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Научно-практическая ревматология

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Аваскулярный некроз костной ткани: определение, эпидемиология, виды, факторы риска, патогенез заболевания. Аналитический обзор литературы

https://doi.org/10.47360/1995-4484-2023-220-235

Полный текст:

Аннотация

Аваскулярный некроз (АН) костной ткани является распространенной патологией, которой страдают люди любого возраста, чаще молодые и трудоспособные. Заболевание приводит к быстрому разрушению субхондральной кости и коллапсу с последующим развитием вторичного остеоартрита (ОА) пораженного сустава.

Целью данной обзорной статьи является представление накопленных знаний о распространенности АН, наиболее частых его локализациях, факторах риска и патогенезе заболевания. Поскольку в большинстве мировых источников литературы представлены знания об отдельных звеньях патогенеза АН, в этой статье выполнен анализ всех известных путей развития заболевания – от начала ишемии до коллапса и развития вторичного ОА, и патогенез представлен в хронологическом порядке. По результатам статьи предложено определение термина АН и выделены стадии развития заболевания, наиболее перспективные для консервативных методов лечения.

Об авторах

В. Е. Бялик
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»
Россия

115522, Москва, Каширское шоссе, 34а



М. А. Макаров
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»
Россия

115522, Москва, Каширское шоссе, 34а



Е. И. Бялик
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»; ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России
Россия

115522, Москва, Каширское шоссе, 34а;
125993, Москва, ул. Баррикадная, 2/1, стр. 1



С. А. Макаров
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»
Россия

115522, Москва, Каширское шоссе, 34а



А. Е. Каратеев
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»
Россия

115522, Москва, Каширское шоссе, 34а



В. А. Нестеренко
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»
Россия

115522, Москва, Каширское шоссе, 34а



А. А. Черникова
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»
Россия

115522, Москва, Каширское шоссе, 34а



Д. В. Капитонов
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»
Россия

115522, Москва, Каширское шоссе, 34а



А. И. Горелова
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»
Россия

115522, Москва, Каширское шоссе, 34а



Список литературы

1. Cooper C, Steinbuch M, Stevenson R, Miday R, Watts NB. The epidemiology of osteonecrosis: Findings from the GPRD and THIN databases in the UK. Osteoporos Int. 2009;21(4):569-577. doi: 10.1007/s00198-009-1003-1

2. Bergman J, Nordström A, Nordström P. Epidemiology of osteonecrosis among older adults in Sweden. Osteoporos Int. 2019;30(5):965-973 doi: 10.1007/s00198-018-04826-2

3. Assouline-Dayan Y, Chang C, Greenspan A. Pathogenesis and natural history of osteonecrosis. Semin Arthritis Rheum. 2002;32(2):94-124. doi: 10.1053/sarh.2002.33724b

4. Торгашин АН, Родионова СС, Шумский АА, Макаров МА, Торгашина АВ, Ахтямов ИФ, и др. Лечение асептического некроза головки бедренной кости. Клинические рекомендации. Научно-практическая ревматология. 2020;58(6):637-645. doi: 10.47360/1995-4484-2020-637-645

5. Ильиных ЕВ, Барскова ВГ, Лидов ПИ, Насонов ЕЛ. Остеонекроз. Часть 1. Факторы риска и патогенез. Современная ревматология. 2013;1:17-24. doi: 10.14412/1996-7012-2013-2362

6. Шостак НА, Демидова НА, Кондрашов АА, Андрияшкина ДЮ, Ратьев АП, Аветисян ГР, и др. Остеонекроз головки бедренной кости, не связанный с травмой: патогенетические аспекты, клиническая и инструментальная картина (часть 1). Лечебное дело. 2021;2:4-16. doi: 10.24412/2071-5315-2021-12326

7. Chang C, Greenspan A, Gershwin ME. The pathogenesis, diagnosis and clinical manifestations of steroid-induced osteonecrosis. J Autoimmun. 2020;110:102460. doi: 10.1016/j.jaut.2020.102460

8. Powell C, Chang C, Gershwin ME. Current concepts on the pathogenesis and natural history of steroid-induced osteonecrosis. Clin Rev Allergy Immunol. 2010;41(1):102-113. doi: 10.1007/s12016-010-8217-z

9. Антонов АВ, Воловик ВЕ. Асептический некроз головки бедренной кости: этиопатогенез, ранняя диагностика и лечение. Acta biomedica scientifica. 2019;4(6):60-67. doi: 10.29413/ABS.2019-4.6.9

10. Seamon J, Keller T, Saleh J, Cui Q. The pathogenesis of nontraumatic osteonecrosis. Arthritis. 2012;2012:601763. doi: 10.1155/2012/601763

11. Коваленко АН, Ахтямов ИФ. Этиология и патогенез асептического некроза головки бедренной кости. Гений ортопедии. 2010;2:138-144. [Kovalenko AN, Akhtiamov IF. Etiology and pathogenesis of femoral head aseptic necrosis. Genij Ortopedii. 2010;2:138-144 (In Russ.).

12. Petrigliano FA, Lieberman JR. Osteonecrosis of the hip: Novel approaches to evaluation and treatment. Clin Orthop Relat Res. 2007;465:53-62. doi: 10.1097/BLO.0b013e3181591c92

13. Dima A, Pedersen AB, Pedersen L, Baicus C, Thomsen RW. Association of common comorbidities with osteonecrosis: A nationwide population-based case–control study in Denmark. BMJ Open. 2018;8:1-6. doi: 10.1136/bmjopen-2017-020680

14. Arbab D, König DP. Atraumatic femoral head necrosis in adults – Epidemiology, etiology, diagnosis and treatment. Dtsch Arztebl Int. 2016;113:31-38. doi: 10.3238/arztebl.2016.0031

15. Zhao DW, Yu M, Hu K, Wang W, Yang L, Wang BJ, et al. Prevalence of nontraumatic osteonecrosis of the femoral head and its associated risk factors in the chinese population: Results from a nationally representative survey. Chin Med J (Engl). 2015;128(21):2843-2850. doi: 10.4103/0366-6999.168017

16. Ikeuchi K, Hasegawa Y, Seki T, Takegami Y, Amano T, Ishiguro N. Epidemiology of nontraumatic osteonecrosis of the femoral head in Japan. Mod Rheumatol. 2015;25(2):278-281. doi: 10.3109/14397595.2014.932038

17. Kang JS, Park S, Song JH, Jung YY, Cho MR, Rhyu KH. Prevalence of osteonecrosis of the femoral head: A nationwide epidemiologic analysis in Korea. J Arthroplasty. 2009;24(8):1178-1183. doi: 10.1016/j.arth.2009.05.022

18. Мустафин РН. Аваскулярный некроз головки бедренной кости в Республике Башкортостан (клинико-эпидемиологическое исследование). Креативная хирургия и онкология. 2020;10(2):100-107. doi: 10.24060/2076-3093-2020-10-2-100-107

