Перспективы ингибиции интерлейкина-6 при ревматоидном артрите: олокизумаб (новые моноклональные антитела к ИЛ-6)
https://doi.org/10.47360/1995-4484-2022-505-518
Аннотация
Ревматоидный артрит (РА) – хроническое иммуновоспалительное ревматическое заболевание (ИВРЗ), проявляющееся прогрессирующей деструкцией суставов, системным воспалением внутренних органов и широким спектром коморбидных заболеваний, связанных с хроническим воспалением. В спектре цитокинов, принимающих участие в патогенезе РА и других ИВРЗ, большое внимание уделяется роли интерлейкина (ИЛ) 6. Внедрение в клиническую практику моноклональных антител (мАТ) – тоцилизумаба (ТЦЗ), а затем сарилумаба (САР), блокирующих клеточные эффекты этого цитокина, относится к числу крупнейших достижений в лечении ИВРЗ в начале XXI века. Особое внимание привлекают гуманизированные мАТ к ИЛ-6 – олокизумаб (ОКЗ), разработанные Российской компанией «Р-ФАРМ» в рамках лицензионного соглашения с UCB Pharma. В обзоре рассматриваются новые данные, касающиеся эффективности и безопасности ОКЗ при РА и перспективы применения ОКЗ в ревматологии.
Об авторах
Е. Л. Насонов
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»; ФГАОУ ВО «Первый Московский государственный медицинский университет имени И.М. Сеченова» Минздрава России (Сеченовский
Университет)
Россия
Россия
11552, Москва, Каширское шоссе, 34а; 119991, Москва, ул. Трубецкая, 8, стр. 2
Е. Файст
Отделение ревматологии Клиники Гелиос Фогельсанг-Гоммерн, партнер по сотрудничеству Магдебургского университета имени Отто фон Герике
Германия
Германия
39245, Гоммерн, Софи-в.- Беттихер-Штрассе, 1
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Рецензия
Для цитирования:
Насонов Е.Л., Файст Е. Перспективы ингибиции интерлейкина-6 при ревматоидном артрите: олокизумаб (новые моноклональные антитела к ИЛ-6). Научно-практическая ревматология. 2022;60(5):505-518. https://doi.org/10.47360/1995-4484-2022-505-518
For citation:
Nasonov E.L., Feist E. The prospects of interleukin-6 inhibition in rheumatoid arthritis: Olokizumab (novel monoclonal antibodies to IL-6). Rheumatology Science and Practice. 2022;60(5):505-518. (In Russ.) https://doi.org/10.47360/1995-4484-2022-505-518
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