Preview

Научно-практическая ревматология

Расширенный поиск

Роль интерлейкина 1 в развитии заболеваний человека: фокус на анакинре (рецепторном антагонисте ИЛ-1)

https://doi.org/10.47360/1995-4484-2022-280-298

Полный текст:

Аннотация

По современным представлениям, иммуновоспалительные заболевания (ИВЗ) человека в зависимости от преобладающих механизмов иммунопатогенеза разделяются на две основные категории – аутоиммунные и аутовоспалительные.

В то же время в патогенезе большинства ИВЗ принимают участие как аутоиммунные, так и аутовоспалительные механизмы, сложное взаимодействие которых находит отражение в полиморфизме клинических проявлений, вариантов течения, исходов и эффективности терапии. Предполагается, что при ИВЗ гиперпродукция цитокинов семейства интерлейкина (ИЛ) 1, являющихся одним из ключевых регуляторов врожденного иммунитета, определяет «перекрест» между механизмами аутовоспаления и аутоиммунитета. В настоящее время в клинической практике для подавления патологических эффектов ИЛ-1 используется препарат анакинра, представляющий собой рекомбинантный негликозилированый аналог антагониста ИЛ-1 рецептора, блокирующий сигнализацию как ИЛ-1β, так и ИЛ-1α. Анализ результатов клинического применения анакинры свидететельствует о том, что лечение данным препаратом следует рассматривать как перспективное направление фармакотерапии системных аутовоспалительных заболеваний (САВЗ) и критических состояний у детей и взрослых, связанных с развитием гипервоспаления. Представлены основные направления программы клинических исследований анакинры, включающие: определение места препарата в реализации стратегии «Лечение до достижения цели» (Treat to Target) и персонификации терапии, в первую очередь у пациентов с «резистентным» (difficult-to-treat) субтипом ревматоидного артрита (РА) и коморбидной патологией, а также с тяжелыми формами микрокристаллических артритов; возможности применения анакинры для улучшения ранней диагностики САВЗ у детей и взрослых; создание Российского регистра пациентов с САВЗ, которым потенциально показано лечение анакинрой. 

Об авторах

Е. Л. Насонов
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»; ФГАОУ ВО «Первый Московский государственный медицинский университет имени И.М. Сеченова» Минздрава России (Сеченовский Университет)
Россия

115522, Москва, Каширское шоссе, 34а;
119991, Москва, ул. Трубецкая, 8, стр. 2



М. Ю. Самсонов
ФГАОУ ВО «Первый Московский государственный медицинский университет имени И.М. Сеченова» Минздрава России (Сеченовский Университет)
Россия

119991, Москва, ул. Трубецкая, 8, стр. 2



Список литературы

1. McGonagle D, McDermott MF. A proposed classification of the immunological diseases. PLoS Med. 2006;3(8):e297. doi: 10.1371/journal.pmed.0030297

2. Szekanecz Z, McInnes IB, Schett G, Szamosi S, Benkő S, Szűcs G. Autoinflammation and autoimmunity across rheumatic and musculoskeletal diseases. Nat Rev Rheumatol. 2021;17(10):585-595. doi: 10.1038/s41584-021-00652-9

3. McGonagle D, Watad A, Savic S. Mechanistic immunological based classification of rheumatoid arthritis. Autoimmun Rev. 2018;17(11):1115-1123. doi: 10.1016/j.autrev.2018.06.001

4. Savic S, Caseley EA, McDermott MF. Moving towards a systemsbased classification of innate immune-mediated diseases. Nat Rev Rheumatol. 2020;16(4):222-237. doi: 10.1038/s41584-020-0377-5

5. Garlanda C, Dinarello CA, Mantovani A. The interleukin-1 family: Back to the future. Immunity. 2013;39(6):1003-1018. doi: 10.1016/j.immuni.2013.11.010

6. Dinarello CA. An expanding role for interleukin-1 blockade from gout to cancer. Mol Med. 2014;20(Suppl 1):S43-S58. doi: 10.2119/molmed.2014.00232

7. Насонов ЕЛ, Елисеев МС. Роль интерлейкина 1 в развитии заболеваний человека. Научно-практическая ревматология. 2016;54(1):60-77. doi: 10.14412/1995-4484-2016-60-77

8. Doria A, Zen M, Bettio S, Gatto M, Bassi N, Nalotto L, et al. Autoinflammation and autoimmunity: bridging the divide. Autoimmun Rev. 2012;12(1):22-30. doi: 10.1016/j.autrev.2012.07.018

9. Mantovani A, Dinarello CA, Molgora M, Garlanda C. Interleukin-1 and related cytokines in the regulation of inflammation and immunity. Immunity. 2019;50(4):778-795. doi: 10.1016/j.immuni.2019.03.012

10. Migliorini P, Italiani P, Pratesi F, Puxeddu I, Boraschi D. The IL-1 family cytokines and receptors in autoimmune diseases. Autoimmun Rev. 2020;19(9):102617. doi: 10.1016/j.autrev.2020.102617

11. Schett G, Dayer JM, Manger B. Interleukin-1 function and role in rheumatic disease. Nat Rev Rheumatol. 2016;12(1):14-24. doi: 10.1038/nrrheum.2016.166

12. Dinarello CA. The IL-1 family of cytokines and receptors in rheumatic diseases. Nat Rev Rheumatol. 2019;15(10):612-632. doi: 10.1038/s41584-019-0277-8

13. Betrains A, Staels F, Schrijvers R, Meyts I, Humblet-Baron S, De Langhe E, et al. Systemic autoinflammatory disease in adults. Autoimmun Rev. 2021;20(4):102774. doi: 10.1016/j.autrev.2021.102774

14. Staels F, Collignon T, Betrains A, Gerbaux M, Willemsen M, Humblet-Baron S, et al. Monogenic adult-onset inborn errors of immunity. Front Immunol. 2021;12:753978. doi: 10.3389/fimmu.2021.753978

15. Krainer J, Siebenhandl S, Weinhäusel A. Systemic autoinflammatory diseases. J Autoimmun. 2020;109:102421. doi: 10.1016/j.jaut.2020.102421

16. Nigrovic PA, Lee PY, Hoffman HM. Monogenic autoinflammatory disorders: Conceptual overview, phenotype, and clinical approach. J Allergy Clin Immunol. 2020;146(5):925-937. doi: 10.1016/j.jaci.2020.08.017

17. Rood JE, Behrens EM. Inherited autoinflammatory syndromes. Annu Rev Pathol. 2022;17:227-249. doi: 10.1146/annurev-pathmechdis-030121-041528

18. Di Donato G, d’Angelo DM, Breda L, Chiarelli F. Monogenic autoinflammatory diseases: State of the art and future perspectives. Int J Mol Sci. 2021;22(12):6360. doi: 10.3390/ijms22126360

19. Dinarello CA, Simon A, van der Meer JW. Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases. Nat Rev Drug Discov. 2012;11(8):633-652. doi: 10.1038/nrd3800

20. Malcova H, Milota T, Strizova Z, Cebecauerova D, Striz I, Sediva A, et al. Interleukin-1 blockade in polygenic autoinflammatory disorders: Where are we now? Front Pharmacol. 2021;11:619273. doi: 10.3389/fphar.2020.619273

21. Calabrese L, Fiocco Z, Satoh TK, Peris K, French LE. Therapeutic potential of targeting interleukin-1 family cytokines in chronic inflammatory skin diseases. Br J Dermatol. 2022;186(6):925-941. doi: 10.1111/bjd.20975

22. Bettiol A, Lopalco G, Emmi G, Cantarini L, Urban ML, Vitale A, et al. Unveiling the efficacy, safety, and tolerability of antiinterleukin-1 treatment in monogenic and multifactorial autoinflammatory diseases. Int J Mol Sci. 2019;20(8):1898. doi: 10.3390/ijms20081898

23. Cvetkovic RS, Keating G. Anakinra. BioDrugs. 2002;16(4): 303-311. doi: 10.2165/00063030-200216040-00005

24. Cavalli G, Dinarello CA. Anakinra therapy for non-cancer inflammatory diseases. Front Pharmacol. 2018;9:1157. doi: 10.3389/fphar.2018.01157

25. Stefania S, Colia R, Cinzia R, Corrado A, Cantatore FP. Off-label use of anti-IL-1 drugs in rheumatic diseases. Int J Immunopathol Pharmacol. 2021;35:20587384211006584. doi: 10.1177/20587384211006584

26. Maniscalco V, Abu-Rumeileh S, Mastrolia MV, Marrani E, Maccora I, Pagnini I, et al. The off-label use of anakinra in pediatric systemic autoinflammatory diseases. Ther Adv Musculoskelet Dis. 2020;12:1759720X20959575. doi: 10.1177/1759720X20959575

27. Hentgen V, Vinit C, Fayand A, Georgin-Lavialle S. The use of interleukine-1 inhibitors in familial mediterranean fever patients: A narrative review. Front Immunol. 2020;11:971. doi: 10.3389/fimmu.2020.00971

28. Rossi-Semerano L, Fautrel B, Wendling D, Hachulla E, Galeotti C, Semerano L, et al.; MAIL1 (Maladies Autoinflammatoires et Anti-IL-1) study Group on behalf of CRI (Club Rhumatisme et Inflammation). Tolerance and efficacy of off-label anti-interleukin-1 treatments in France: A nationwide survey. Orphanet J Rare Dis. 2015;10:19. doi: 10.1186/s13023-015-0228-7

29. Hentgen V, Koné-Paut I, Belot A, Galeotti C, Grateau G, Carbasse A, et al. Long-term follow-up and optimization of interleukin-1 inhibitors in the management of monogenic autoinflammatory diseases: Real-life data from the JIR cohort. Front Pharmacol. 2021;11:568865. doi: 10.3389/fphar.2020.568865

30. Ben-Zvi I, Kukuy O, Giat E, Pras E, Feld O, Kivity S, et al. Anakinra for colchicine-resistant familial Mediterranean fever: A randomized, double-blind, placebo-controlled trial. Arthritis Rheumatol. 2017;69(4):854-862. doi: 10.1002/art.39995

31. Yin X, Tian F, Wu B, Xu T. Interventions for reducing inflammation in familial Mediterranean fever. Cochrane Database Syst Rev. 2022;3(3):CD010893. doi: 10.1002/14651858.CD010893.pub4

32. Ozen S, Demirkaya E, Erer B, Livneh A, Ben-Chetrit E, Giancane G, et al. EULAR recommendations for the management of familial Mediterranean fever. Ann Rheum Dis. 2016;75(4):644-651. doi: 10.1136/annrheumdis-2015-208690

33. Gattorno M, Pelagatti MA, Meini A, Obici L, Barcellona R, Federici S, et al. Persistent efficacy of anakinra in patients with tumor necrosis factor receptor-associated periodic syndrome. Arthritis Rheum. 2008;58(5):1516-1520. doi: 10.1002/art.23475

34. Grimwood C, Despert V, Jeru I, Hentgen V. On-demand treatment with anakinra: A treatment option for selected TRAPS patients. Rheumatology (Oxford). 2015;54(9):1749-1751. doi: 10.1093/rheumatology/kev111

35. Rigante D, Ansuini V, Bertoni B, Pugliese AL, Avallone L, Federico G, et al. Treatment with anakinra in the hyperimmunoglobulinemia D/periodic fever syndrome. Rheumatol Int. 2006;27(1):97-100. doi: 10.1007/s00296-006-0164-x

36. Bodar EJ, Kuijk LM, Drenth JP, van der Meer JW, Simon A, Frenkel J. On-demand anakinra treatment is effective in mevalonate kinase deficiency. Ann Rheum Dis. 2011;70(12): 2155-2158. doi: 10.1136/ard.2011.149922

37. Galeotti C, Meinzer U, Quartier P, Rossi-Semerano L, BaderMeunier B, Pillet P, et al. Efficacy of interleukin-1-targeting drugs in mevalonate kinase deficiency. Rheumatology (Oxford). 2012;51(10):1855-1859. doi: 10.1093/rheumatology/kes097

38. Shendi HM, Walsh D, Edgar JD. Etanercept and anakinra can prolong febrile episodes in patients with hyperimmunoglobulin D and periodic fever syndrome. Rheumatol Int. 2012;32(1):249-251. doi: 10.1007/s00296-009-1322-8

39. Campanilho-Marques R, Brogan PA. Mevalonate kinase deficiency in two sisters with therapeutic response to anakinra: Case report and review of the literature. Clin Rheumatol. 2014;33(11):1681-1684. doi: 10.1007/s10067-014-2523-4

40. Vitale A, Obici L, Cattalini M, Lopalco G, Merlini G, Ricco N, et al. Biotechnological agents for patients with tumor necrosis factor receptor associated periodic syndrome-therapeutic outcome and predictors of response: Real-life data from the AIDA network. Front Med (Lausanne). 2021;8:668173. doi: 10.3389/fmed.2021.668173

41. Gaggiano C, Rigante D, Hernández-Rodríguez J, Vitale A, Tarsia M, Soriano A, et al. Anakinra and canakinumab for patients with R92Q-associated autoinflammatory syndrome: A multicenter observational study from the AIDA Network. Ther Adv Musculoskelet Dis. 2021;13:1759720X211037178. doi: 10.1177/1759720X211037178