19. Massari L, Fini M, Cadossi R, Setti S, Traina GC. Biophysical stimulation in osteonecrosis of the femoral head. IJO. 2009;43(1):17-21. doi: 10.4103/0019-5413.45319

20. Барскова ВГ, Ильиных ЕВ, Смирнов АВ, Владимиров СА, Мирович ОВ, Божьева ЛА, и др. Остеонекроз. Часть 2. Клиника и диагностика аваскулярного некроза. Современная ревматология. 2013;2:32-36. doi: 10.14412/1996-7012-2013-2378

21. Badar T, Shetty A, Bueso-Ramos C, Cortes J, Konopleva M, Borthakur G, et al. Bone marrow necrosis in acute leukemia: Clinical characteristic and outcome. Am J Hematol. 2015;90(9):769-773. doi: 10.1002/ajh.24074

22. Umans H, Haramati N, Flusser G. The diagnostic role of gadolinium enhanced MRI in distinguishing between acute medullary bone infarct and osteomyelitis. Magnetic Resonance Imaging. 2000;18:255-262. doi: 10.1016/s0730-725x(99)00137-x

23. Swiontkowski MF, Winquist RA, Hansen ST. Fractures of the femoral neck in patients between the ages of twelve and forty-nine years. J Bone Joint Surg Am. 1984;66:837-846. doi: 10.2106/00004623-198466060-00003

24. Protzman RR, Burkhalter WE. Femoral neck fractures in young adults. J Bone Joint Surg Am. 1976;58:689-695.

25. Kofoed H. Femoral neck fractures in young adults. Injury. 1982;14:146-150. doi: 10.1016/0020-1383(82)90049-3

26. Ghayoumi P, Kandemir U, Morshed S. Evidence based update: Open versus closed reduction. Injury. 2015;46:467-473. doi: 10.1016/j.injury.2014.10.011

27. Adelaar RS, Madrian JR. Avascular necrosis of the talus. Orthop Clin North Am. 2004;35:383-395. doi: 10.1016/j.ocl.2004.02.010

28. Dodd A, Lefaivre KA. Outcomes of talar neck fractures: A systematic review and meta-analysis. J Orthop Trauma. 2015;29:210-215. doi: 10.1097/BOT.0000000000000297

29. Beeres FJP, Hallensleben NDL, Rhemrev SJ, Goslings JC, Oehme F, Meylaerts SAG, et al. Plate fixation of the proximal humerus: An international multicentre comparative study of post-operative complications. Arch Orthop Trauma Surg. 2017;137(12):1685-1692. doi: 10.1007/s00402-017-2790-z

30. Falez F, Papalia M, Greco A, Teti A, Favetti F, Panegrossi G, et al. Minimally invasive plate osteosynthesis in proximal humeral fractures: One-year results of a prospective multicenter study. Int Orthop. 2016;40(3):579-585. doi: 10.1007/s00264-015-3069-z

31. Neviaser AS, Hettrich CM, Dines JS, Lorich DG. Rate of avascular necrosis following proximal humerus fractures treated with a lateral locking plate and endosteal implant. Arch Orthop Trauma Surg. 2011;131:1617-1622. doi: 10.1007/s00402-011-1366-6

32. Belayneh R, Lott A, Haglin J, Konda S, Zuckerman JD, Egol KA. Osteonecrosis after surgically repaired proximal humerus fractures is a predictor of poor outcomes. J Orthop Trauma. 2018;32(10):e387-e393. doi: 10.1097/BOT.0000000000001260

33. Brahme SK, Fox JM, Ferkel RD, Friedman MJ, Flannigan BD, Resnick DL. Osteonecrosis of the knee after arthroscopic surgery: Diagnosis with MR imaging. Radiology. 1991;178(3):851-853. doi: 10.1148/radiology.178.3.1994431

34. Meringolo R, Navarra M, Mosca M, Ponziani L, Di Caprio F. Postarthroscopy osteonecrosis of the knee: Current concepts. Joints. 2017;5(4):229-236. doi: 10.1055/s-0037-1608666

35. Santori N, Condello V, Adriani E, Mariani PP. Osteonecrosis after arthroscopic medial meniscectomy. Arthroscopy. 1995;11(02):220-224. doi: 10.1016/0749-8063(95)90071-3

36. Pruès-Latour V, Bonvin JC, Fritschy D. Nine cases of osteonecrosis in elderly patients following arthroscopic meniscectomy. Knee Surg Sports Traumatol Arthrosc. 1998;6(03):142-147. doi: 10.1007/s001670050090

37. Cetik O, Cift H, Comert B, Cirpar M. Risk of osteonecrosis of the femoral condyle after arthroscopic chondroplasty using radiofrequency: A prospective clinical series. Knee Surg Sports Traumatol Arthrosc. 2008;17(1):24-29. doi: 10.1007/s00167-008-0604-0

38. Pape D, Seil R, Anagnostakos K, Kohn D. Postarthroscopic osteonecrosis of the knee. Arthroscopy. 2007;23(04):428-438. doi: 10.1007/s00132-008-1303-8

39. Yao L, Stanczak J, Boutin RD. Presumptive subarticular stress reactions of the knee: MRI detection and association with meniscal tear patterns. Skeletal Radiol. 2004;33(05):260-264. doi: 10.1007/s00256-004-0751-4

40. Fukuda Y, Takai S, Yoshino N, Murase K, Tsutsumi S, Ikeuchi K, et al. Impact load transmission of the knee joint-influence of leg alignment and the role of meniscus and articular cartilage. Clin Biomech (Bristol, Avon). 2000;15(7):516-521. doi: 10.1016/s0268-0033(00)00013-9

41. Jones RS, Keene GC, Learmonth DJ, Bickerstaff D, Nawana NS, Costi JJ, et al. Direct measurement of hoop strains in the intact and torn human medial meniscus. Clin Biomech (Bristol, Avon). 1996;11(5):295-300. doi: 10.1016/0268-0033(96)00003-4

42. Rozbruch SR, Wickiewicz TL, DiCarlo EF, Potter HG. Osteonecrosis of the knee following arthroscopic laser meniscectomy. Arthroscopy. 1996;12(02):245-250. doi: 10.1016/s0749-8063(96)90022-5

43. Kerachian MA, Harvey EJ, Cournoyer D, Chow TYK, Seguin C. Mini-review avascular necrosis of the femoral head: Vascular hypotheses. Endothelium. 2006;13:237-244. doi: 10.1080/10623320600904211

44. Wang A, Ren M, Wang J. The pathogenesis of steroid-induced osteonecrosis of the femoral head: A systematic review of the literature. Gene. 2018;671:103-109. doi: 10.1016/j.gene.2018.05.091

45. Guerado E, Caso E. The physiopathology of avascular necrosis of the femoral head: An update. Int J Care Injured. 2016;47S6:S16-S26. doi: 10.1016/S0020-1383(16)30835-X

