, 34A.
Competing Interests:
No
E. V. Sokol
Russian Federation
Evgeniya V. Sokol.
115522, Moscow, Kashirskoye Highway, 34A.
Competing Interests:
No
A. V. Torgashina
Russian Federation
Anna V. Torgashina.
115522, Moscow, Kashirskoye Highway, 34A.
Competing Interests:
No
I. B. Vinogradova
Russian Federation
Irina B. Vinogradova.
432017, Ulyanovsk, Tretyego Internatsionala str., 7.
Competing Interests:
No
D. I. Abdulganieva
Russian Federation
Diana I. Abdulganieva.
420012, Kazan, Burlerova str., 49.
Competing Interests:
No
A. Yu. Zimenko
Russian Federation
Anna Yu. Zimenko.
628408, Surgut, Energetikov str., 24, korpus 2.
Competing Interests:
No
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Nasonov E.L., Belov B.S., Lila A.M., Aronova E.S., Gridneva G.I., Kudryavtseva A.V., Sokol E.V., Torgashina A.V., Vinogradova I.B., Abdulganieva D.I., Zimenko A.Yu. Course and outcomes of COVID-19 in patients with immunoinflammatory rheumatic diseases: Preliminary data from the NIIR/APP-COVID-19 registry and literature review. Rheumatology Science and Practice. 2021;59(6):666-675. (In Russ.) https://doi.org/10.47360/1995-4484-2021-666-675