42. Camprubí D, Mitjavila F, Arostegui JI, Corbella X. Efficacy of anakinra in an adult patient with recurrent pericarditis and cardiac tamponade as initial manifestations of tumor necrosis factor receptor-associated periodic syndrome due to the R92Q TNFRSF1A variant. Int J Rheum Dis. 2017;20(4):510-514. doi: 10.1111/1756-185X.13029

43. Hansmann S, Lainka E, Horneff G, Holzinger D, Rieber N, Jansson AF, et al. Consensus protocols for the diagnosis and management of the hereditary autoinflammatory syndromes CAPS, TRAPS and MKD/HIDS: A German PRO-KIND initiative. Pediatr Rheumatol Online J. 2020;18(1):17. doi: 10.1186/s12969-020-0409-3

44. Soriano A, Soriano M, Espinosa G, Manna R, Emmi G, Cantarini L, et al. Current therapeutic options for the main monogenic autoinflammatory diseases and PFAPA syndrome: Evidencebased approach and proposal of a practical guide. Front Immunol. 2020;11:865. doi: 10.3389/fimmu.2020.00865

45. ter Haar NM, Oswald M, Jeyaratnam J, Anton J, Barron KS, Brogan PA, et al. Recommendations for the management of autoinflammatory diseases. Ann Rheum Dis. 2015;74(9):1636-1644. doi: 10.1136/annrheumdis-2015-207546

46. Pardeo M, Pires Marafon D, Messia V, Garganese MC, De Benedetti F, Insalaco A. Anakinra in a cohort of children with chronic nonbacterial osteomyelitis. J Rheumatol. 2017;44(8): 1231-1238. doi: 10.3899/jrheum.160690

47. Dierselhuis MP, Frenkel J, Wulffraat NM, Boelens JJ. Anakinra for flares of pyogenic arthritis in PAPA syndrome. Rheumatology (Oxford). 2005;44(3):406-408. doi: 10.1093/rheumatology/keh479

48. Brenner M, Ruzicka T, Plewig G, Thomas P, Herzer P. Targeted treatment of pyoderma gangrenosum in PAPA (pyogenic arthritis, pyoderma gangrenosum and acne) syndrome with the recombinant human interleukin-1 receptor antagonist anakinra. Br J Dermatol. 2009;161(5):1199-1201. doi: 10.1111/j.1365-2133.2009.09404.x

49. Braun-Falco M, Kovnerystyy O, Lohse P, Ruzicka T. Pyoderma gangrenosum, acne, and suppurative hidradenitis (PASH) – A new autoinflammatory syndrome distinct from PAPA syndrome. J Am Acad Dermatol. 2012;66(3):409-415. doi: 10.1016/j.jaad.2010.12.025

50. Schellevis MA, Stoffels M, Hoppenreijs EP, Bodar E, Simon A, van der Meer JW. Variable expression and treatment of PAPA syndrome. Ann Rheum Dis. 2011;70(6):1168-1170. doi: 10.1136/ard.2009.126185

51. Huang J, Tsang LS, Shi W, Li J. Pyoderma gangrenosum, acne, and hidradenitis suppurativa syndrome: A case report and literature review. Front Med (Lausanne). 2022;9:856786. doi: 10.3389/fmed.2022.856786

52. Marzano AV, Ishak RS, Saibeni S, Crosti C, Meroni PL, Cugno M. Autoinflammatory skin disorders in inflammatory bowel diseases, pyoderma gangrenosum and Sweet’s syndrome: A comprehensive review and disease classification criteria. Clin Rev Allergy Immunol. 2013;45(2):202-210. doi: 10.1007/s12016-012-8351-x

53. Aksentijevich I, Masters SL, Ferguson PJ, Dancey P, Frenkel J, van Royen-Kerkhoff A, et al. An autoinflammatory disease with deficiency of the interleukin-1-receptor antagonist. N Engl J Med. 2009;360(23):2426-2437. doi: 10.1056/NEJMoa0807865

54. Sakran W, Shalev SA, Sakran W, Shalev SA, El-Shanti H, Uziel Y, et al. Chronic recurrent multifocal osteomyelitis and deficiency of interleukin-1-receptor antagonist. Pediatr Infect Dis J. 2013;32(1):94. doi: 10.1097/INF.0b013e3182700cc1

55. Aróstegui JI, Arnal C, Merino R, Modesto C, Antonia Carballo M, Moreno P, et al. NOD2 gene-associated pediatric granulomatous arthritis: clinical diversity, novel and recurrent mutations, and evidence of clinical improvement with interleukin-1 blockade in a Spanish cohort. Arthritis Rheum. 2007;56(11):3805-3813. doi: 10.1002/art.22966

56. Ruiz Gomez A, Couce ML, Garcia-Villoria J, Torres A, Baña Souto A, Yagüe J, et al. Clinical, genetic, and therapeutic diversity in 2 patients with severe mevalonate kinase deficiency. Pediatrics. 2012;129(2):e535-e539. doi: 10.1542/peds.2010-2192

57. Herlin T, Fiirgaard B, Bjerre M, Kerndrup G, Hasle H, Bing X, et al. Efficacy of anti-IL-1 treatment in Majeed syndrome. Ann Rheum Dis. 2013;72(3):410-413. doi: 10.1136/annrheumdis-2012-201818

58. Jéru I, Hentgen V, Normand S, Duquesnoy P, Cochet E, Delwail A, et al. Role of interleukin-1β in NLRP12-associated autoinflammatory disorders and resistance to anti-interleukin-1 therapy. Arthritis Rheum. 2011;63(7):2142-2148. doi: 10.1002/art.30378

59. Harrison SR, McGonagle D, Nizam S, Jarrett S, van der Hilst J, McDermott MF, et al. Anakinra as a diagnostic challenge and treatment option for systemic autoinflammatory disorders of undefined etiology. JCI Insight. 2016;1(6):e86336. doi: 10.1172/jci.insight.86336

60. Garg S, Wynne K, Omoyinmi E, Eleftheriou D, Brogan P. Efficacy and safety of anakinra for undifferentiated autoinflammatory diseases in children: A retrospective case review. Rheumatol Adv Pract. 2019;3(1):rkz004. doi: 10.1093/rap/rkz004

61. Subedi A, Schwartz D, Barron K, Kastner DL, Ombrello A. Interleukin-1 receptor antagonist is a potential treatment for undifferentiated autoinflammatory syndromes. Arthritis Rheumatol. 2017;69(Suppl 10). URL: https://acrabstracts.org/abstract/interleukin-1-receptor-antagonist-is-a-potential-treatment-for-undifferentiated-autoinflammatory-syndromes/ (Accessed: 30th March 2022).

62. Ilowite N, Porras O, Reiff A, Rudge S, Punaro M, Martin A, et al. Anakinra in the treatment of polyarticular-course juvenile rheumatoid arthritis: Safety and preliminary efficacy results of a randomized multicenter study. Clin Rheumatol. 2009;28(2):129-137. doi: 10.1007/s10067-008-0995-9

63. Quartier P, Allantaz F, Cimaz R, Pillet P, Messiaen C, Bardin C, et al. A multicentre, randomised, double-blind, placebo-controlled trial with the interleukin-1 receptor antagonist anakinra in patients with systemic-onset juvenile idiopathic arthritis (ANAJIS trial). Ann Rheum Dis. 2011;70(5):747-754. doi: 10.1136/ard.2010.134254

64. Pascual V, Allantaz F, Arce E, Punaro M, Banchereau J. Role of interleukin-1 (IL-1) in the pathogenesis of systemic onset juvenile idiopathic arthritis and clinical response to IL-1 blockade. J Exp Med. 2005;201(9):1479-1486. doi: 10.1084/jem.20050473

65. Gattorno M, Piccini A, Lasigliè D, Tassi S, Brisca G, Carta S, et al. The pattern of response to anti-interleukin-1 treatment distinguishes two subsets of patients with systemic-onset juvenile idiopathic arthritis. Arthritis Rheum. 2008;58(5):1505-1515. doi: 10.1002/art.23437

66. Lequerré T, Quartier P, Rosellini D, Alaoui F, De Bandt M, Mejjad O, et al.; Société Francophone pour la Rhumatologie et les Maladies Inflammatoires en Pédiatrie (SOFREMIP); Club Rhumatismes et Inflammation (CRI). Interleukin-1 receptor antagonist (anakinra) treatment in patients with systemic-onset juvenile idiopathic arthritis or adult onset Still disease: Preliminary experience in France. Ann Rheum Dis. 2008;67(3):302-308. doi: 10.1136/ard.2007.076034

67. Vastert SJ, de Jager W, Noordman BJ, Holzinger D, Kuis W, Prakken BJ, et al. Effectiveness of first-line treatment with recombinant interleukin-1 receptor antagonist in steroid-naive patients with new-onset systemic juvenile idiopathic arthritis: Results of a prospective cohort study. Arthritis Rheumatol. 2014;66(4): 1034-1043. doi: 10.1002/art.38296

68. Kearsley-Fleet L, Beresford MW, Davies R, De Cock D, Baildam E, Foster HE, et al. Short-term outcomes in patients with systemic juvenile idiopathic arthritis treated with either tocilizumab or anakinra. Rheumatology (Oxford). 2019;58(1):94-102. doi: 10.1093/rheumatology/key262

69. Ohlsson V, Baildam E, Foster H, Jandial S, Pain C, Strike H, et al. Anakinra treatment for systemic onset juvenile idiopathic arthritis (SOJIA). Rheumatology (Oxford). 2008;47(4):555-556. doi: 10.1093/rheumatology/ken030

70. Zeft A, Hollister R, LaFleur B, Sampath P, Soep J, McNally B, et al. Anakinra for systemic juvenile arthritis: the Rocky Mountain experience. J Clin Rheumatol. 2009;15(4):161-164. doi: 10.1097/RHU.0b013e3181a4f459

71. Nigrovic PA, Mannion M, Prince FH, Zeft A, Rabinovich CE, van Rossum MA, et al. Anakinra as first-line disease-modifying therapy in systemic juvenile idiopathic arthritis: report of forty-six patients from an international multicenter series. Arthritis Rheum. 2011;63(2):545-555. doi: 10.1002/art.30128

72. Pardeo M, Pires Marafon D, Insalaco A, Bracaglia C, Nicolai R, Messia V, et al. Anakinra in systemic juvenile idiopathic arthritis: A single-center experience. J Rheumatol. 2015;42(8):1523-1527. doi: 10.3899/jrheum.141567

73. Woerner A, Uettwiller F, Melki I, Mouy R, Wouters C, BaderMeunier B, et al. Biological treatment in systemic juvenile idiopathic arthritis: Achievement of inactive disease or clinical remission on a first, second or third biological agent. RMD Open. 2015;1(1):e000036. doi: 10.1136/rmdopen-2014-000036

74. Vitale A, Insalaco A, Sfriso P, Lopalco G, Emmi G, Cattalini M, et al. A snapshot on the on-label and off-label use of the interleukin-1 inhibitors in italy among rheumatologists and pediatric rheumatologists: A nationwide multi-center retrospective observational study. Front Pharmacol. 2016;7:380. doi: 10.3389/fphar.2016.00380

75. Saccomanno B, Tibaldi J, Minoia F, Bagnasco F, Pistorio A, Guariento A, et al. Predictors of effectiveness of anakinra in systemic juvenile idiopathic arthritis. J Rheumatol. 2019;46(4):416-421. doi: 10.3899/jrheum.180331

76. Ter Haar NM, van Dijkhuizen EHP, Swart JF, van RoyenKerkhof A, El Idrissi A, et al. Treatment to target using recombinant interleukin-1 receptor antagonist as first-line monotherapy in new-onset systemic juvenile idiopathic arthritis: Results from a five-year follow-up study. Arthritis Rheumatol. 2019;71(7):1163-1173. doi: 10.1002/art.40865

77. Giancane G, Papa R, Vastert S, Bagnasco F, Swart JF, Quartier P, et al.; Paediatric Rheumatology International Trials Organisation (PRINTO). Anakinra in patients with systemic juvenile idiopathic arthritis: Long-term safety from the pharmachild registry. J Rheumatol. 2022;49(4):398-407. doi: 10.3899/jrheum.210563

78. Vastert SJ, Jamilloux Y, Quartier P, Ohlman S, Osterling Koskinen L, Kullenberg T, et al. Anakinra in children and adults with Still’s disease. Rheumatology (Oxford). 2019;58(Suppl 6):vi9-vi22. doi: 10.1093/rheumatology/kez350

79. Nordström D, Knight A, Luukkainen R, van Vollenhoven R, Rantalaiho V, Kajalainen A, et al. Beneficial effect of interleukin 1 inhibition with anakinra in adult-onset Still’s disease. An open, randomized, multicenter study. J Rheumatol. 2012;39(10):2008-2011. doi: 10.3899/jrheum.111549

80. Giampietro C, Ridene M, Lequerre T, Costedoat Chalumeau N, Amoura Z, Sellam J, et al.; CRI (Club Rhumatismes et Inflammation). Anakinra in adult-onset Still’s disease: Long-term treatment in patients resistant to conventional therapy. Arthritis Care Res (Hoboken). 2013;65(5):822-826. doi: 10.1002/acr.21901

81. Vercruysse F, Barnetche T, Lazaro E, Shipley E, Lifermann F, Balageas A, et al. Adult-onset Still’s disease biological treatment strategy may depend on the phenotypic dichotomy. Arthritis Res Ther. 2019;21(1):53. doi: 10.1186/s13075-019-1838-6

82. Laskari K, Tzioufas AG, Moutsopoulos HM. Efficacy and longterm follow-up of IL-1R inhibitor anakinra in adults with Still’s disease: A case-series study. Arthritis Res Ther. 2011;13(3):R91. doi: 10.1186/ar3366

83. Cavalli G, Franchini S, Aiello P, Guglielmi B, Berti A, Campochiaro C, et al. Efficacy and safety of biological agents in adult-onset Still’s disease. Scand J Rheumatol. 2015;44(4): 309-314. doi: 10.3109/03009742.2014.992949

84. Colafrancesco S, Priori R, Valesini G, Argolini L, Baldissera E, Bartoloni E, et al. Response to interleukin-1 inhibitors in 140 Italian patients with adult-onset Still’s disease: A multicentre retrospective observational study. Front Pharmacol. 2017;8:369. doi: 10.3389/fphar.2017.00369

85. Dall’Ara F, Frassi M, Tincani A, Airò P. A retrospective study of patients with adult-onset Still’s disease: Is pericarditis a possible predictor for biological disease-modifying anti-rheumatic drugs need? Clin Rheumatol. 2016;35(8):2117-2123. doi: 10.1007/s10067-015-3164-y

86. Gerfaud-Valentin M, Maucort-Boulch D, Hot A, Iwaz J, Ninet J, Durieu I, et al. Adult-onset Still disease: Manifestations, treatment, outcome, and prognostic factors in 57 patients. Medicine (Baltimore). 2014;93(2):91-99. doi: 10.1097/MD.0000000000000021

87. Iliou C, Papagoras C, Tsifetaki N, Voulgari PV, Drosos AA. Adultonset Still’s disease: Clinical, serological and therapeutic considerations. Clin Exp Rheumatol. 2013;31(1):47-52.