46. Weinstein RS. Glucocorticoid-induced osteonecrosis. Endocrine. 2012;41:183-190. doi: 10.1007/s12020-011-9580-0

47. Mont MA, Pivec R, Banerjee S, Issa K, Elmallah RK, Jones LC. High-dose corticosteroid use and risk of hip osteonecrosis: Meta-analysis and systematic literature review. J Arthroplasty. 2015;30(9):1506-1512.e5. doi: 10.1016/j.arth.2015.03.036

48. Weldon D. The effects of corticosteroids on bone: Osteonecrosis (avascular necrosis of the bone). Ann Allergy Asthma Immunol. 2009;103:91-98. doi: 10.1016/S1081-1206(10)60159-7

49. Matsuo K, Hirohata T, Sugioka Y, Ikeda M, Fukuda A. Influence of alcohol intake, cigarette smoking, and occupational status on idiopathic osteonecrosis of the femoral head. Clin Orthop Relat Res. 1988;234:115-123. doi: 10.1097/00003086-198809000-00021

50. Jacobs B. Epidemiology of traumatic and nontraumatic osteonecrosis. Clin Orthop Relat Res. 1978;130:51-67. doi: 10.1097/00003086-197801000-00005

51. Moskal JT, Topping RE, Franklin LL. Hypercholesterolemia: An association with osteonecrosis of the femoral head. Am J Orthop. 1997;26:609-612.

52. Matos MA, Alencar RW, Matos SS. Avascular necrosis of the femoral head in HIV infected patients. Braz J Infect Dis. 2007;11:31-34. doi: 10.1590/s1413-86702007000100009

53. Nagasawa K, Tada Y, Koarada S, Horiuchi T, Tsukamoto H, Murai K, et al. Very early development of steroid-associated osteonecrosis of femoral head in systemic lupus erythematosus: Prospective study by MRI. Lupus. 2005;14(5):385-390. doi: 10.1191/0961203305lu2103oa

54. Glueck CJ, Freiberg RA, Boppana S, Wang P. Thrombophilia, hypofibrinolysis, the eNOS T-786C polymorphism, and multifocal osteonecrosis. J Bone Joint Surg Am Vol. 2008;90(10):2220-2229. doi: 10.2106/jbjs.g.00616

55. Korompilias AV, Ortel TL, Urbaniak JR. Coagulation abnormalities in patients with hip osteonecrosis. Orthop Clin North Am. 2004;35(3):265-271. doi: 10.1016/j.ocl.2004.02.004

56. Zalavras CG, Vartholomatos G, Dokou E, Malizos K. Genetic background of osteonecrosis: Associated with thrombophilic mutations? Clin Orthop Relat Res. 2004;422:251-255. doi: 10.1097/01.blo.0000127921.13253.e3

57. Glueck CJ, Freiberg R, Tracy T, Stroop D, Wang P. Thrombophilia and hypofibrinolysis: Pathophysiologies of osteonecrosis. Clin Orthop Relat Res. 1997;334:43-56. doi: 10.1097/00003086-199701000-00007

58. Styles L, Vichinsky E. Core decompression in avascular necrosis of the hip in sickle-cell disease. Am J Hematol. 1996;52:103-107. doi: 10.1002/(SICI)1096-8652(199606)52:2<103::AID-AJH6>3.0.CO;2-Y

59. Hammer M, Geier KA, Aksoy S, Reynolds HM. Perioperative care for patients with sickle cell who are undergoing total hip replacement as treatment for osteonecrosis. Orthop Nurs. 2003;22(6):384-397. doi: 10.1097/00006416-200311000-00004

60. Abu-Shakra M, Buskila D, Shoenfeld Y. Osteonecrosis in patients with SLE. Clin Rev Allergy Immunol. 2003;25(1):13-24. doi: 10.1385/criai:25:1:13

61. Qijiao W, Meng Z, Jianwen L, Shengli Z, Fei G, He L, et al. Antiphospholipid antibodies and osteonecrosis in systemic lupus erythematosus: A meta-analysis. Expert Rev Clin Immunol. 2021;17(8):923-932. doi: 10.1080/1744666X.2021.1925109

62. Gladman DD, Dhillon N, Su J, Urowitz MB. Osteonecrosis in SLE: Prevalence, patterns, outcomes and predictors. Lupus. 2017;27(1):76-81. doi: 10.1177/0961203317711012

63. Zizic TM, Marcoux C, Hungerford DS, Dancereau JV, Stevens MB. Corticosteroid therapy associated with ischemic necrosis of bone in systemic lupus erythematosus. Am J Med. 1985;79:596-604. doi: 10.1016/0002-9343(85)90057-9

64. Rascu AK, Manger HG, Kraetsch JR, Kalden J, Manger B. Osteonecrosis in systemic lupus erythematosus, steroid-induced or a lupus-dependent manifestation? Lupus. 1996;5:323-327. doi: 10.1177/096120339600500414

65. Hussein S, Suitner M, Béland-Bonenfant S, Baril-Dionne A, Vandermeer B, Santesso N, et al. Monitoring of osteonecrosis in systemic lupus erythematosus: A systematic review and metaanalysis. J Rheumatol. 2018;45(10):1462-1476. doi: 10.3899/jrheum.170837

66. Zhu KK, Xu WD, Pan HF, Zhang M, Ni J, Ge FY, et al. The risk factors of avascular necrosis in patients with systemic lupus erythematosus: A meta-analysis. Inflammation. 2014;37(5):1852-1864. doi: 10.1007/s10753-014-9917-y

67. Tektonidou MG, Moutsopoulos HM. Immunologic factors in the pathogenesis of osteonecrosis. Orthop Clin North Am. 2004;35(3):259-263. doi: 10.1016/j.ocl.2004.02.003

68. Asherson RA, Jungers P, Liote F. Ischaemic necrosis of bone associated with the “lupus anticoagulant” and antibodies to cardiolipin. Proceedings of the XIVth International Congress of Rheumatology (Sydney, Australia, May 19–25). 1985:373.

69. Asherson RA, Lioté F, Page B, Meyer O, Buchanan N, Khamashta MA, et al. Avascular necrosis of bone and antiphospholipid antibodies in systemic lupus erythematosus. J Rheumatol. 1993;20(2):284-288.

