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Relationship of cytokine level dynamics with longterm results of early rheumatoid arthritis therapy

https://doi.org/10.47360/1995-4484-2022-72-79

Abstract

The aim of the work – to research the relationship between the dynamics of cytokine levels in the early period (the first 12 and 24 weeks) of pharmacotherapy for rheumatoid arthritis (RA) and long-term outcomes in patients with the disease.
Material and methods. The analysis included 93 patients with early RA. The majority of patients were women (n=77), middle-aged (58 [49; 66] years), with an early stage of the disease (the duration of the disease is 7 [4–11.5] months), seropositive according to IgM rheumatoid factor and cyclic citrullinated peptide antibodies, who had high (59.7%) or moderate (38.8%) disease activity.
The concentration of 27 cytokines in the blood serum was determined with the help of multiplex xMAP technology on the Bio-Plex array system analyzer (BIORAD, USA). Repeated clinical examination of patients was carried out after 6 years.
Results. Patients who achieved remission/low disease activity SDAI after 6 years had a lower level of IL-6 (7.7 [7.4; 23.3]), IL-9 (13.5 [9.1; 18.9]) 12 weeks after the start of therapy; lower IL-9 level (12.6 [6.8; 16.2]) 24 weeks after the start of the treatment, compared with the group of patients with moderate and high inflammatory activity (23.5 [12.4; 69.5], 17.8 [15; 29] and 18.5 [14.2; 22.8] respectively).
Findings. The assessment of the level of proinflammatory cytokines (IL-6, IL-17), immunoregulatory cytokine IL-9 allows to evaluate the activity of the disease more fully and identify a group of patients, who needs the therapy intensification.

About the Authors

V. V. Rybakova
V.A. Nasonova Research Institute of Rheumatology
Russian Federation

Valeriya Rybakova

115522, Moscow, Kashirskoye Highway, 34A


Competing Interests:

нет



A. S. Avdeeva
V.A. Nasonova Research Institute of Rheumatology
Russian Federation

Anastasia S. Avdeeva

115522, Moscow, Kashirskoye Highway, 34A


Competing Interests:

нет



D. A. Dibrov
V.A. Nasonova Research Institute of Rheumatology
Russian Federation

Danil A. Dibrov

115522, Moscow, Kashirskoye Highway, 34A


Competing Interests:

нет



Е. L. Nasonov
V.A. Nasonova Research Institute of Rheumatology; I.M. Sechenov First Moscow State Medical University of the Ministry of Health Care of Russian Federation (Sechenov University)
Russian Federation

Evgeny L. Nasonov

115522, Moscow, Kashirskoye Highway, 34A

119991, Moscow, Trubetskaya str., 8, building 2


Competing Interests:

нет



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Rybakova V.V., Avdeeva A.S., Dibrov D.A., Nasonov Е.L. Relationship of cytokine level dynamics with longterm results of early rheumatoid arthritis therapy. Rheumatology Science and Practice. 2022;60(1):72–79. (In Russ.) https://doi.org/10.47360/1995-4484-2022-72-79

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