88. Lequerré T, Quartier P, Rosellini D, Alaoui F, De Bandt M, Mejjad O, et al. Société Francophone pour la Rhumatologie et les Maladies Inflammatoires en Pédiatrie (SOFREMIP); Club Rhumatismes et Inflammation (CRI). Interleukin-1 receptor antagonist (anakinra) treatment in patients with systemic-onset juvenile idiopathic arthritis or adult onset Still disease: Preliminary experience in France. Ann Rheum Dis. 2008;67(3):302-308. doi: 10.1136/ard.2007.076034

89. Naumann L, Feist E, Natusch A, Langen S, Krause A, Buttgereit F, et al. IL1-receptor antagonist anakinra provides longlasting efficacy in the treatment of refractory adult-onset Still’s disease. Ann Rheum Dis. 2010;69(2):466-467. doi: 10.1136/ard.2009.108068

90. Sfriso P, Priori R, Valesini G, Rossi S, Montecucco CM, D’Ascanio A, et al. Adult-onset Still’s disease: An Italian multicentre retrospective observational study of manifestations and treatments in 245 patients. Clin Rheumatol. 2016;35(7):1683-1689. doi: 10.1007/s10067-016-3308-8

91. Ortiz-Sanjuán F, Blanco R, Riancho-Zarrabeitia L, Castañeda S, Olivé A, Riveros A, et al. Efficacy of anakinra in refractory adultonset Still’s disease: multicenter study of 41 patients and literature review. Medicine (Baltimore). 2015;94(39):e1554. doi: 10.1097/MD.0000000000001554

92. Vitale A, Cavalli G, Colafrancesco S, Priori R, Valesini G, Argolini LM, et al. Long-term retention rate of anakinra in adult onset Still’s disease and predictive factors for treatment response. Front Pharmacol. 2019;10:296. doi: 10.3389/fphar.2019.00296

93. Campochiaro C, Farina N, Tomelleri A, De Luca G, Baldissera E, Cavalli G, et al. Drug retention rates of biological agents in adult onset Still’s disease. Semin Arthritis Rheum. 2021;51(1):1-6. doi: 10.1016/j.semarthrit.2020.09.014

94. Nordström D, Knight A, Luukkainen R, van Vollenhoven R, Rantalaiho V, Kajalainen A, Brun JG, et al. Beneficial effect of interleukin 1 inhibition with anakinra in adult-onset Still’s disease. An open, randomized, multicenter study. J Rheumatol. 2012;39(10):2008-2011. doi: 10.3899/jrheum.111549

95. Giacomelli R, Sota J, Ruscitti P, Campochiaro C, Colafrancesco S, Dagna L, et al. The treatment of adult-onset Still’s disease with anakinra, a recombinant human IL-1 receptor antagonist: A systematic review of literature. Clin Exp Rheumatol. 2021;39(1):187-195.

96. Kedor C, Tomaras S, Baeumer D, Feist E. Update on the therapy of adult-onset Still’s disease with a focus on IL-1-inhibition: A systematic review. Ther Adv Musculoskelet Dis. 2021;13:1759720X211059598. doi: 10.1177/1759720X211059598

97. Ruscitti P, Ursini F, Sota J, De Giorgio R, Cantarini L, Giacomelli R. The reduction of concomitant glucocorticoids dosage following treatment with IL-1 receptor antagonist in adult onset Still’s disease. A systematic review and meta-analysis of observational studies. Ther Adv Musculoskelet Dis. 2020;12:1759720X20933133. doi: 10.1177/1759720X20933133

98. Janssen CA, Oude Voshaar MAH, Vonkeman HE, Jansen TLTA, Janssen M, Kok MR, et al. Anakinra for the treatment of acute gout flares: A randomized, double-blind, placebo-controlled, active-comparator, non-inferiority trial. Rheumatology (Oxford). 2019 Jan 2. doi: 10.1093/rheumatology/key402

99. Saag KG, Khanna PP, Keenan RT, Ohlman S, Osterling Koskinen L, Sparve E, et al. A randomized, phase II study evaluating the efficacy and safety of anakinra in the treatment of gout flares. Arthritis Rheumatol. 2021;73(8):1533-1542. doi: 10.1002/art.41699

100. Ottaviani S, Moltó A, Ea HK, Neveu S, Gill G, Brunier L, et al. Efficacy of anakinra in gouty arthritis: A retrospective study of 40 cases. Arthritis Res Ther. 2013;15(5):R123. doi: 10.1186/ar4303

101. Ghosh P, Cho M, Rawat G, Simkin PA, Gardner GC. Treatment of acute gouty arthritis in complex hospitalized patients with anakinra. Arthritis Care Res (Hoboken). 2013;65(8):1381-1384. doi: 10.1002/acr.21989

102. Thueringer JT, Doll NK, Gertner E. Anakinra for the treatment of acute severe gout in critically ill patients. Semin Arthritis Rheum. 2015;45(1):81-85. doi: 10.1016/j.semarthrit.2015.02.006

103. Loustau C, Rosine N, Forien M, Ottaviani S, Juge PA, Lioté F, et al. Effectiveness and safety of anakinra in gout patients with stage 4–5 chronic kidney disease or kidney transplantation: A multicentre, retrospective study. Joint Bone Spine. 2018;85(6):755-760. doi: 10.1016/j.jbspin.2018.03.015

104. Aouba A, Deshayes S, Frenzel L, Decottignies A, Pressiat C, Bienvenu B, et al. Efficacy of anakinra for various types of crystal-induced arthritis in complex hospitalized patients: A case series and review of the literature. Mediators Inflamm. 2015;2015:792173. doi: 10.1155/2015/792173

105. Saad Shaukat MH, Shabbir MA, Singh S, Torosoff M, PeredoWende R. Anakinra for colchicine-intolerant/colchicine-resistant acute gout flare precipitated by decompensated heart failure. Ir J Med Sci. 2021;190(1):129-131. doi: 10.1007/s11845-020-02322-3

106. Hassantoufighi A, Alejandro P, Collins CE, Constantinescu F, Bhargava J. Efficacy and safety of anakinra in congestive heart failure patients, including LVAD, with acute gouty arthritis: A retrospective study of 36 patients at an academic medical center. Arthritis Rheumatol. 2018;70(Suppl 10). URL: https://acrabstracts.org/abstract/efficacy-and-safety-of-anakinra-in-congestive-heart-failure-patients-including-lvad-with-acute-goutyarthritis-a-retrospective-study-of-36-patients-at-an-academicmedical-center (Accessed 30th March 2022).

107. Sharma E, Pedersen B, Terkeltaub R. Patients prescribed anakinra for acute gout have baseline increased burden of hyperuricemia, tophi, and comorbidities, and ultimate all-cause mortality. Clin Med Insights Arthritis Musculoskelet Disord. 2019;12:1179544119890853. doi: 10.1177/1179544119890853

108. Jeria Navarro S, Park H, Pou MA, Calvo-Aranda E, DiazTorne C. AB0643 Il-1 blockage with anakinra in gout patients. Scoping review of the published literature. Ann Rheum Dis. 2021;80:1354-1355.

109. Desmarais J, Chu CQ. Utility of anakinra in acute crystalline diseases: A retrospective study comparing a university hospital with a veterans affairs medical center. J Rheumatol. 2019;46(7):748-750. doi: 10.3899/jrheum.180393

110. Moltó A, Ea HK, Richette P, Bardin T, Lioté F. Efficacy of anakinra for refractory acute calcium pyrophosphate crystal arthritis. Joint Bone Spine. 2012;79(6):621-623. doi: 10.1016/j.jbspin.2012.01.010

111. Ottaviani S, Brunier L, Sibilia J, Maurier F, Ardizzone M, Wendling D, et al. Efficacy of anakinra in calcium pyrophosphate crystal-induced arthritis: A report of 16 cases and review of the literature. Joint Bone Spine. 2013;80(2):178-182. doi: 10.1016/j.jbspin.2012.07.018

112. Thomas M, Forien M, Palazzo E, Dieudé P, Ottaviani S. Efficacy and tolerance of anakinra in acute calcium pyrophosphate crystal arthritis: A retrospective study of 33 cases. Clin Rheumatol. 2019;38(2):425-430. doi: 10.1007/s10067-018-4272-2

113. Doaré E, Robin F, Racapé H, Le Mélédo G, Orione C, Guggenbuhl P, et al. Features and outcomes of microcrystalline arthritis treated by biologics: A retrospective study. Rheumatol Ther. 2021;8(3):1241-1253. doi: 10.1007/s40744-021-00335-7

114. Liew JW, Gardner GC. Use of anakinra in hospitalized patients with crystal-associated arthritis. J Rheumatol. 2019;46(10):1345-1349. doi: 10.3899/jrheum.181018

115. Cipolletta E, Di Matteo A, Scanu A, Isidori M, Di Battista J, Punzi L, et al. Biologics in the treatment of calcium pyrophosphate deposition disease: A systematic literature review. Clin Exp Rheumatol. 2020;38(5):1001-1007.

116. Dumusc A, Pazar Maldonado B, Benaim C, Zufferey P, AubryRozier B, So A. Anakinra compared to prednisone in the treatment of acute CPPD crystal arthritis: A randomized controlled doubleblinded pilot study. Joint Bone Spine. 2021;88(2):105088. doi: 10.1016/j.jbspin.2020.105088

117. Zufferey P, So A. A pilot study of IL-1 inhibition in acute calcific periarthritis of the shoulder. Ann Rheum Dis. 2013;72(3):465-467. doi: 10.1136/annrheumdis-2012-202380

118. Zufferey P, Valcov R, Thomas M, Dumusc A, Forien M, So A, et al. Efficacy of anakinra in acute hydroxyapatite calcificationinduced joint pain: A retrospective study of 23 cases. Joint Bone Spine. 2019;86(1):83-88. doi: 10.1016/j.jbspin.2018.05.008

119. Tan AL, Marzo-Ortega H, O’Connor P, Fraser A, Emery P, McGonagle D. Efficacy of anakinra in active ankylosing spondylitis: A clinical and magnetic resonance imaging study. Ann Rheum Dis. 2004;63(9):1041-1045. doi: 10.1136/ard.2004.020800

120. Jung N, Hellmann M, Hoheisel R, Lehmann C, Haase I, Perniok A, et al. An open-label pilot study of the efficacy and safety of anakinra in patients with psoriatic arthritis refractory to or intolerant of methotrexate (MTX). Clin Rheumatol. 2010;29(10):1169-1173. doi: 10.1007/s10067-010-1504-5

121. Chevalier X, Goupille P, Beaulieu AD, Burch FX, Bensen WG, Conrozier T, et al. Intraarticular injection of anakinra in osteoarthritis of the knee: A multicenter, randomized, double-blind, placebo-controlled study. Arthritis Rheum. 2009;61(3):344-352. doi: 10.1002/art.24096

122. Bacconnier L, Jorgensen C, Fabre S. Erosive osteoarthritis of the hand: clinical experience with anakinra. Ann Rheum Dis. 2009;68(6):1078-1079. doi: 10.1136/ard.2008.094284

123. Varan O, Babaoglu H, Atas N, Satis H, Salman RB, Tufan A, et al. Response to anakinra in 3 patients with erosive osteoarthritis. J Clin Rheumatol. 2021;27(2):e52-e53. doi: 10.1097/RHU.0000000000000861

124. Meng F, Li H, Feng H, Long H, Yang Z, Li J, et al. Efficacy and safety of biologic agents for the treatment of osteoarthritis: A meta-analysis of randomized placebo-controlled trials. Ther Adv Musculoskelet Dis. 2022;14:1759720X221080377. doi: 10.1177/1759720X221080377

125. Schuster C, Kränke B, Aberer E, Arbab E, Sturm G, Aberer W. Schnitzler syndrome: Response to anakinra in two cases and a review of the literature. Int J Dermatol. 2009;48(11): 1190-1194. doi: 10.1111/j.1365-4632.2009.04151.x

126. Vandenhende MA, Bentaberry F, Morlat P, Bonnet F. Anakinra: An effective treatment in the Schnitzler syndrome. Joint Bone Spine. 2011;78(6):636-637. doi: 10.1016/j.jbspin.2011.03.021

127. Sönnichsen A, Saulite I, Mangana J, Kerl K, Mehra T, Desislava I, et al. Interleukin-1 receptor antagonist (anakinra) for Schnitzler syndrome. J Dermatolog Treat. 2016;27(5):436-438. doi: 10.3109/09546634.2015.1136048

128. Gouveia AI, Micaelo M, Pierdomenico F, Freitas JP. Schnitzler syndrome: A dramatic response to anakinra. Dermatol Ther (Heidelb). 2016;6(2):299-302. doi: 10.1007/s13555-016-0108-7

129. Koch A, Tchernev G, Chokoeva AA, Lotti T, Wollina U. Schnitzler syndrome responding to interleukin-1 antagonist anakinra. J Biol Regul Homeost Agents. 2015;29(Suppl 1):19-21.