70. Korompilias AV, Gilkeson GS, Ortel TL, Seaber AV, Urbaniak JR. Anticardiolipin antibodies and osteonecrosis of the femoral head. Clin Orthop. 1997;345:174-180. doi: 10.1097/00003086-199712000-00025

71. Miller KD, Masur H, Jones EC, Joe GO, Rick ME, Kelly GG, et al. High prevalence of osteonecrosis of the femoral head in HIV-infected adults. Ann Intern Med. 2002;137(1):17-25. doi: 10.7326/0003-4819-137-1-200207020-00008

72. Alarcón-Segovia D, Delezé M, Oria CV, Sánchez-Guerrero J, Gómez-Pacheco L, Cabiedes J, et al. Antiphospholipid antibodies and the antiphospholipid syndrome in systemic lupus erythematosus. A prospective analysis of 500 consecutive patients. Medicine (Baltimore). 1989;68(6):353-365. doi: 10.1097/00005792-198911000-00003

73. Petri M. Muscosceletal complications of systemic lupus erythematosus in the Hopkins Lupus Cohort: An update. Arthritis Care Res. 1995;8(3):137-145. doi: 10.1002/art.1790080305

74. Abraham RR, Meyerhoff JO. Does vasculitis alone cause AVN? A review of literature. Rheumatol Int. 2012;33(10):2671-2673. doi: 10.1007/s00296-012-2467-4

75. Jager M, Thorey F, Wild A, Voede M, Krauspe R. Osteonekrosen bei Morbus Adamantiades-Behcet: Diagnostik, Therapie und Verlauf. Zeitschrift For Rheumatologie. 2003;62(4):390-394. doi: 10.1007/s00393-003-0473-3

76. Atas N, Bitik B, Varan O, Babaoglu H, Tufan A, Haznedaroglu S, et al. Clinical characteristics of avascular necrosis in patients with Behçet disease: A case series and literature review. Rheumatol Int. 2019;39(1):153-159. doi: 10.1007/s00296-018-4224-9

77. Zabinski SJ, Sculco TP, Dicarlo EF, Rivelis M. Osteonecrosis in the rheumatoid femoral head. J Rheumatol. 1998;25(9):1674-1680.

78. Van Vugt RM, Sijbrandij ES, Bijlsma JW. Magnetic resonance imaging of the femoral head to detect avascular necrosis in active rheumatoid arthritis treated with methylprednisolone pulse therapy. Scand J Rheumatol. 1996;25(2):74-76. doi: 10.3109/03009749609069211

79. Boettcher WG, Bonfiglio M, Hamilton HR, Sheets RF, Smith K. Nontraumatic necrosis of the femoral head; Part 1 – Relation of altered homeostasis to etiology. J Bone Joint Surg. 1970;52A:311.

80. DeSeze S, Mazabraud A. La necrose parcellaire de la tete femorale. Rev Rhum. 1971;38:l.

81. Martinez-Cordero E. Avascular necrosis of bone in systemic sclerosis. Clin Rheumatol. 1992;11(4):443-444. doi: 10.1007/bf02207216

82. Wilde AH, Mankin HJ, Rodman GP. Avascular necrosis of the femoral head in scleroderma. Arthritis Rheum. 1970;13(4):445-447. doi: 10.1002/art.1780130414

83. Shigemura T, Nakamura J, Kishida S, Harada Y, Ohtori S, Kamikawa K, et al. Incidence of osteonecrosis associated with corticosteroid therapy among different underlying diseases: Prospective MRI study. Rheumatology (Oxford). 2011;50(11):2023-2028. doi: 10.1093/rheumatology/ker277

84. Tian L, Baek S-H, Jang J, Kim S-Y. Imbalanced bone turnover markers and low bone mineral density in patients with osteonecrosis of the femoral head. Int Orthop. 2018;42(7):1545-1549. doi: 10.1007/s00264-018-3902-2

85. Akamatsu Y, Mitsugi N, Hayashi T, Kobayashi H, Saito T. Low bone mineral density is associated with the onset of spontaneous osteonecrosis of the knee. Acta Orthopaedica. 2012;83(3):249-255. doi: 10.3109/17453674.2012.684139

86. Namiranian P, Razavi SZE, Karimi M, Ayati MH. Avascular necrosis in patients recovering from COVID-19. Am J Med Sci. 2021;362(3):331-332. doi: 10.1016/j.amjms.2021.05.018

87. Hajra A, Mathai SV, Ball S, Bandyopadhyay D, Veyseh M, Chakraborty S, et al. Management of thrombotic complications in COVID-19: An update. Drugs. 2020;80(15):1553-1562. doi: 10.1007/s40265-020-01377-x

88. Anka AU, Tahir MI, Abubakar SD, Alsabbagh M, Zian Z, Hamedifar H, et al. Coronavirus disease 2019 (COVID-19): An overview of the immunopathology, serological diagnosis and management. Scand J Immunol. 2021;93(4):e12998. doi: 10.1111/sji.12998

89. Dutch COVID & Thrombosis Coalition; Kaptein FHJ, Stals MAM, Grootenboers M, Braken SJE, Burggraaf JLI, et al. Incidence of thrombotic complications and overall survival in hospitalized patients with COVID-19 in the second and first wave. Thromb Res. 2021;199:143-148. doi: 10.1016/j.thromres.2020.12.019

90. van Paassen J, Vos JS, Hoekstra EM, Neumann KMI, Boot PC, Arbous SM. Corticosteroid use in COVID-19 patients: A systematic review and meta-analysis on clinical outcomes. Crit Care. 2020;24(1):696. doi: 10.1186/s13054-020-03400-9

91. Cano EJ, Fonseca Fuentes X, Corsini Campioli C, O’Horo JC, Abu Saleh O, Odeyemi Y, et al. Impact of corticosteroids in coronavirus disease 2019 outcomes: Systematic review and meta-analysis. Chest. 2021;159(3):1019-1040. doi: 10.1016/j.chest.2020.10.054

92. Agarwala SR. Avascular necrosis as a part of ‘long COVID-19. BMJ. 2021;14:e242101. doi: 10.1136/bcr-2021-24210

93. Sulewski A, Sieroń D, Szyluk K, Dąbrowski M, Kubaszewski Ł, Lukoszek D, et al. Avascular necrosis bone complication after active COVID-19 infection: Preliminary results. Medicina (Kaunas). 2021;57(12):1311. doi: 10.3390/medicina57121311

94. Angulo-Ardoy M, Ureña-Aguilera Á. Knee osteonecrosis after COVID-19. Fam Pract. 2021;38(Suppl 1):45-47. doi: 10.1093/fampra/cmab063

95. Панин МА, Петросян АС, Хаджихараламбус КХ, Бойко АВ. Остеонекроз головки бедренной кости после COVID-19: серия клинических наблюдений. Травматология и ортопедия России. 2022;28(1):110-117. doi: 10.17816/2311-2905-1687

96. Баракат МФ, Мельцер РИ. Асептический некроз костей как осложнение ковидной инфекции. Sciences of Europe. 2022;89:23-25.

