Avascular necrosis as a part of post-COVID syndrome. Case reports
https://doi.org/10.47360/1995-4484-2022-420-426
Abstract
Coronavirus disease 2019 (COVID-19) can manifest with a wide range of extrapulmonary symptoms and have longterm consequences (so-called post-covid syndrome (PCS) or “long COVID-19”). Manifestations of PCS show a wide clinical spectrum and include cardiac, pulmonary, neurological, gastrointestinal, dermatological, mental symptoms, vascular thrombosis and avascular necrosis (AVN) of the bones.
We present our own observations of the development of bone’s AVN in 3 patients who underwent COVID-19 with bilateral lung disease, in whom after 4–6 months the first signs of AVN were noted and characterized by a progressive multifocal lesion, which was accompanied by an increase of C-reactive protein concentration.
The pathogenetic mechanisms of AVN development in the framework of PCS are discussed. The importance of conservative and surgical methods in the treatment of the disease are considered. Since the development of AVN of various localizations with a long latent period is possible after COVID-19, long-term monitoring of patients is required. Further study of the problem of PCS in general and AVN in particular is required.
About the Authors
T. V. Beketova
Central State Medical Academy of the Administrative Directorate of the President of the Russian Federation;
V.A. Nasonova Research Institute of Rheumatology;
Moscow Polytechnic University
Russian Federation
Competing Interests:
Russian Federation
Competing Interests:
121359, Moscow, Marshala Timoshenko str., 19, building 1A;
115522, Moscow, Kashirskoye Highway, 34A;
107023, Moscow, Bolshaya Semyonovskaya str., 38
N. O. Levina
Central State Medical Academy of the Administrative Directorate of the President of the Russian Federation
Russian Federation
Russian Federation
121359, Moscow, Marshala Timoshenko str., 19, building 1A
D. O. Ladygina
Central State Medical Academy of the Administrative Directorate of the President of the Russian Federation
Russian Federation
Russian Federation
121359, Moscow, Marshala Timoshenko str., 19, building 1A
V. V. Babak
V.A. Nasonova Research Institute of Rheumatology
Russian Federation
Russian Federation
115522, Moscow, Kashirskoye Highway, 34A
M. F. Beketova
Lomonosov Moscow State University
Russian Federation
Russian Federation
119991, Moscow, Leninskie Gory, 12
T. N. Krasnova
Lomonosov Moscow State University
Russian Federation
Russian Federation
119991, Moscow, Leninskie Gory, 12
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For citations:
Beketova T.V., Levina N.O., Ladygina D.O., Babak V.V., Beketova M.F., Krasnova T.N. Avascular necrosis as a part of post-COVID syndrome. Case reports. Rheumatology Science and Practice. 2022;60(4):420-426. (In Russ.) https://doi.org/10.47360/1995-4484-2022-420-426
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