130. Gran JT, Midtvedt Ø, Haug S, Aukrust P. Treatment of Schnitzler’s syndrome with anakinra: Report of three cases and review of the literature. Scand J Rheumatol. 2011;40(1):74-79. doi: 10.3109/03009742.2010.493894

131. Crisafulli F, Vitale A, Airò P, Grigis M, Gaggiano C, Dagna L, et al. Retention rate of IL-1 inhibitors in Schnitzler’s syndrome. Clin Exp Rheumatol. 2022 Jan 12. doi: 10.55563/clinexprheumatol/14hu2k

132. Néel A, Henry B, Barbarot S, Masseau A, Perrin F, Bernier C, et al. Long-term effectiveness and safety of interleukin-1 receptor antagonist (anakinra) in Schnitzler’s syndrome: A French multicenter study. Autoimmun Rev. 2014;13(10):1035-1041. doi: 10.1016/j.autrev.2014.08.031

133. Bixio R, Rossini M, Giollo A. Efficacy of interleukin-1 blockade in Schnitzler’s syndrome without detectable monoclonal gammopathy: A case-based review. Clin Rheumatol. 2021;40(7):2973-2977. doi: 10.1007/s10067-020-05501-w

134. Besada E, Nossent H. Dramatic response to IL1-RA treatment in longstanding multidrug resistant Schnitzler’s syndrome: A case report and literature review. Clin Rheumatol. 2010;29(5):567-571. doi: 10.1007/s10067-010-1375-9

135. Botsios C, Sfriso P, Furlan A, Punzi L, Dinarello CA. Resistant Behçet disease responsive to anakinra. Ann Intern Med. 2008; 149(4):284-286. doi: 10.7326/0003-4819-149-4-200808190-00018

136. Grayson PC, Yazici Y, Merideth M, Sen HN, Davis M, Novakovich E, et al. Treatment of mucocutaneous manifestations in Behçet’s disease with anakinra: A pilot open-label study. Arthritis Res Ther. 2017;19(1):69. doi: 10.1186/s13075-017-1222-3

137. Fabiani C, Vitale A, Rigante D, Emmi G, Lopalco G, Di Scala G, et al. The presence of uveitis is associated with a sustained response to the interleukin (IL)-1 inhibitors anakinra and canakinumab in Behçet’s disease. Ocul Immunol Inflamm. 2020;28(2):298-304. doi: 10.1080/09273948.2018.1511810

138. Fabiani C, Vitale A, Emmi G, Lopalco G, Vannozzi L, Guerriero S, et al. Interleukin (IL)-1 inhibition with anakinra and canakinumab in Behçet’s disease-related uveitis: A multicenter retrospective observational study. Clin Rheumatol. 2017;36(1):191-197. doi: 10.1007/s10067-016-3506-4

139. Cantarini L, Vitale A, Scalini P, Dinarello CA, Rigante D, Franceschini R, et al. Anakinra treatment in drug-resistant Behcet’s disease: A case series. Clin Rheumatol. 2015;34(7): 1293-1301. doi: 10.1007/s10067-013-2443-8

140. Emmi G, Silvestri E, Squatrito D, Vitale A, Bacherini D, Vannozzi L, et al. Long-term efficacy and safety of anakinra in a patient with Behçet’s disease and concomitant tuberculosis infection. Int J Dermatol. 2017;56(2):218-220. doi: 10.1111/ijd.13337

141. Bettiol A, Silvestri E, Di Scala G, Amedei A, Becatti M, Fiorillo C, et al. The right place of interleukin-1 inhibitors in the treatment of Behçet’s syndrome: A systematic review. Rheumatol Int. 2019;39(6):971-990. doi: 10.1007/s00296-019-04259-y

142. Vitale A, Rigante D, Caso F, Franceschini R, Cantarini L. Interleukin-1 blockade in neuro-Behçet’s disease: A case-based reflection. Int J Rheum Dis. 2017;20(8):1046-1049. doi: 10.1111/1756-185X.12680

143. Cantarini L, Lopalco G, Caso F, Costa L, Iannone F, Lapadula G, et al. Effectiveness and tuberculosis-related safety profile of interleukin-1 blocking agents in the management of Behçet’s disease. Autoimmun Rev. 2015;14(1):1-9. doi: 10.1016/j.autrev.2014.08.008

144. Botsios C, Sfriso P, Punzi L, Todesco S. Non-complementaemic urticarial vasculitis: Successful treatment with the IL-1 receptor antagonist, anakinra. Scand J Rheumatol. 2007;36(3):236-237. doi: 10.1080/03009740600938647

145. Delluc A, Limal N, Puéchal X, Francès C, Piette JC, Cacoub P. Efficacy of anakinra, an IL1 receptor antagonist, in refractory Sweet syndrome. Ann Rheum Dis. 2008;67(2):278-279. doi: 10.1136/ard.2006.068254

146. Kluger N, Gil-Bistes D, Guillot B, Bessis D. Efficacy of antiinterleukin-1 receptor antagonist anakinra (Kineret®) in a case of refractory Sweet’s syndrome. Dermatology. 2011;222(2):123-127. doi: 10.1159/000326112

147. Shahid Z, Kalayanamitra R, Patel R, Groff A, Jain R. Refractory Sweet syndrome treated with anakinra. Cureus. 2019;11(4):e4536. doi: 10.7759/cureus.4536

148. Lipsker D, Perrigouard C, Foubert A, Cribier B. Anakinra for difficult-to-treat neutrophilic panniculitis: IL-1 blockade as a promising treatment option for neutrophil-mediated inflammatory skin disease. Dermatology. 2010;220(3):264-267. doi: 10.1159/000280436

149. Aubert O, Aouba A, Deshayes S, Georgin-Lavialle S, Rieu P, Hermine O. Favorable radiological outcome of skeletal Erdheim – Chester disease involvement with anakinra. Joint Bone Spine. 2013;80(2):206-207. doi: 10.1016/j.jbspin.2012.07.005

150. Killu AM, Liang JJ, Jaffe AS. Erdheim – Chester disease with cardiac involvement successfully treated with anakinra. Int J Cardiol. 2013;167(5):e115-e117. doi: 10.1016/j.ijcard.2013.04.057

151. Courcoul A, Vignot E, Chapurlat R. Successful treatment of Erdheim – Chester disease by interleukin-1 receptor antagonist protein. Joint Bone Spine. 2014;81(2):175-177. doi: 10.1016/j.jbspin.2013.06.013

152. Darstein F, Kirschey S, Heckl S, Rahman F, Schwarting A, Schuchmann M, et al. Successful treatment of Erdheim – Chester disease with combination of interleukin-1-targeting drugs and high-dose glucocorticoids. Intern Med J. 2014;44(1):90-92. doi: 10.1111/imj.12329

153. Cohen PR, Kurzrock R. Anakinra-responsive lichen planus in a woman with Erdheim – Chester disease: A therapeutic enigma. Dermatol Online J. 2014;20(1):21241.

154. Tomelleri A, Cavalli G, De Luca G, Campochiaro C, D’Aliberti T, Tresoldi M, Dagna L. Treating heart inflammation with interleukin-1 blockade in a case of Erdheim – Chester disease. Front Immunol. 2018;9:1233. doi: 10.3389/fimmu.2018.01233

155. Cohen-Aubart F, Maksud P, Saadoun D, Drier A, Charlotte F, Cluzel P, et al. Variability in the efficacy of the IL1 receptor antagonist anakinra for treating Erdheim – Chester disease. Blood. 2016;127(11):1509-1512. doi: 10.1182/blood-2015-09-672667

156. Diamond EL, Abdel-Wahab O, Durham BH, Dogan A, Ozkaya N, Brody L, et al. Anakinra as efficacious therapy for 2 cases of intracranial Erdheim – Chester disease. Blood. 2016;128(14):1896-1898. doi: 10.1182/blood-2016-06-725143

157. Tomelleri A, Cavalli G, De Luca G, Campochiaro C, D’Aliberti T, Tresoldi M, et al. Treating heart inflammation with interleukin-1 blockade in a case of Erdheim – Chester disease. Front Immunol. 2018;9:1233. doi: 10.3389/fimmu.2018.01233

158. Wendling D, Prati C, Aubin F. Anakinra treatment of SAPHO syndrome: Short-term results of an open study. Ann Rheum Dis. 2012;71(6):1098-1100. doi: 10.1136/annrheumdis-2011-200743

159. Cantarini L, Vitale A, Galeazzi M, Frediani B. A case of resistant adult-onset periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) syndrome responsive to anakinra. Clin Exp Rheumatol. 2012;30(4):593.

160. Leslie KS, Tripathi SV, Nguyen TV, Pauli M, Rosenblum MD. An open-label study of anakinra for the treatment of moderate to severe hidradenitis suppurativa. J Am Acad Dermatol. 2014;70(2):243-251. doi: 10.1016/j.jaad.2013.09.044

161. Tzanetakou V, Kanni T, Giatrakou S, Katoulis A, Papadavid E, Netea MG, et al. Safety and efficacy of anakinra in severe hidradenitis suppurativa: A randomized clinical trial. JAMA Dermatol. 2016;152(1):52-59. doi: 10.1001/jamadermatol.2015.3903

162. Zarchi K, Dufour DN, Jemec GB. Successful treatment of severe hidradenitis suppurativa with anakinra. JAMA Dermatol. 2013;149(10):1192-1194. doi: 10.1001/jamadermatol.2013.5377

163. André R, Marescassier H, Gabay C, Pittet B, Laffitte E. Longterm therapy with anakinra in hidradenitis suppurativa in three patients. Int J Dermatol. 2019;58(11):e208-e209. doi: 10.1111/ijd.14596

164. van der Zee HH, Prens EP. Failure of anti-interleukin-1 therapy in severe hidradenitis suppurativa: A case report. Dermatology. 2013;226(2):97-100. doi: 10.1159/000343221

165. Russo V, Alikhan A. Failure of anakinra in a case of severe hidradenitis suppurativa. J Drugs Dermatol. 2016;15(6):772-774.