97. Shetty GM. Double trouble – COVID-19 and the widespread use of corticosteroids: Are we staring at an osteonecrosis epidemic? Indian J Orthop. 2022;56(2):226-236. doi: 10.1007/s43465-021-00546-8

98. Wenlong Li. General recommendation for assessment and management on the risk of glucocorticoid-induced osteonecrosis in patients with COVID-19. J Orthop Translat. 2021;31:1-9. doi: 10.1016/j.jot.2021.09.005

99. Zhang B, Zhang S. Corticosteroid-induced osteonecrosis in COVID-19: A call for caution. J Bone Miner Res. 2020;35(9):1828-1829. doi: 10.1002/JBMR.4136

100. Snowden GT, Clement ND, Zhang S, Xue Q, Simpson AHRW. Orthopaedic long COVID – The unknown unknowns. Are we facing a pandemic of avascular necrosis following COVID-19? Bone Joint Res. 2022;11(1):10-11. doi: 10.1302/2046-3758.111.BJR-2021-0505

101. Marston SB, Gillingham K, Bailey RF, Cheng EY. Osteonecrosis of the femoral head after solid organ transplantation: a prospective study. J Bone Joint Surg Am. 2002;84-A:2145-2151. doi: 10.2106/00004623-200212000-00004

102. Schoch OD, Speich R, Schmid C, Tschopp O, Russi EW, Weder W, et al. Osteonecrosis after lung transplantation: Cystic fibrosis as a potential risk factor. Transplantation. 2000;69(8):1629-1632. doi: 10.1097/00007890-200004270-00018

103. Lieberman JR, Roth KM, Elsissy P, Dorey FJ, Kobashigawa JA. Symptomatic osteonecrosis of the hip and knee after cardiac transplantation. J Arthroplasty. 2008;23:90-96. doi: 10.1016/j.arth.2007.01.006

104. Jeon HJ, Kim H, Yang J. Bone disease in post-transplant patients. Curr Opin Endocrinol Diabetes Obes. 2015;22(6):452-458. doi: 10.1097/med.0000000000000196

105. Monier P, McKown K, Bronze MS. Osteonecrosis complicating highly active antiretroviral therapy in patients infected with human immunodeficiency virus. Clin Infect Dis. 2000;31(6):1488-1492. doi: 10.1086/317503

106. Permpalung N, Ungprasert P, Summachiwakij S, Leeaphorn N, Knight EL. Protease inhibitors and avascular necrosis: A systematic review and meta-analysis. Int J Antimicrob Agents. 2014;44(2): 93-95. doi: 10.1016/j.ijantimicag.2014.02

107. Guggenbuhl P, Grosbois B, Chalès G. Gaucher disease. Joint Bone Spine. 2008;75(2):116-124. doi: 10.1016/j.jbspin.2007.06.006

108. Hughes D, Mikosch P, Belmatoug N, Carubbi F, Cox T, Goker-Alpan O, et al. Gaucher disease in bone: From pathophysiology to practice. J Bone Miner Res. 2019;34(6):996-1013. doi: 10.1002/jbmr.3734

109. Sharareh B, Schwarzkopf R. Dysbaric osteonecrosis. Clin J Sport Med. 2015;25(2):153-161. doi: 10.1097/jsm.0000000000000093

110. Barratt DM, Harch PG, Van Meter K. Decompression illness in divers: A review of the literature. Neurologist. 2002;8:186-202. doi: 10.1097/00127893-200205000-00005

111. Spira A. Diving and marine medicine review part II: Diving diseases. J Travel Med. 1999;6:180-198. doi: 10.1111/j.1708-8305.1999.tb00857.x

112. Lavernia CJ, Sierra RJ, Grieco FR. Osteonecrosis of the femoral head. J Am Acad Orthop Surg. 1999;7:250-261. doi: 10.5435/00124635-199907000-00005

113. Pfeifer W. A case of unusual form and origin of bilateral symmetrical osteonecrosis of the femoral & humeral heads. Fortschr Geb Rontgenstr Nuklearmed. 1957;86:346-349.

114. Wood TJ, Hoppe DJ, Winemaker M, Adili A. Bilateral osteonecrosis of the femoral head during pregnancy following two corticosteroid injections: A case report and review of the literature. Cureus. 2016;8(4):e556. doi: 10.7759/cureus.55

115. Turgay T, Aydeniz A. Avascular necrosis of the bilateral femoral head with pregnancy: A case report. Agri. 2020;32(4):228-231. doi: 10.5505/agri.2018.59480

116. Hasegawa Y, Iwase T, Iwasada S, Kitamura S, Iwata H. Osteonecrosis of the femoral head associated with pregnancy. Arch Orthop Trauma Surg. 1999;119(1-2):112-114. doi: 10.1007/s004020050370

117. Lespasio MJ, Sodhi N, Mont MA. Osteonecrosis of the hip: A primer. Perm J. 2019;23:18-100. doi: 10.7812/tpp/18-100

118. Zizic TM. Osteonecrosis. Curr Opin Rheum. 1991;3:481-489. doi: 10.1097/00002281-199106000-00023

119. Aaron RK, Voisinet A, Racine J, Ali Y, Feller ER. Corticosteroid-associated avascular necrosis: Dose relationships and early diagnosis. Ann N Y Acad Sci. 2011;1240:38-46. doi: 10.1111/j.1749-6632.2011.06218.x

120. Chandler F. Coronary disease of the hip. J Int Coll Surg. 1949;11:34-36. doi: 10.1097/00003086-200105000-00002

121. Bauer TW, Stulberg BN. The histology of osteonecrosis and its distinction from histologic artifacts. In: Bone Circulation and Vascularization in Normal and Pathological Conditions. 1993;283-292.

122. James J, Steijn-Myagkaya GL. Death of osteocytes. Electron microscopy after in vitro ischaemia. J Bone Joint Surg Br. 1986;68:620-624. doi: 10.1302/0301-620X.68B4.3733842

123. Jones JP, McCarty D. Osteonecrosis. In: Arthritis and Allied Conditions. 1985;1356-1373.

124. Kenzora JE. Osteonecrosis. In: Textbook of rheumatology. Philadelphia:WB Saunders;1981:1755-1782.

125. Imhof H, Breitenseher M, Trattnig S, Kramer J, Hofmann S, Plenk H, et al. Imaging of avascular necrosis of bone. Eur Radiol. 1997;7(2):180-186. doi: 10.1007/s003300050131

126. Utting JC, Robins SP, Brandao-Burch A, Orriss IR, Behar J, Arnett TR. Hypoxia inhibits the growth, differentiation and bone-forming capacity of rat osteoblasts. Exp Cell Res. 2006;312(10):1693-1702. doi: 10.1016/j.yexcr.2006.02.007

127. Kim TH, Hong JM, Oh B, Cho YS, Lee JY, Kim HL, et al. Genetic association study of polymorphisms in the catalase gene with the risk of osteonecrosis of the femoral head in the Korean population. Osteoarthritis Cartilage. 2008;16(9):1060-1066. doi: 10.1016/j.joca.2008.02.004

