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Научно-практическая ревматология

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Роль интерлейкина 1 в развитии заболеваний человека: фокус на анакинре (рецепторном антагонисте ИЛ-1)

https://doi.org/10.47360/1995-4484-2022-280-298

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Аннотация

По современным представлениям, иммуновоспалительные заболевания (ИВЗ) человека в зависимости от преобладающих механизмов иммунопатогенеза разделяются на две основные категории – аутоиммунные и аутовоспалительные.

В то же время в патогенезе большинства ИВЗ принимают участие как аутоиммунные, так и аутовоспалительные механизмы, сложное взаимодействие которых находит отражение в полиморфизме клинических проявлений, вариантов течения, исходов и эффективности терапии. Предполагается, что при ИВЗ гиперпродукция цитокинов семейства интерлейкина (ИЛ) 1, являющихся одним из ключевых регуляторов врожденного иммунитета, определяет «перекрест» между механизмами аутовоспаления и аутоиммунитета. В настоящее время в клинической практике для подавления патологических эффектов ИЛ-1 используется препарат анакинра, представляющий собой рекомбинантный негликозилированый аналог антагониста ИЛ-1 рецептора, блокирующий сигнализацию как ИЛ-1β, так и ИЛ-1α. Анализ результатов клинического применения анакинры свидететельствует о том, что лечение данным препаратом следует рассматривать как перспективное направление фармакотерапии системных аутовоспалительных заболеваний (САВЗ) и критических состояний у детей и взрослых, связанных с развитием гипервоспаления. Представлены основные направления программы клинических исследований анакинры, включающие: определение места препарата в реализации стратегии «Лечение до достижения цели» (Treat to Target) и персонификации терапии, в первую очередь у пациентов с «резистентным» (difficult-to-treat) субтипом ревматоидного артрита (РА) и коморбидной патологией, а также с тяжелыми формами микрокристаллических артритов; возможности применения анакинры для улучшения ранней диагностики САВЗ у детей и взрослых; создание Российского регистра пациентов с САВЗ, которым потенциально показано лечение анакинрой. 

Об авторах

Е. Л. Насонов
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»; ФГАОУ ВО «Первый Московский государственный медицинский университет имени И.М. Сеченова» Минздрава России (Сеченовский Университет)
Россия

115522, Москва, Каширское шоссе, 34а;
119991, Москва, ул. Трубецкая, 8, стр. 2



М. Ю. Самсонов
ФГАОУ ВО «Первый Московский государственный медицинский университет имени И.М. Сеченова» Минздрава России (Сеченовский Университет)
Россия

119991, Москва, ул. Трубецкая, 8, стр. 2



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Рецензия

Для цитирования:


Насонов Е.Л., Самсонов М.Ю. Роль интерлейкина 1 в развитии заболеваний человека: фокус на анакинре (рецепторном антагонисте ИЛ-1). Научно-практическая ревматология. 2022;60(3):280-298. https://doi.org/10.47360/1995-4484-2022-280-298

For citation:


Nasonov E.L., Samsonov M.Yu. The role of interleukin 1 in the development of human diseases: focus on Anakinra (IL-1 receptor antagonist). Rheumatology Science and Practice. 2022;60(3):280-298. (In Russ.) https://doi.org/10.47360/1995-4484-2022-280-298

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