166. Galeotti C, Tran TA, Franchi-Abella S, Fabre M, Pariente D, Koné-Paut I. IL-1RA agonist (anakinra) in the treatment of multifocal castleman disease: Case report. J Pediatr Hematol Oncol. 2008;30(12):920-924. doi: 10.1097/MPH.0b013e31818ab31f

167. El-Osta H, Janku F, Kurzrock R. Successful treatment of Castleman’s disease with interleukin-1 receptor antagonist (Anakinra). Mol Cancer Ther. 2010;9(6):1485-1488. doi: 10.1158/1535-7163.MCT-10-0156

168. Soudet S, Fajgenbaum D, Delattre C, Forestier A, Hachulla E, Hatron PY, et al. Schnitzler syndrome co-occurring with idiopathic multicentric Castleman disease that responds to antiIL-1 therapy: A case report and clue to pathophysiology. Curr Res Transl Med. 2018;66(3):83-86. doi: 10.1016/j.retram.2018.06.001

169. O’Connor C, Gallagher C, Hollywood A, Paul L, O’Connell M. Anakinra for recalcitrant pyoderma gangrenosum. Clin Exp Dermatol. 2021;46(8):1558-1560. doi: 10.1111/ced.14809

170. Bresnihan B, Alvaro-Gracia JM, Cobby M, Doherty M, Domljan Z, Emery P, et al. Treatment of rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist. Arthritis Rheum. 1998;41(12):2196-2204. doi: 10.1002/1529-0131(199812)41:12<2196::AID-ART15>3.0.CO;2-2

171. Cohen S, Hurd E, Cush J, Schiff M, Weinblatt ME, Moreland LW, et al. Treatment of rheumatoid arthritis with anakinra, a recombinant human interleukin-1 receptor antagonist, in combination with methotrexate: Results of a twenty-four-week, multicenter, randomized, double-blind, placebo-controlled trial. Arthritis Rheum. 2002;46(3):614-624. doi: 10.1002/art.10141

172. Fleischmann RM, Schechtman J, Bennett R, Handel ML, Burmester GR, Tesser J, et al. Anakinra, a recombinant human interleukin-1 receptor antagonist (r-metHuIL-1ra), in patients with rheumatoid arthritis: A large, international, multicenter, placebo-controlled trial. Arthritis Rheum. 2003;48(4):927-934. doi: 10.1002/art.10870

173. Nuki G, Bresnihan B, Bear MB, McCabe D; European Group of Clinical Investigators. Long-term safety and maintenance of clinical improvement following treatment with anakinra (recombinant human interleukin-1 receptor antagonist) in patients with rheumatoid arthritis: Extension phase of a randomized, double-blind, placebo-controlled trial. Arthritis Rheum. 2002;46(11):2838-2846. doi: 10.1002/art.10578

174. Cohen SB, Moreland LW, Cush JJ, Greenwald MW, Block S, Shergy WJ, et al.; 990145 Study Group. A multicentre, double blind, randomised, placebo controlled trial of anakinra (Kineret), a recombinant interleukin 1 receptor antagonist, in patients with rheumatoid arthritis treated with background methotrexate. Ann Rheum Dis. 2004;63(9):1062-1068. doi: 10.1136/ard.2003.016014

175. Schiff MH, DiVittorio G, Tesser J, Fleischmann R, Schechtman J, Hartman S, et al. The safety of anakinra in highrisk patients with active rheumatoid arthritis: six-month observations of patients with comorbid conditions. Arthritis Rheum. 2004;50(6):1752-1760. doi: 10.1002/art.20277

176. Fleischmann RM, Tesser J, Schiff MH, Schechtman J, Burmester GR, Bennett R, et al. Safety of extended treatment with anakinra in patients with rheumatoid arthritis. Ann Rheum Dis. 2006;65(8):1006-1012. doi: 10.1136/ard.2005.048371

177. Clark W, Jobanputra P, Barton P, Burls A. The clinical and costeffectiveness of anakinra for the treatment of rheumatoid arthritis in adults: a systematic review and economic analysis. Health Technol Assess. 2004;8(18):iii-105. doi: 10.3310/hta8180

178. Mertens M, Singh JA. Anakinra for rheumatoid arthritis: A systematic review. J Rheumatol. 2009;36(6):1118-1125. doi: 10.3899/jrheum.090074

179. Bedaiwi MK, Almaghlouth I, Omair MA. Effectiveness and adverse effects of anakinra in treatment of rheumatoid arthritis: A systematic review. Eur Rev Med Pharmacol Sci. 2021;25(24):7833-7839. doi: 10.26355/eurrev_202112_27630

180. Nam JL, Ramiro S, Gaujoux-Viala C, Takase K, LeonGarcia M, Emery P, et al. Efficacy of biological disease-modifying antirheumatic drugs: A systematic literature review informing the 2013 update of the EULAR recommendations for the management of rheumatoid arthritis. Ann Rheum Dis. 2014;73(3):516-528. doi: 10.1136/annrheumdis-2013-204577

181. Singh JA, Christensen R, Wells GA, Suarez-Almazor ME, Buchbinder R, Lopez-Olivo MA, et al. Biologics for rheumatoid arthritis: an overview of Cochrane reviews. Cochrane Database Syst Rev. 2009;(4):CD007848. doi: 10.1002/14651858.CD007848.pub2

182. Nikfar S, Saiyarsarai P, Tigabu BM, Abdollahi M. Efficacy and safety of interleukin-1 antagonists in rheumatoid arthritis: A systematic review and meta-analysis. Rheumatol Int. 2018;38(8):1363-1383. doi: 10.1007/s00296-018-4041-1

183. Ruscitti P, Masedu F, Alvaro S, Airò P, Battafarano N, Cantarini L, et al. Anti-interleukin-1 treatment in patients with rheumatoid arthritis and type 2 diabetes (TRACK): A multicentre, open-label, randomised controlled trial. PLoS Med. 2019;16(9):e1002901. doi: 10.1371/journal.pmed.1002901

184. Ruscitti P, Berardicurti O, Cipriani P, Giacomelli R; TRACK study group. Benefits of anakinra versus TNF inhibitors in rheumatoid arthritis and type 2 diabetes: Long-term findings from participants furtherly followed-up in the TRACK study, a multicentre, open-label, randomised, controlled trial. Clin Exp Rheumatol. 2021;39(2):403-406.

185. Ostendorf B, Iking-Konert C, Kurz K, Jung G, Sander O, Schneider M. Preliminary results of safety and efficacy of the interleukin 1 receptor antagonist anakinra in patients with severe lupus arthritis. Ann Rheum Dis. 2005;64(4):630-633. doi: 10.1136/ard.2004.025858

186. Norheim KB, Harboe E, Gøransson LG, Omdal R. Interleukin-1 inhibition and fatigue in primary Sjögren’s syndrome – A double blind, randomised clinical trial. PLoS One. 2012;7(1):e30123. doi: 10.1371/journal.pone.0030123

187. Ly KH, Stirnemann J, Liozon E, Michel M, Fain O, Fauchais AL. Interleukin-1 blockade in refractory giant cell arteritis. Joint Bone Spine. 2014;81(1):76-78. doi: 10.1016/j.jbspin.2013.06.004

188. Brucato A, Imazio M, Gattorno M, Lazaros G, Maestroni S, Carraro M, et al. Effect of anakinra on recurrent pericarditis among patients with colchicine resistance and corticosteroid dependence: The AIRTRIP randomized clinical trial. JAMA. 2016;316(18):1906-1912. doi: 10.1001/jama.2016.15826

189. Imazio M, Andreis A, De Ferrari GM, Cremer PC, Mardigyan V, Maestroni S, et al. Anakinra for corticosteroid-dependent and colchicine-resistant pericarditis: The IRAP (International Registry of Anakinra for Pericarditis) study. Eur J Prev Cardiol. 2020;27(9):956-964. doi: 10.1177/2047487319879534

190. Picco P, Brisca G, Traverso F, Loy A, Gattorno M, Martini A. Successful treatment of idiopathic recurrent pericarditis in children with interleukin-1beta receptor antagonist (anakinra): An unrecognized autoinflammatory disease? Arthritis Rheum. 2009;60(1):264-268. doi: 10.1002/art.24174

191. Scardapane A, Brucato A, Chiarelli F, Breda L. Efficacy of an interleukin-1β receptor antagonist (anakinra) in idiopathic recurrent pericarditis. Pediatr Cardiol. 2013;34(8):1989-1991. doi: 10.1007/s00246-012-0532-0

192. Finetti M, Insalaco A, Cantarini L, Meini A, Breda L, Alessio M, et al. Long-term efficacy of interleukin-1 receptor antagonist (anakinra) in corticosteroid-dependent and colchicine-resistant recurrent pericarditis. J Pediatr. 2014;164(6):1425-1431.e1. doi: 10.1016/j.jpeds.2014.01.065

193. Camacho-Lovillo M, Méndez-Santos A. Successful treatment of idiopathic recurrent pericarditis with interleukin-1 receptor antagonist (Anakinra). Pediatr Cardiol. 2013;34(5):1293-1294. doi: 10.1007/s00246-013-0663-y

194. Andreis A, Imazio M, Giustetto C, Brucato A, Adler Y, De Ferrari GM. Anakinra for constrictive pericarditis associated with incessant or recurrent pericarditis. Heart. 2020;106(20): 1561-1565. doi: 10.1136/heartjnl-2020-316898

195. Jain S, Thongprayoon C, Espinosa RE, Hayes SN, Klarich KW, Cooper LT, et al. Effectiveness and safety of anakinra for management of refractory pericarditis. Am J Cardiol. 2015;116(8):1277-1279. doi: 10.1016/j.amjcard.2015.07.047

196. Vassilopoulos D, Lazaros G, Tsioufis C, Vasileiou P, Stefanadis C, Pectasides D. Successful treatment of adult patients with idiopathic recurrent pericarditis with an interleukin-1 receptor antagonist (anakinra). Int J Cardiol. 2012;160(1):66-68. doi: 10.1016/j.ijcard.2012.05.086

197. Lazaros G, Vasileiou P, Koutsianas C, Antonatou K, Stefanadis C, Pectasides D, et al. Anakinra for the management of resistant idiopathic recurrent pericarditis. Initial experience in 10 adult cases. Ann Rheum Dis. 2014;73(12):2215-2217. doi: 10.1136/annrheumdis-2014-205990

198. Lazaros G, Vasileiou P, Danias P, Koutsianas C, Vlachopoulos C, Tousoulis D, et al. Effusive-constrictive pericarditis successfully treated with anakinra. Clin Exp Rheumatol. 2015;33(6):945.

199. D’Elia E, Brucato A, Pedrotti P, Valenti A, De Amici M, Fiocca L, et al. Successful treatment of subacute constrictive pericarditis with interleukin-1β receptor antagonist (anakinra). Clin Exp Rheumatol. 2015;33(2):294-295.

200. Cavalli G, Foppoli M, Cabrini L, Dinarello CA, Tresoldi M, Dagna L. Interleukin-1 receptor blockade rescues myocarditisassociated end-stage heart failure. Front Immunol. 2017;8:131. doi: 10.3389/fimmu.2017.00131

201. Schatz A, Trankle C, Yassen A, Chipko C, Rajab M, Abouzaki N, et al. Resolution of pericardial constriction with Anakinra in a patient with effusive-constrictive pericarditis secondary to rheumatoid arthritis. Int J Cardiol. 2016;223:215-216. doi: 10.1016/j.ijcard.2016.08.131

202. Raffeiner B, Botsios C, Dinarello C, Ometto F, Punzi L, Ramonda R. Adult-onset Still’s disease with myocarditis successfully treated with the interleukin-1 receptor antagonist anakinra. Joint Bone Spine. 2011;78(1):100-101. doi: 10.1016/j.jbspin.2010.09.014

203. Thallapally VK, Gupta S, Gundepalli SG, Nahas J. Use of Anakinra in steroid dependent recurrent pericarditis: A case report and review of literature. J Community Hosp Intern Med Perspect. 2021;11(4):543-546. doi: 10.1080/20009666.2021.1933716

204. Rodriguez-Gonzalez M, Ruiz-Gonzalez E, CastellanoMartinez A. Anakinra as rescue therapy for steroid-dependent idiopathic recurrent pericarditis in children: Case report and literature review. Cardiol Young. 2019;29(2):241-243. doi: 10.1017/S1047951118002020

205. Wohlford GF, Buckley LF, Vecchié A, Kadariya D, Markley R, Trankle CR, et al. Acute effects of interleukin-1 blockade using anakinra in patients with acute pericarditis. J Cardiovasc Pharmacol. 2020;76(1):50-52. doi: 10.1097/FJC.0000000000000847

206. Dagan A, Langevitz P, Shoenfeld Y, Shovman O. Anakinra in idiopathic recurrent pericarditis refractory to immunosuppressive therapy; a preliminary experience in seven patients. Autoimmun Rev. 2019;18(6):627-631. doi: 10.1016/j.autrev.2019.01.005

207. Imazio M, Andreis A, Piroli F, Lazaros G, Gattorno M, Lewinter M, et al. Anti-interleukin 1 agents for the treatment of recurrent pericarditis: A systematic review and meta-analysis. Heart. 2021:heartjnl-2020-318869. doi: 10.1136/heartjnl-2020-318869

208. Van Tassell BW, Abouzaki NA, Oddi Erdle C, Carbone S, Trankle CR, Melchior RD, et al. Interleukin-1 blockade in acute decompensated heart failure: A randomized, double-blinded, placebo-controlled pilot study. J Cardiovasc Pharmacol. 2016;67(6):544-551. doi: 10.1097/FJC.0000000000000378

209. Van Tassell BW, Canada J, Carbone S, Trankle C, Buckley L, Oddi Erdle C, et al. Interleukin-1 blockade in recently decompensated systolic heart failure: results from REDHART (Recently Decompensated Heart Failure Anakinra Response Trial). Circ Heart Fail. 2017;10(11):e004373. doi: 10.1161/CIRCHEARTFAILURE.117.004373

210. Van Tassell BW, Trankle CR, Canada JM, Carbone S, Buckley L, Kadariya D, et al. IL-1 blockade in patients with heart failure with preserved ejection fraction. Circ Heart Fail. 2018;11(8):e005036. doi: 10.1161/CIRCHEARTFAILURE.118.005036

211. Abbate A, Van Tassell BW, Biondi-Zoccai G, Kontos MC, Grizzard JD, Spillman DW, et al. Effects of interleukin-1 blockade with anakinra on adverse cardiac remodeling and heart failure after acute myocardial infarction [from the Virginia Commonwealth University-Anakinra Remodeling Trial (2) (VCU-ART2) pilot study]. Am J Cardiol. 2013;111(10):1394-1400. doi: 10.1016/j.amjcard.2013.01.287

212. Van Tassell BW, Arena R, Biondi-Zoccai G, Canada JM, Oddi C, Abouzaki NA, et al. Effects of interleukin-1 blockade with anakinra on aerobic exercise capacity in patients with heart failure and preserved ejection fraction (from the D-HART pilot study). Am J Car diol. 2014;113(2):321-327. doi: 10.1016/j.amjcard.2013.08.047