128. Ichiseki T, Ueda Y, Katsuda S, Kitamura K, Kaneuji A, Matsumoto T. Oxidative stress by glutathione depletion induces osteonecrosis in rats. Rheumatology (Oxford). 2006;45(3):287-290. doi: 10.1093/rheumatology/kei149

129. Laroche M. Intraosseous circulation from physiology to disease. Joint Bone Spine. 2002;69(3):262-269. doi: 10.1016/s1297-319x(02)00391-3

130. Parfitt AM. The mechanism of coupling: A role for the vasculature. Bone. 2000;26:319-323. doi: 10.1016/S8756-3282(00)80937-0

131. Phemister DB. Changes in bones and joints resulting from interruption of circulation. Arch Surg. 1940;41(2):436-472. doi: 10.1001/archsurg.1940.01210020234023

132. Saito S, Ohzono K, Ono K. Early arteriopathy and postulated pathogenesis of osteonecrosis of the femoral head. The intracapital arterioles. Clin Orthop Relat Res. 1992;277:98-110. doi: 10.1097/00003086-199204000-00012

133. Korompilias AV, Gilkeson GS, Seaber AV, Urbaniak JR. Hemorrhage and thrombus formation in early experimental osteonecrosis. Clin Orthop Relat Res. 2001;386:11-18. doi: 10.1097/00003086-200105000-00003

134. Matsui M, Saito S, Ohzono K, Sugano N, Saito M, Takaoka K, et al. Experimental steroid-induced osteonecrosis in adult rabbits with hypersensitivity vasculitis. Clin Orthop Relat Res. 1992;277:61-72.

135. Hirano K, Tsutsui H, Sugioka Y, Sueishi K. Histopathologic alterations of retinacular vessels and osteonecrosis. Clin Orthop Relat Res. 1997;342:192-204. doi: 10.1097/00003086-199709000-00027

136. Starklint H, Lausten GS, Arnoldi CC. Microvascular obstruction in avascular necrosis. Immunohistochemistry of 14 femoral heads. Acta Orthop Scand. 1995;66:9-12. doi: 10.3109/17453679508994629

137. Hungerford DS. Pathogenetic considerations in ischemic necrosis of bone. Can J Surg. 1981;24(6):583-590.

138. Stern B, Glimcher MJ, Goldhaber P. The effect of various oxygen tensions on the synthesis and degradation of bone collagen in tissue culture. Proc Soc Exp Biol Med. 1966;121:869-872. doi: 10.3181/00379727-121-30911

139. Arlet J, Ficat P, Lartigue G, Tran MA. Clinical research on intraosseous pressure in the upper femoral metaphysis and epiphysis in humans. Application to the diagnosis of ischemia and necrosis. Rev Rhum Mal Osteoartic. 1972;39:717-723.

140. Camp JF, Colwell CW. Core decompression of the femoral head for osteonecrosis. J Bone Joint Surg (Am). 1986;68(9):1313-1319.

141. Hauzeur JP, Pasteels JL, Orloff S. Bilateral non-traumatic aseptic osteonecrosis in the femoral head. An experimental study of incidence. J Bone Joint Surg (Am). 1987;69(8):1221-1225.

142. Lausten GS, Arnoldi CC. Blood perfusion uneven in femoral head osteonecrosis. Acta Orthop Scand. 1993;64(5):533-536. doi: 10.3109/17453679308993686

143. Kirer Th, Pedersen NW, Kristensen KD, Starklint H. Intraosseous pressure and oxygen tension in avascular necrosis and osteoarthritis of the hip. J Bone Joint Surg (Br). 1990;72:1023-1030. doi: 10.1302/0301-620X.72B6.2246284

144. Ficat RF. Treatment of avascular necrosis of the femoral head. In The Hip: Proceedings of the Eleventh Open Meeting of the Hip Society. 1983:279-295.

145. Winet H, Hsieh A, Bao JY. Approaches to study of ischemia in bone. J Biomed Mater Res. 1998;43(4):410-421. doi: 10.1002/(sici)1097-4636(199824)43:4<410::aid-jbm8>3.0.co;2-b

146. Kaneko K, Chen H, Kaufman M, Sverdlov I, Stein EM, Park-Min KH. Glucocorticoid-induced osteonecrosis in systemic lupus erythematosus patients. Clin Transl Med. 2021;11(10):e526. doi: 10.1002/ctm2.526

147. Kerachian MA, Séguinb C, Harvey EJ. Glucocorticoids in osteonecrosis of the femoral head: A new understanding of the mechanisms of action. J Steroid Biochem Mol Biol. 2009;114:121-128. doi: 10.1016/j.jsbmb.2009.02.007

148. Weinstein RS. Glucocorticoid-induced osteoporosis and osteonecrosis. Endocrinol Metab Clin North Am. 2012;41(3):595-611. doi: 10.1016/j.ecl.2012.04.004

149. Calder JD, Buttery L, Revell PA, Pearse M, Polak JM. Apoptosis – A significant cause of bone cell death in osteonecrosis of the femoral head. J Bone Joint Surg Br. 2004;86:1209-1213. doi: 10.1302/0301-620x.86b8.14834

150. Weinstein RS, Nicholas RW, Manolagas SC. Apoptosis of osteocytes in glucocorticoid-induced osteonecrosis of the hip. J Clin Endocrin Metab. 2000;85(8):2907-2912. doi: 10.1210/jcem.85.8.6714

151. Almeida M, Han L, Ambrogini E, Weinstein RS, Manolagas SC. Glucocorticoids and tumor necrosis factor α increase oxidative stress and suppress Wnt protein signaling in osteoblasts. J Biol Chem. 2011;286(52):44326-44335. doi: 10.1074/jbc.m111.283481

152. Moutsatsou P, Kassi E, Papavassiliou AG. Glucocorticoid receptor signaling in bone cells. Trends Mol Med. 2012;18(6):348-359. doi: 10.1016/j.molmed.2012.04.005

153. Mirzai R, Chang C, Greenspan A, Gershwin ME. The pathogenesis of osteonecrosis and the relationships to corticosteroids. J Asthma. 1999;36(1):77-95. doi: 10.3109/02770909909065152

154. Arlet J. Nontraumatic avascular necrosis of the femoral head: Past, present and future. Clin Orthop Rel Res. 1992;277:12-21.