213. Saad Shaukat MH, Shabbir MA, Singh S, Torosoff M, PeredoWende R. Anakinra for colchicine-intolerant/colchicine-resistant acute gout flare precipitated by decompensated heart failure. Ir J Med Sci. 2021;190(1):129-131. doi: 10.1007/s11845-020-02322-3

214. Sonnino C, Christopher S, Oddi C, Toldo S, Falcao RA, Melchior RD, et al. Leukocyte activity in patients with ST-segment elevation acute myocardial infarction treated with anakinra. Mol Med. 2014;20(1):486-489. doi: 10.2119/molmed.2014.00121

215. Canada JM, Van Tassell BW, Christopher S, Oddi C, Abouzaki NA, Gambill ML, et al. Clinical predictors of response to anakinra in patients with heart failure. Int J Cardiol. 2014;173(3):537-539. doi: 10.1016/j.ijcard.2014.03.023

216. Abbate A, Kontos MC, Abouzaki NA, Melchior RD, Thomas C, Van Tassell BW, et al. Comparative safety of interleukin-1 blockade with anakinra in patients with ST-segment elevation acute myocardial infarction (from the VCU-ART and VCU-ART2 pilot studies). Am J Cardiol. 2015;115(3):288-292. doi: 10.1016/j.amjcard.2014.11.003

217. Abbate A, Trankle CR, Buckley LF, Lipinski MJ, Appleton D, Kadariya D, et al. Interleukin-1 blockade inhibits the acute inflammatory response in patients with ST-segment-elevation myocardial infarction. J Am Heart Assoc. 2020;9(5):e014941. doi: 10.1161/JAHA.119.014941

218. Abbate A, Wohlford GF, Del Buono MG, Chiabrando JG, Markley R, Turlington J, et al. Interleukin-1 blockade with Anakinra and heart failure following ST-segment elevation myocardial infarction: results from a pooled analysis of the VCUART clinical trials. Eur Heart J Cardiovasc Pharmacother. 2021 Oct 7:pvab075. doi: 10.1093/ehjcvp/pvab075

219. Del Buono MG, Damonte JI, Trankle CR, Kadariya D, Carbone S, Thomas G, et al. Effect of interleukin-1 blockade with anakinra on leukocyte count in patients with ST-segment elevation acute myocardial infarction. Sci Rep. 2022;12(1):1254. doi: 10.1038/s41598-022-05374-w

220. De Vita S, De Biasio M, Zabotti A, Morocutti G, Quartuccio L, De Marchi G, et al. Successful treatment of complicated pericarditis after myocardial infarction with interleukin-1 blocker. Rheumatology (Oxford). 2020;59(2):445-447. doi: 10.1093/rheumatology/kez307

221. Noji Y. Anakinra in fulminant myocarditis: Targeting interleukin-1 and the inflammasome formation. Crit Care Med. 2016;44(8):1630-1631. doi: 10.1097/CCM.0000000000001769

222. Cavalli G, Pappalardo F, Mangieri A, Dinarello CA, Dagna L, Tresoldi M. Treating life-threatening myocarditis by blocking interleukin-1. Crit Care Med. 2016;44(8):e751-e754. doi: 10.1097/CCM.0000000000001654

223. Bello F, Marchi A, Prisco D, Olivotto I, Emmi G. Antiarrhythmic efficacy of anakinra in a young patient with autoimmune lymphocytic myocarditis. Rheumatology (Oxford). 2020;59(11):e88-e90. doi: 10.1093/rheumatology/keaa207

224. De Luca G, Campochiaro C, Dinarello CA, Dagna L, Cavalli G. Treatment of dilated cardiomyopathy with interleukin-1 inhibition. Ann Intern Med. 2018;169(11):819-820. doi: 10.7326/L18-0315

225. Lopalco G, Venerito V, Brucato A, Emmi G, Giacomelli R, Cauli A, et al. Anakinra effectiveness in refractory polyserositis: An Italian multicenter study. Joint Bone Spine. 2022;89(2):105299. doi: 10.1016/j.jbspin.2021.105299

226. Cohen S, Tacke CE, Straver B, Meijer N, Kuipers IM, Kuijpers TW. A child with severe relapsing Kawasaki disease rescued by IL-1 receptor blockade and extracorporeal membrane oxygenation. Ann Rheum Dis. 2012;71(12):2059-2061. doi: 10.1136/annrheumdis-2012-201658

227. Shafferman A, Birmingham JD, Cron RQ. High dose Anakinra for treatment of severe neonatal Kawasaki disease: A case report. Pediatr Rheumatol Online J. 2014;12:26. doi: 10.1186/1546-0096-12-26

228. Sánchez-Manubens J, Gelman A, Franch N, Teodoro S, Palacios JR, Rudi N, et al. A child with resistant Kawasaki disease successfully treated with anakinra: A case report. BMC Pediatr. 2017;17(1):102. doi: 10.1186/s12887-017-0852-6

229. Guillaume MP, Reumaux H, Dubos F. Usefulness and safety of anakinra in refractory Kawasaki disease complicated by coronary artery aneurysm. Cardiol Young. 2018;28(5):739-742. doi: 10.1017/S1047951117002864

230. Blonz G, Lacroix S, Benbrik N, Warin-Fresse K, Masseau A, Trewick D, et al. Severe late-onset Kawasaki disease successfully treated with anakinra. J Clin Rheumatol. 2020;26(2):e42-e43. doi: 10.1097/RHU.0000000000000814

231. Kone-Paut I, Cimaz R, Herberg J, Bates O, Carbasse A, Saulnier JP, et al. The use of interleukin 1 receptor antagonist (anakinra) in Kawasaki disease: A retrospective cases series. Autoimmun Rev. 2018;17(8):768-774. doi: 10.1016/j.autrev.2018.01.024

232. Flinn AM, Gavin PJ, McMahon CJ, Oslizok P, Butler KM. Kawasaki disease – A review of treatment and outcomes in an Irish paediatric cohort 2010-14. Ir Med J. 2018;111(2):691.

233. Gamez-Gonzalez LB, Moribe-Quintero I, Cisneros-Castolo M, Varela-Ortiz J, Muñoz-Ramírez M, Garrido-García M, et al. Kawasaki disease shock syndrome: Unique and severe subtype of Kawasaki disease. Pediatr Int. 2018;60(9):781-790. doi: 10.1111/ped.13614

234. Lind-Holst M, Hartling UB, Christensen AE. High-dose anakinra as treatment for macrophage activation syndrome caused by refractory Kawasaki disease in an infant. BMJ Case Rep. 2019;12(8):e229708. doi: 10.1136/bcr-2019-229708

235. Maggio MC, Cimaz R, Alaimo A, Comparato C, Di Lisi D, Corsello G. Kawasaki disease triggered by parvovirus infection: An atypical case report of two siblings. J Med Case Rep. 2019;13(1):104. doi: 10.1186/s13256-019-2028-5

236. Mastrolia MV, Abbati G, Signorino C, Maccora I, Marrani E, Pagnini I, et al. Early anti IL-1 treatment replaces steroids in refractory Kawasaki disease: Clinical experience from two case reports. Ther Adv Musculoskelet Dis. 2021;13:1759720X211002593. doi: 10.1177/1759720X211002593

237. Gambacorta A, Buonsenso D, De Rosa G, Lazzareschi I, Gatto A, Brancato F, et al. Resolution of giant coronary aneurisms in a child with refractory Kawasaki disease treated with anakinra. Front Pediatr. 2020;8:195. doi: 10.3389/fped.2020.00195

238. Ferrara G, Giani T, Caparello MC, Farella C, Gamalero L, Cimaz R. Anakinra for treatment-resistant Kawasaki disease: Evidence from a literature review. Paediatr Drugs. 2020;22(6):645-652. doi: 10.1007/s40272-020-00421-3

239. Sönmez HE, Demir S, Bilginer Y, Özen S. Anakinra treatment in macrophage activation syndrome: A single center experience and systemic review of literature. Clin Rheumatol. 2018;37(12):3329-3335. doi: 10.1007/s10067-018-4095-1

240. Phadke O, Rouster-Stevens K, Giannopoulos H, Chandrakasan S, Prahalad S. Intravenous administration of anakinra in children with macrophage activation syndrome. Pediatr Rheumatol Online J. 2021;19(1):98. doi: 10.1186/s12969-021-00585-3

241. Eloseily EM, Weiser P, Crayne CB, Haines H, Mannion ML, Stoll ML, et al. Benefit of anakinra in treating pediatric secondary hemophagocytic lymphohistiocytosis. Arthritis Rheumatol. 2020;72(2):326-334. doi: 10.1002/art.41103

242. Eloseily EM, Weiser P, Crayne CB, Haines H, Mannion ML, Stoll ML, et al. Benefit of anakinra in treating pediatric secondary hemophagocytic lymphohistiocytosis. Arthritis Rheumatol. 2020;72(2):326-334. doi: 10.1002/art.41103

243. Hines MR, von Bahr Greenwood T, Beutel G, Beutel K, Hays JA, Horne A, et al. Consensus-based guidelines for the recognition, diagnosis, and management of hemophagocytic lymphohistiocytosis in critically ill children and adults. Crit Care Med. 2022;50(5): 860-872. doi: 10.1097/CCM.0000000000005361

244. Kübler L, Bittmann I, Kuipers JG. Macrophage activation syndrome triggered by active systemic lupus erythematosus: Successful treatment by interleukin-1 inhibition (anakinra). Z Rheumatol. 2020;79(10):1040-1045. doi: 10.1007/s00393-020-00836-w

245. CORIMUNO-19 Collaborative group. Effect of anakinra versus usual care in adults in hospital with COVID-19 and mild-to-moderate pneumonia (CORIMUNO-ANA-1): A randomised controlled trial. Lancet Respir Med. 2021;9(3):295-304. doi: 10.1016/S2213-2600(20)30556-7

246. Kyriazopoulou E, Poulakou G, Milionis H, Metallidis S, Adamis G, Tsiakos K, et al. Early treatment of COVID-19 with anakinra guided by soluble urokinase plasminogen receptor plasma levels: A doubleblind, randomized controlled phase 3 trial. Nat Med. 2021;27(10): 1752-1760. doi: 10.1038/s41591-021-01499-z

247. Cauchois R, Koubi M, Delarbre D, Manet C, Carvelli J, Blasco VB, et al. Early IL-1 receptor blockade in severe inflammatory respiratory failure complicating COVID-19. Proc Natl Acad Sci U S A. 2020;117(32):18951-18953. doi: 10.1073/pnas.2009017117

248. Huet T, Beaussier H, Voisin O, Jouveshomme S, Dauriat G, Lazareth I, et al. Anakinra for severe forms of COVID-19: A cohort study. Lancet Rheumatol. 2020;2(7):e393-e400. doi: 10.1016/S2665-9913(20)30164-8

249. Bozzi G, Mangioni D, Minoia F, Aliberti S, Grasselli G, Barbetta L, et al. Anakinra combined with methylprednisolone in patients with severe COVID-19 pneumonia and hyperinflammation: An observational cohort study. J Allergy Clin Immunol. 2021;147(2):561-566.e4. doi: 10.1016/j.jaci.2020.11.006

250. Cavalli G, De Luca G, Campochiaro C, Della-Torre E, Ripa M, Canetti D, et al. Interleukin-1 blockade with high-dose anakinra in patients with COVID-19, acute respiratory distress syndrome, and hyperinflammation: A retrospective cohort study. Lancet Rheumatol. 2020;2(6):e325-e331. doi: 10.1016/S2665-9913(20)30127-2

251. Pontali E, Volpi S, Signori A, Antonucci G, Castellaneta M, Buzzi D, et al. Efficacy of early anti-inflammatory treatment with high doses of intravenous anakinra with or without glucocorticoids in patients with severe COVID-19 pneumonia. J Allergy Clin Immunol. 2021;147(4):1217-1225. doi: 10.1016/j.jaci.2021.01.024

252. Kooistra EJ, Waalders NJB, Grondman I, Janssen NAF, de Nooijer AH, Netea MG, et al.; RCI-COVID-19 Study Group. Anakinra treatment in critically ill COVID-19 patients: A prospective cohort study. Crit Care. 2020;24(1):688. doi: 10.1186/s13054-020-03364-w

253. Kyriazopoulou E, Panagopoulos P, Metallidis S, Dalekos GN, Poulakou G, Gatselis N, et al. An open label trial of anakinra to prevent respiratory failure in COVID-19. Elife. 2021;10:e66125. doi: 10.7554/eLife.66125

254. Balkhair A, Al-Zakwani I, Al Busaidi M, Al-Khirbash A, Al Mubaihsi S, BaTaher H, et al. Anakinra in hospitalized patients with severe COVID-19 pneumonia requiring oxygen therapy: Results of a prospective, open-label, interventional study. Int J Infect Dis. 2021;103:288-296. doi: 10.1016/j.ijid.2020.11.149

255. Kyriazopoulou E, Huet T, Cavalli G, Gori A, Kyprianou M, Pickkers P; International Collaborative Group for Anakinra in COVID-19. Effect of anakinra on mortality in patients with COVID-19: A systematic review and patient-level metaanalysis. Lancet Rheumatol. 2021;3(10):e690-e697. doi: 10.1016/S2665-9913(21)00216-2