155. Frost HM. The etiodynamics of aseptic necrosis of the femoral head. National Institutes of Health;1965.

156. Solomon L. Aseptic necrosis of the femoral head in iron overload. Osteoporosis Res. 1974;4:457-461.

157. Zalavras C, Shah S, Birnbaum MJ, Frenkel B. Role of apoptosis in glucocorticoid-induced osteoporosis and osteonecrosis. Crit Rev Eukaryot Gene Expr. 2003;13(2-4):221-235. doi: 10.1615/CritRevEukaryotGeneExpr.v13.i24.140

158. Zhang QL, Lv J, Jin L. Role of coagulopathy in glucocorticoid-induced osteonecrosis of the femoral head. J Int Med Res. 2017;46(6):2141-2148. doi: 10.1177/0300060517700299

159. Zuo W, Guo W, Yu H, Liu P, Zhang QD. Role of junction-mediating and regulatory protein in the pathogenesis of glucocorticoid-induced endothelial cell lesions. Orthop Surg. 2020;9999(9999):1-10. doi: 10.1111/os.12680

160. Chikatsu N, Takeuchi Y, Kikuchi T, Fujita N, Tsuruo T, et al. Bone derived vascular endothelial cells: Putative osteoblast progenitors suppress osteoclast-like cell formation in bone marrow cultures. Bone. 1998;23(Suppl):S331.

161. Collin-Osdoby P. Role of vascular endothelial cells in bone biology. J CeUul Biochem. 1994;55:304-309. doi: 10.1002/jcb.240550306

162. Khoury E, del Puerto G, McAdams J, Nyiredy K, Mathews C, Pun KK, et al. Anatomical and functional associations between endothelial cells and osteoblasts. J Bone Miner Res. 1993;8(Suppl):S159.

163. Tsukahara H, Hori C, Hiraoka M, Yamamoto K, Ishii Y, Mayumi M. Endothelin subtype A receptor antagonist induces osteopenia in growing rats. Metabolism. 1998;47(11):1403-1407. doi: 10.1016/s0026-0495(98)90313-4

164. Zaidi M, Alam AS, Bax BE, Shankar VS, Bax CM, Gill JS, et al. Role of the endothelial cell in osteoclast control: New perspectives. Bone. 1993;14(2):97-102. doi: 10.1016/8756-3282(93)90234-2

165. Zecchi-Orlandini S, Formigli L, Brandi ML. Relationship between endothelium and bone cells. Ital J Miner Electrolyte Metab. 1993;7:147-153.

166. Vallance P, Collier J, Moncada S. Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man. Lancet. 1989;2:997-1000. doi: 10.1016/s0140-6736(89)91013-1

167. Tagawa T, Imaizumi T, Endo T, Shiramoto M, Harasawa Y, Takeshita A. Role of nitric oxide in reactive hyperemia in human forearm vessels. Circulation. 1994;90(5):2285-2290. doi: 10.1161/01.cir.90.5.2285

168. Iuchi T. Glucocorticoid excess induces superoxide production in vascular endothelial cells and elicits vascular endothelial dysfunction. Circ Res. 2002;92(1):81-87. doi: 10.1161/01.res.0000050588.35034.3c

169. Wever RMF, Lüscher TF, Cosentino F, Rabelink TJ. Atherosclerosis and the two faces of endothelial nitric oxide synthase. Circulation. 1998;97:108-112. doi: 10.1161/01.cir.97.1.108

170. Harrison DG. Endothelial function and oxidant stress. Clin Cardiol. 1997;20(II):II11-II17. doi: 10.1002/j.1932-8737.1997.tb00007.x

171. Lüscher TF, Barton M. Biology of the endothelium. Clin Cardiol. 1997;20(II):II3-II10. doi: 10.1002/j.1932-8737.1997.tb00006.x

172. Panza J, Casino PR, Kilcoyne CM, Quyyumi AA. Role of endotheliumderived nitric oxide in the abnormal endotheliumdependent vascular relaxation of patients with essential hypertension. Circulation. 1993;87:1468-1474. doi: 10.1161/01.cir.87.5.1468

173. Yu QS, Guo WS, Cheng LM, Lu YF, Shen JY, Li P. Glucocorticoids significantly influence the transcriptome of bone microvascular endothelial cells of human femoral head. Chin Med J (Engl). 2015;128(14):1956-1963. doi: 10.4103/0366-6999.160564

174. Chen C, Yang S, Feng Y, Wu X, Chen D, Yu Q, et al. Impairment of two types of circulating endothelial progenitor cells in patients with glucocorticoid-induced avascular osteonecrosis of the femoral head. Joint Bone Spine. 2013;80(1):70-76. doi: 10.1016/j.jbspin.2012.02.015

175. Yue J, Wan F, Zhang Q, Wen P, Cheng L, Li P, et al. Effect of glucocorticoids on miRNA expression spectrum of rat femoral head microcirculation endothelial cells. Gene. 2018;651:126-133. doi: 10.1016/j.gene.2018.01.057

176. Zha X, Sun B, Zhang R, Li C, Yan Z, Chen J. Regulatory effect of microRNA-34a on osteogenesis and angiogenesis in glucocorticoid-induced osteonecrosis of the femoral head. J Orthop Res. 2018;36(1):417-424. doi: 10.1002/jor.23613

177. Zhang YL, Yin JH, Ding H, Zhang W, Zhang CQ, Gao YS. Vitamin K2 prevents glucocorticoid-induced osteonecrosis of the femoral head in rats. Int J Biol Sci. 2016;12(4):347-358. doi: 10.7150/ijbs.13269

178. Beaulieu E, Morand EF. Role of GILZ in immune regulation, glucocorticoid actions and rheumatoid arthritis. Nat Rev Rheumatol. 2011;7:340-348. doi: 10.1038/nrrheum.2011.59

179. Folkman J, Ingber DE. Angiostatic steroids. Method of discovery and mechanism of action. Ann Surg. 1987;206:374-383. doi: 10.1097/00000658-198709000-00016

180. Boss JH, Misselevich I. Osteonecrosis of the femoral head of laboratory animals: The lessons learned from a comparative study of osteonecrosis in man and experimental animals. Vet Pathol. 2003;40:345-354. doi: 10.1354/vp.40-4-345

181. van Giezen JJ, Jansen JW. Inhibition of fibrinolytic activity in-vivo by dexamethasone is counterbalanced by an inhibition of platelet aggregation. Thromb Haemost. 1992;68:69-73. doi: 10.1055/s-0038-1656320

182. Yang C, Yang S, Du J, Li J, Xu W, Xiong Y. Experimental study of vascular endothelial growth factor gene therapy for avascular necrosis of the femoral head. J Huazhong Univ Sci Technolog Med Sci. 2003;23(3):297-299. doi: 10.1007/BF02829520

183. Li X, Jin L, Cui Q, Wang GJ, Balian G. Steroid effects on osteogenesis through mesenchymal cell gene expression. Osteoporos Int. 2005;16:101-108. doi: 10.1007/s00198-004-1649-7

184. Harada I. The effects of glucocorticoids on angiogenesis in vitro. Nippon Seikeigeka Gakkai Zasshi. 1992;66:763-770.