256. Wang Y, Zhu K, Dai R, Li R, Li M, Lv X, et al. Specific interleukin-1 inhibitors, specific interleukin-6 inhibitors, and GM-CSF blockades for COVID-19 (at the edge of sepsis): A systematic review. Front Pharmacol. 2022;12:804250. doi: 10.3389/fphar.2021.804250

257. Muscari I, Iacoponi F, Cantarini L, Lucherini OM, Simonini G, Brizi MG, et al. The diagnostic evaluation of patients with potential adult-onset autoinflammatory disorders: Our experience and review of the literature. Autoimmun Rev. 2012;12(1):10-13. doi: 10.1016/j.autrev.2012.07.015

258. Gaggiano C, Rigante D, Vitale A, Lucherini OM, Fabbiani A, Capozio G, et al. Hints for genetic and clinical differentiation of adult-onset monogenic autoinflammatory diseases. Mediators Inflamm. 2019;2019:3293145. doi: 10.1155/2019/3293145

259. Салугина СО, Федоров ЕС, Агафонова ЕМ. Моногенные аутовоспалительные заболевания у детей и взрослых: что необходимо знать ревматологу. Научно-практическая ревматология. 2019;57(2):125-132. doi: 10.14412/1995-4484-2019-125-132

260. Yao Q, Zhou L, Cusumano P, Bose N, Piliang M, Jayakar B, et al. A new category of autoinflammatory disease associated with NOD2 gene mutations. Arthritis Res Ther. 2011;13(5):R148. doi: 10.1186/ar3462

261. Yao Q, Shen M, McDonald C, Lacbawan F, Moran R, Shen B. NOD2-associated autoinflammatory disease: A large cohort study. Rheumatology (Oxford). 2015;54(10):1904-1912. doi: 10.1093/rheumatology/kev207

262. Federici S, Sormani MP, Ozen S, Lachmann HJ, Amaryan G, Woo P, et al.; Paediatric Rheumatology International Trials Organisation (PRINTO) and Eurofever Project. Evidence-based provisional clinical classification criteria for autoinflammatory periodic fevers. Ann Rheum Dis. 2015;74(5):799-805. doi: 10.1136/annrheumdis-2014-206580

263. Rigante D, Vitale A, Lucherini OM, Cantarini L. The hereditary autoinflammatory disorders uncovered. Autoimmun Rev. 2014;13(9):892-900. doi: 10.1016/j.autrev.2014.08.001

264. Demir F, Doğan ÖA, Demirkol YK, Tekkuş KE, Canbek S, Karadağ ŞG, et al. Genetic panel screening in patients with clinically unclassified systemic autoinflammatory diseases. Clin Rheumatol. 2020;39(12):3733-3745. doi: 10.1007/s10067-020-05108-1

265. Yao Q, Lacbawan F, Li J. Adult autoinflammatory disease frequency and our diagnostic experience in an adult autoinflammatory clinic. Semin Arthritis Rheum. 2016;45(5):633-637. doi: 10.1016/j.semarthrit.2015.10.012

266. Hua Y, Wu D, Shen M, Yu K, Zhang W, Zeng X. Phenotypes and genotypes of Chinese adult patients with systemic autoinflammatory diseases. Semin Arthritis Rheum. 2019;49(3):446-452. doi: 10.1016/j.semarthrit.2019.05.002

267. Yamaguchi M, Ohta A, Tsunematsu T, Kasukawa R, Mizushima Y, Kashiwagi H, et al. Preliminary criteria for classification of adult Still’s disease. J Rheumatol. 1992;19(3):424-430.

268. Fautrel B, Zing E, Golmard JL, Le Moel G, Bissery A, Rioux C, et al. Proposal for a new set of classification criteria for adultonset Still disease. Medicine (Baltimore). 2002;81(3):194-200. doi: 10.1097/00005792-200205000-00003

269. Livneh A, Langevitz P, Zemer D, Zaks N, Kees S, Lidar T, et al. Criteria for the diagnosis of familial Mediterranean fever. Arthritis Rheum. 1997;40(10):1879-1885. doi: 10.1002/art.1780401023

270. Yalçinkaya F, Ozen S, Ozçakar ZB, Aktay N, Cakar N, Düzova A, et al. A new set of criteria for the diagnosis of familial Mediterranean fever in childhood. Rheumatology (Oxford). 2009;48(4):395-398. doi: 10.1093/rheumatology/ken509

271. Kuemmerle-Deschner JB, Ozen S, Tyrrell PN, Kone-Paut I, Goldbach-Mansky R, Lachmann H, et al. Diagnostic criteria for cryopyrin-associated periodic syndrome (CAPS). Ann Rheum Dis. 2017;76(6):942-947. doi: 10.1136/annrheumdis-2016-209686

272. Simon A, Asli B, Braun-Falco M, De Koning H, Fermand JP, Grattan C, et al. Schnitzler’s syndrome: Diagnosis, treatment, and follow-up. Allergy. 2013;68(5):562-568. doi: 10.1111/all.12129

273. Cantarini L, Vitale A, Sicignano LL, Emmi G, Verrecchia E, Patisso I, et al. Diagnostic criteria for adult-onset periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome. Front Immunol. 2017;8:1018. doi: 10.3389/fimmu.2017.01018

274. International Team for the Revision of the International Criteria for Behçet’s Disease (ITR-ICBD). The International Criteria for Behçet’s Disease (ICBD): A collaborative study of 27 countries on the sensitivity and specificity of the new criteria. J Eur Acad Dermatol Venereol. 2014;28(3):338-347. doi: 10.1111/jdv.12107

275. Попкова ТВ, Новикова ДС, Насонов ЕЛ. Сердечнососудистые заболевания при ревматоидном артрите: новые данные. Научно-практическая ревматология. 2016;54(2):122-128. doi: 10.14412/1995-4484-2016-122-128

276. Atzeni F, Rodríguez-Carrio J, Popa CD, Nurmohamed MT, Szűcs G, Szekanecz Z. Cardiovascular effects of approved drugs for rheumatoid arthritis. Nat Rev Rheumatol. 2021;17(5):270-290. doi: 10.1038/s41584-021-00593-3

277. Ferguson LD, Siebert S, McInnes IB, Sattar N. Cardiometabolic comorbidities in RA and PsA: Lessons learned and future directions. Nat Rev Rheumatol. 2019;15(8):461-474. doi: 10.1038/s41584-019-0256-0

278. Tian Z, Mclaughlin J, Verma A, Chinoy H, Heald AH. The relationship between rheumatoid arthritis and diabetes mellitus: A systematic review and meta-analysis. Cardiovasc Endocrinol Metab. 2021;10(2):125-131. doi: 10.1097/XCE.0000000000000244

279. Verma AK, Bhatt D, Goyal Y, Dev K, Beg MMA, Alsahli MA, et al. Association of rheumatoid arthritis with diabetic comorbidity: Correlating accelerated insulin resistance to inflammatory responses in patients. J Multidiscip Healthc. 2021;14:809-820. doi: 10.2147/JMDH.S285469

280. Baker JF, England BR, George M, Cannon G, Sauer B, Ogdie A, et al. Disease activity, cytokines, chemokines and the risk of incident diabetes in rheumatoid arthritis. Ann Rheum Dis. 2021;80(5):566-572. doi: 10.1136/annrheumdis-2020-219140

281. Cano-Cano F, Gómez-Jaramillo L, Ramos-García P, Arroba AI, Aguilar-Diosdado M. IL-1β implications in type 1 diabetes mellitus progression: Systematic review and meta-analysis. J Clin Med. 2022;11(5):1303. doi: 10.3390/jcm11051303

282. Larsen CM, Faulenbach M, Vaag A, Vølund A, Ehses JA, Seifert B, et al. Interleukin-1-receptor antagonist in type 2 diabetes mellitus. N Engl J Med. 2007;356(15):1517-1526. doi: 10.1056/NEJMoa065213

283. van Asseldonk EJ, van Poppel PC, Ballak DB, Stienstra R, Netea MG, Tack CJ. One week treatment with the IL-1 receptor antagonist anakinra leads to a sustained improvement in insulin sensitivity in insulin resistant patients with type 1 diabetes mellitus. Clin Immunol. 2015;160(2):155-162. doi: 10.1016/j.clim.2015.06.003

284. Moran A, Bundy B, Becker DJ, DiMeglio LA, Gitelman SE, Goland R, et al.; AIDA Study Group. Interleukin-1 antagonism in type 1 diabetes of recent onset: two multicentre, randomised, double-blind, placebo-controlled trials. Lancet. 2013;381(9881):1905-1915. doi: 10.1016/S0140-6736(13)60023-9

285. van Poppel PC, van Asseldonk EJ, Holst JJ, Vilsbøll T, Netea MG, Tack CJ. The interleukin-1 receptor antagonist anakinra improves first-phase insulin secretion and insulinogenic index in subjects with impaired glucose tolerance. Diabetes Obes Metab. 2014;16(12):1269-1273. doi: 10.1111/dom.12357

286. Ruscitti P, Ursini F, Cipriani P, Greco M, Alvaro S, Vasiliki L, et al. IL-1 inhibition improves insulin resistance and adipokines in rheumatoid arthritis patients with comorbid type 2 diabetes: An observational study. Medicine (Baltimore). 2019;98(7):e14587. doi: 10.1097/MD.0000000000014587

287. Ahlers MJ, Lowery BD, Farber-Eger E, Wang TJ, Bradham W, Ormseth MJ, et al. Heart failure risk associated with rheumatoid arthritis-related chronic inflammation. J Am Heart Assoc. 2020;9(10):e014661. doi: 10.1161/JAHA.119.014661

288. Khalid Y, Dasu N, Shah A, Brown K, Kaell A, Levine A, et al. Incidence of congestive heart failure in rheumatoid arthritis: A review of literature and meta-regression analysis. ESC Heart Fail. 2020;7(6):3745-3753. doi: 10.1002/ehf2.12947

289. Setoguchi S, Schneeweiss S, Avorn J, Katz JN, Weinblatt ME, Levin R, et al. Tumor necrosis factor-alpha antagonist use and heart failure in elderly patients with rheumatoid arthritis. Am Heart J. 2008;156(2):336-341. doi: 10.1016/j.ahj.2008.02.025

290. Fraenkel L, Bathon JM, England BR, St Clair EW, Arayssi T, Carandang K, et al. 2021 American College of Rheumatology guideline for the treatment of rheumatoid arthritis. Arthritis Rheumatol. 2021;73(7):1108-1123. doi: 10.1002/art.41752

291. Kontzias A, Barkhodari A, Yao Q. Pericarditis in systemic rheumatologic diseases. Curr Cardiol Rep. 2020;22(11):142. doi: 10.1007/s11886-020-01415-w

292. Mouradjian MT, Plazak ME, Gale SE, Noel ZR, Watson K, Devabhakthuni S. Pharmacologic management of gout in patients with cardiovascular disease and heart failure. Am J Cardiovasc Drugs. 2020;20(5):431-445. doi: 10.1007/s40256-020-00400-6

293. Ritter F, Franzeck F, Geisshardt J, Walker UA, Osthoff M. Gout arthritis during admission for decompensated heart failure – A descriptive analysis of risk factors, treatment and prognosis. Front Med (Lausanne). 2022;9:789414. doi: 10.3389/fmed.2022.789414

294. Vitale A, Cantarini L, Rigante D, Bardelli M, Galeazzi M. Anakinra treatment in patients with gout and type 2 diabetes. Clin Rheumatol. 2015;34(5):981-984. doi: 10.1007/s10067-014-2601-7

295. Savic S, Mistry A, Wilson AG, Barcenas-Morales G, Doffinger R, Emery P, et al. Autoimmune-autoinflammatory rheumatoid arthritis overlaps: A rare but potentially important subgroup of diseases. RMD Open. 2017;3(2):e000550. doi: 10.1136/rmdopen-2017-000550

296. Walterscheid B, Nguyen J, Gadwala S, Shome G, Tarbox M, Tarbox JA. Familial cold autoinflammatory syndrome with rheumatoid arthritis. Proc (Bayl Univ Med Cent). 2021;34(5):603-605. doi: 10.1080/08998280.2021.1913042

297. Mitrovic S, Fautrel B. Clinical phenotypes of adult-onset Still’s disease: New insights from pathophysiology and literature findings. J Clin Med. 2021;10(12):2633. doi: 10.3390/jcm10122633

298. Cuervo A, Sanmartí R, Ramírez J, Castellanos-Moreira R, Inciarte-Mundo J, Aróstegui JI, et al. Palindromic rheumatism: Evidence of four subtypes of palindromic-like arthritis based in either MEFV or rheumatoid factor/ACPA status. Joint Bone Spine. 2021;88(6):105235. doi: 10.1016/j.jbspin.2021.105235

299. Tani Y, Kishi T, Miyamae T, Kawamoto M, Kawaguchi Y, Taniguchi A, et al. The evaluation of gene polymorphisms associated with autoinflammatory syndrome in patients with palindromic rheumatism complicated by intermittent hydrarthrosis. Clin Rheumatol. 2020;39(3):841-845. doi: 10.1007/s10067-019-04883-w

300. Cañete JD, Arostegui JI, Queiró R, Gratacós J, Hernández MV, Larrosa M, et al. An unexpectedly high frequency of MEFV mutations in patients with anti-citrullinated protein antibodynegative palindromic rheumatism. Arthritis Rheum. 2007;56(8):2784-2788. doi: 10.1002/art.22755

301. Cutolo M, Cimmino MA, Sulli A. Polymyalgia rheumatica vs late-onset rheumatoid arthritis. Rheumatology (Oxford). 2009;48(2):93-95. doi: 10.1093/rheumatology/ken294

302. Caporali R, Montecucco C, Epis O, Bobbio-Pallavicini F, Maio T, Cimmino MA. Presenting features of polymyalgia rheumatica (PMR) and rheumatoid arthritis with PMR-like onset: A prospective study. Ann Rheum Dis. 2001;60(11):1021-1024. doi: 10.1136/ard.60.11.1021

303. Floris A, Piga M, Cauli A, Salvarani C, Mathieu A. Polymyalgia rheumatica: An autoinflammatory disorder? RMD Open. 2018;4(1):e000694. doi: 10.1136/rmdopen-2018-000694

304. Mitrovic S, Hassold N, Kamissoko A, Rosine N, Mathian A, Mercy G, et al. Adult-onset Still’s disease or systemic-onset juvenile idiopathic arthritis and spondyloarthritis: Overlapping syndrome or phenotype shift? Rheumatology (Oxford). 2022;61(6): 2535-2547. doi: 10.1093/rheumatology/keab726

305. Matsuoka N, Iwanaga J, Ichinose Y, Fujiyama K, Tsuboi M, Kawakami A, et al. Two elderly cases of familial mediterranean fever with rheumatoid arthritis. Int J Rheum Dis. 2018;21(10):1873-1877. doi: 10.1111/1756-185X.12354

306. Yago T, Asano T, Fujita Y, Migita K. Familial Mediterranean fever phenotype progression into anti-cyclic citrullinated peptide antibody-positive rheumatoid arthritis: A case report. Fukushima J Med Sci. 2020;66(3):160-166. doi: 10.5387/fms.2020-07

307. Rajabally MN, Watermeyer GA, Levin DA. A case of Crohn’s disease complicated by adult onset Still’s disease. J Crohns Colitis. 2010;4(4):475-478. doi: 10.1016/j.crohns.2010.02.010

308. Katsanos KH, Siozopoulou V, Sigounas D, Tsianos VE, Christodoulou D, Mitsi V, et al. Adult-onset Still’s disease preceding Crohn’s disease. J Crohns Colitis. 2013;7(3):e93-e98. doi: 10.1016/j.crohns.2012.05.019

309. Kono M, Oshitani N, Sawa Y, Watanabe K, Kamata N, Oiso R, et al. Crohn’s disease complicated by adult-onset Still’s disease. J Gastroenterol. 2003;38(9):891-895. doi: 10.1007/s00535-002-1167-3

310. Semiz H, Kobak S. Coexistence of sarcoidosis and adult onset Still disease. Reumatol Clin (Engl Ed). 2019;15(5):e18-e20. doi: 10.1016/j.reuma.2017.04.004

311. Ganhão S, Ferreira RM, Guerra M, Furtado A, Águeda A, Mariz E, et al. Adult-onset Still’s disease in a patient with a previous diagnosis of acute sarcoidosis: A rare association. J Clin Rheumatol. 2021;27(7):e271. doi: 10.1097/RHU.0000000000001404

312. Beck DB, Ferrada MA, Sikora KA, Ombrello AK, Collins JC, Pei W, et al. Somatic mutations in UBA1 and severe adult-onset autoinflammatory disease. N Engl J Med. 2020;383(27):2628-2638. doi: 10.1056/NEJMoa2026834

313. van der Made CI, Potjewijd J, Hoogstins A, Willems HPJ, Kwakernaak AJ, de Sevaux RGL, et al. Adult-onset autoinflammation caused by somatic mutations in UBA1: A Dutch case series of patients with VEXAS. J Allergy Clin Immunol. 2022;149(1):432-439.e4. doi: 10.1016/j.jaci.2021.05.014

314. Delplanque M, Aouba A, Hirsch P, Fenaux P, Graveleau J, Malard F, et al. USAID associated with myeloid neoplasm and VEXAS syndrome: Two differential diagnoses of suspected adult onset Still’s disease in elderly patients. J Clin Med. 2021;10(23):5586. doi: 10.3390/jcm10235586

315. Kacar M, Pathak S, Savic S. Hereditary systemic autoinflammatory diseases and Schnitzler’s syndrome. Rheumatology (Oxford). 2019;58(Suppl 6):vi31-vi43. doi: 10.1093/rheumatology/kez448

316. Fujita Y, Asano T, Sakai A, Norikawa N, Yamamoto T, Matsumoto H, et al. A case of Schnitzler’s syndrome without monoclonal gammopathy successfully treated with canakinumab. BMC Musculoskelet Disord. 2021;22(1):257. doi: 10.1186/s12891-021-04120-z

317. Gusdorf L, Lipsker D. Neutrophilic urticarial dermatosis: An entity bridging monogenic and polygenic autoinflammatory disorders, and beyond. J Eur Acad Dermatol Venereol. 2020;34(4):685-690. doi: 10.1111/jdv.15984

318. Hartig I, Schroeder JO, Mrowietz U. Neutrophilic urticarial dermatosis (NUD) in probable adult-onset Still disease responding to anakinra. J Clin Rheumatol. 2014;20(2):96-98. doi: 10.1097/RHU.0000000000000078

319. Oganesyan A, Hakobyan Y, Terrier B, Georgin-Lavialle S, Mekinian A. Looking beyond VEXAS: Coexistence of undifferentiated systemic autoinflammatory disease and myelodysplastic syndrome. Semin Hematol. 2021;58(4):247-253. doi: 10.1053/j.seminhematol.2021.10.003

320. Petsch C, Araujo EG, Englbrecht M, Bayat S, Cavallaro A, Hueber AJ, et al. Prevalence of monosodium urate deposits in a population of rheumatoid arthritis patients with hyperuricemia. Semin Arthritis Rheum. 2016;45(6):663-668. doi: 10.1016/j.semarthrit.2015.11.014

321. Nada D, Gaber R, Mahmoud AS, Elkhouly R, Alashkar D. Hyperuricemia among Egyptian rheumatoid arthritis patients. Is it an association or an inflammatory marker? A cross-sectional observational study. Open Access Rheumatol. 2021;13:305-314. doi: 10.2147/OARRR.S331488

322. Chiou A, England BR, Sayles H, Thiele GM, Duryee MJ, Baker JF, et al. Coexistent hyperuricemia and gout in rheumatoid arthritis: Associations with comorbidities, disease activity, and mortality. Arthritis Care Res (Hoboken). 2020;72(7):950-958. doi: 10.1002/acr.23926

323. Godeau D, Petit A, Richard I, Roquelaure Y, Descatha A. Return-to-work, disabilities and occupational health in the age of COVID-19. Scand J Work Environ Health. 2021;47(5):408-409. doi: 10.5271/sjweh.3960

324. Fajgenbaum DC, June CH. Cytokine storm. N Engl J Med. 2020;383(23):2255-2273. doi: 10.1056/NEJMra2026131

325. Vora SM, Lieberman J, Wu H. Inflammasome activation at the crux of severe COVID-19. Nat Rev Immunol. 2021;21(11):694-703. doi: 10.1038/s41577-021-00588-x

326. Ferreira AC, Soares VC, de Azevedo-Quintanilha IG, Dias SDSG, Fintelman-Rodrigues N, Sacramento CQ, et al. SARS-CoV-2 engages inflammasome and pyroptosis in human primary monocytes. Cell Death Discov. 2021;7(1):43. doi: 10.1038/s41420-021-00428-w

327. Zhao Y, Qin L, Zhang P, Li K, Liang L, Sun J, et al. Longitudinal COVID-19 profiling associates IL-1RA and IL-10 with disease severity and RANTES with mild disease. JCI Insight. 2020;5(13):e139834. doi: 10.1172/jci.insight.139834

328. Kyriakoulis KG, Kollias A, Poulakou G, Kyriakoulis IG, Trontzas IP, Charpidou A, et al. The effect of anakinra in hospitalized patients with COVID-19: An updated systematic review and meta-analysis. J Clin Med. 2021;10(19):4462. doi: 10.3390/jcm10194462

329. Barkas F, Filippas-Ntekouan S, Kosmidou M, Liberopoulos E, Liontos A, Milionis H. Anakinra in hospitalized non-intubated patients with coronavirus disease 2019: A systematic review and meta-analysis. Rheumatology (Oxford). 2021;60(12):5527-5537. doi: 10.1093/rheumatology/keab447

330. van de Veerdonk FL, Giamarellos-Bourboulis E, Pickkers P, Derde L, Leavis H, van Crevel R, et al. A guide to immunotherapy for COVID-19. Nat Med. 2022;28(1):39-50. doi: 10.1038/s41591-021-01643-9

331. Mehta P, Cron RQ, Hartwell J, Manson JJ, Tattersall RS. Silencing the cytokine storm: The use of intravenous anakinra in haemophagocytic lymphohistiocytosis or macrophage activation syndrome. Lancet Rheumatol. 2020;2(6):e358-e367. doi: 10.1016/S2665-9913(20)30096-5

332. Gilboa M, Bornstein G, Ben-Zvi I, Grossman C. Macrophage activation syndrome complicating rheumatic diseases in adults: Case-based review. Rheumatol Int. 2020;40(4):663-669. doi: 10.1007/s00296-019-04393-7

333. Ajeganova S, De Becker A, Schots R. Efficacy of high-dose anakinra in refractory macrophage activation syndrome in adult-onset Still’s disease: When dosage matters in overcoming secondary therapy resistance. Ther Adv Musculoskelet Dis. 2020;12: 1759720X20974858. doi: 10.1177/1759720X20974858

334. Monteagudo LA, Boothby A, Gertner E. Continuous intravenous anakinra infusion to calm the cytokine storm in macrophage activation syndrome. ACR Open Rheumatol. 2020;2(5):276-282. doi: 10.1002/acr2.11135

335. Thurner L, Fadle N, Bewarder M, Kos I, Regitz E, Thurner B, et al. Autoantibodies against Progranulin and IL-1 receptor antagonist due to immunogenic posttranslational isoforms contribute to hyperinflammation in critically ill COVID-19. bioRxiv. 2021.04.23.441188. doi: 10.1101/2021.04.23.441188

336. Pfeifer J, Thurner B, Kessel C, Fadle N, Kheiroddin P, Regitz E, et al. Autoantibodies against interleukin-1 receptor antagonist in multisystem inflammatory syndrome in children: A multicentre, retrospective, cohort study. Lancet Rheumatol. 2022;4(5):e329-e337. doi: 10.1016/S2665-9913(22)00064-9

337. Jarrell JA, Baker MC, Perugino CA, Liu H, Bloom MS, Maehara T, et al. Neutralizing anti-IL-1 receptor antagonist autoantibodies induce inflammatory and fibrotic mediators in IgG4-related disease. J Allergy Clin Immunol. 2022;149(1): 358-368. doi: 10.1016/j.jaci.2021.05.002

338. Smolen JS, Aletaha D, Bijlsma JW, Breedveld FC, Boumpas D, Burmester G, et al.; T2T Expert Committee. Treating rheumatoid arthritis to target: Recommendations of an international task force. Ann Rheum Dis. 2010;69(4):631-637. doi: 10.1136/ard.2009.123919

339. Roodenrijs NMT, Hamar A, Kedves M, Nagy G, van Laar JM, van der Heijde D, et al. Pharmacological and non-pharmacological therapeutic strategies in difficult-to-treat rheumatoid arthritis: A systematic literature review informing the EULAR recommendations for the management of difficult-to-treat rheumatoid arthritis. RMD Open. 2021;7(1):e001512. doi: 10.1136/rmdopen-2020-001512

340. Nagy G, Roodenrijs NMT, Welsing PMJ, Kedves M, Hamar A, van der Goes MC, et al. EULAR points to consider for the management of difficult-to-treat rheumatoid arthritis. Ann Rheum Dis. 2022;81(1):20-33. doi: 10.1136/annrheumdis-2021-220973

341. Yu KH, Chen HH, Cheng TT, Jan YJ, Weng MY, Lin YJ, et al. Consensus recommendations on managing the selected comorbidities including cardiovascular disease, osteoporosis, and interstitial lung disease in rheumatoid arthritis. Medicine (Baltimore). 2022;101(1):e28501. doi: 10.1097/MD.0000000000028501


Рецензия

Для цитирования:


Насонов Е.Л., Самсонов М.Ю. Роль интерлейкина 1 в развитии заболеваний человека: фокус на анакинре (рецепторном антагонисте ИЛ-1). Научно-практическая ревматология. 2022;60(3):280-298. https://doi.org/10.47360/1995-4484-2022-280-298

For citation:


Nasonov E.L., Samsonov M.Yu. The role of interleukin 1 in the development of human diseases: focus on Anakinra (IL-1 receptor antagonist). Rheumatology Science and Practice. 2022;60(3):280-298. (In Russ.) https://doi.org/10.47360/1995-4484-2022-280-298

Просмотров: 619


Creative Commons License
Контент доступен под лицензией Creative Commons Attribution 4.0 License.


ISSN 1995-4484 (Print)
ISSN 1995-4492 (Online)