185. Wolff JE, Guerin C, Laterra J, Bressler J, Indurti RR, Brem H, et al. Dexamethasone reduces vascular density and plasminogen activator activity in 9L rat brain tumors. Brain Res. 1993;604(1-2):79-85. doi: 10.1016/0006-8993(93)90354-p

186. Boss JH. Experimental models of osteonecrosis of the femoral head. J Orthop Sci. 2004;9:533-534. doi: 10.1007/s00776-004-0817-0

187. Wang GJ, Sweet DE, Reger SI, Thompson RC. Fat-cell changes as a mechanism of avascular necrosis of the femoral head in cortisone-treated rabbits. J Bone Joint Surg Am. 1977;59:729-735.

188. Chen XC, Weng J, Chen XQ, Du JZ, Zhu MP, Pan YQ, Liu M. Relationships among magnetic resonance imaging, histological findings, and IGF-I in steroid-induced osteonecrosis of the femoral head in rabbits. J Zhejiang Univ Sci B. 2008;9(9):739-746. doi: 10.1631/jzus.B0820127

189. Ostrum RF; Chao EYS; Bassett CAL, Brighton CT, Einhorn TA, Lucas TS, et al. Bone injury, regeneration and repair. In: Simon SR (ed). Orthopaedic Basic Science. Rosemont:American Academy of Orthopaedic Surgeons;1994:277-323.

190. Kawai K, Tamaki A, Hirohata K. Steroid-induced accumulation of lipid in the osteocytes of the rabbit femoral head. A histochemical and electron microscopic study. J Bone Joint Surg Am. 1985;67(5):755-763.

191. Boskey AL, Raggio CL, Bullough PG, Kinnett JG. Changes in the bone tissue lipids in persons with steroid- and alcoholinduced osteonecrosis. Clin Orthop Relat Res. 1983;172:289-295. doi: 10.1097/00003086-198301000-00046

192. Wang GJ, Cui Q, Balian G. The Nicolas Andry award. The pathogenesis and prevention of steroid-induced osteonecrosis. Clin Orthop Relat Res. 2000;370:295-310. doi: 10.1097/00003086-200001000-00030

193. Miyanishi K, Yamamoto T, Irisa T, Yamashita A, Jingushi S, Noguchi Y, et al. Bone marrow fat cell enlargement and a rise in intraosseous pressure in steroid-treated rabbits with osteonecrosis. Bone. 2002;30(1):185-190. doi: 10.1016/s8756-3282(01)00663-9

194. Jaffe WL, Epstein M, Heyman N, Mankin HJ. The effect of cortisone on femoral and humeral heads in rabbits. An experimental study. Clin Orthop Relat Res. 1972;82:221-228.

195. Hernigou P, Lambotte JC. Decrease in the mesenchymal stemcell pool in the proximal femur in corticosteroid-induced osteonecrosis. J Bone Joint Surg Br. 1999;81:349-355. doi: 10.1302/0301-620x.81b2.8818

196. Jones JP. Fat embolism and osteonecrosis. Orthop Clin North Am. 1985;16:595-633. doi: 10.1016/S0030-5898(20)30431-4

197. Cui Q, Wang GJ, Balian G. Steroid-induced adipogenesis in a pluripotential cell line from bone marrow. J Bone Joint Surg Am. 1997;79(7):1054-1063. doi: 10.2106/00004623-199707000-00012

198. Motomura G, Yamamoto T, Irisa T, Miyanishi K, Nishida K, Iwamoto Y. Dose effects of corticosteroids on the development of osteonecrosis in rabbits. J Rheumatol. 2008;35(12):2395-2399. doi: 10.3899/jrheum.080324

199. Motomura G, Yamamoto T, Miyanishi K, Kondo K, Hirota Y, Iwamoto Y. Risk factors for developing osteonecrosis after prophylaxis in steroid-treated rabbits. J Rheumatol. 2008;35(12):2391-2394. doi: 10.3899/jrheum.080416

200. Jones JP, Ramirez S, Doty SB. The pathophysiologic role of fat in dysbaric osteonecrosis. Clin Orthop Relat Res. 1993;296:256-264. doi: 10.1097/00003086-199311000-00042

201. Wang T, Wang F, Liu T, Sun M, An F, Liu C, et al. OPG/RANKL/RANK gene methylation among alcohol-induced femoral head necrosis in northern Chinese men. J Orthop Surg Res. 2021;16(1):223. doi: 10.1186/s13018-021-02356-y

202. Suh KT, Kim SW, Roh HL, Youn MS, Jung JS. Decreased osteo genic differentiation of mesenchymal stem cells in alcoholinduced osteonecrosis. Clin Orthop Relat Res. 2005;431:220-225. doi: 10.1097/01.blo.0000150568.16133.3

203. Cui Q, Wang Y, Saleh KJ, Wang GJ, Balian G. Alcohol-induced adipogenesis in a cloned bone-marrow stem cell. J Bone Joint Surg Am. 2006;88(3):148-154. doi: 10.2106/JBJS.F.00534

204. Wang Y, Li Y, Mao K, Li J, Cui Q, Wang GJ. Alcohol-induced adipogenesis in bone and marrow: A possible mechanism for osteonecrosis. Clin Orthop Relat Res. 2003;410:213-224. doi: 10.1097/01.blo.0000063602.67412.83

205. Kenzora JE. Ischemic necrosis of femoral head. Part I. Accumulative cell stress: A hypothesis for the etiology of idiopathic osteonecrosis. Instr Course Lect. 1983;32:242-252.

206. Saito S, Inoue A, Ono K. Intramedullary haemorrhage as a possible cause of avascular necrosis of the femoral head. The histology of 16 femoral heads at the silent stage. J Bone Joint Surg Br Vol. 1987;69-B(3):346-351. doi: 10.1302/0301-620x.69b3.3584182

207. Glimcher MJ, Kenzora JE. The biology of osteonecrosis of the human femoral head and its clinical implication: I. Tissue biology. Clin Orthop Relat Res. 1979;138:284-309.

208. Glimcher MJ, Kenzora JE. The biology of osteonecrosis of the human femoral head and its clinical implications: II. The pathological changes in the femoral head as an organ and in the hip joint. Clin Orthop Relat Res. 1979;139:283-312.

209. Wang C, Meng H, Wang Y, Zhao B, Zhao C, Sun W, et al. Analysis of early stage osteonecrosis of the human femoral head and the mechanism of femoral head collapse. Int J Biol Sci. 2018;14(2):156-164. doi: 10.7150/ijbs.18334

210. Cao HJ, Zheng LZ, Wang N, Wang LY, Li Y, Li D, et al. Src blockage by siRNA inhibits VEGF-induced vascular hyperpemeability and osteoclast activity – An in vitro mechanism study for preventing destructive repair of osteonecrosis. Bone. 2015;74:58-68. doi: 10.1016/j.bone.2014.12.060

211. Ficat RP. Idiopathic bone necrosis of the femoral head. Early diagnosis and treatment. J Bone Joint Surg Br. 1985;67:3-9.

212. Liu GB, Li R, Lu Q, Ma HY, Zhang YX, Quan Q, et al. Three-dimensional distribution of cystic lesions in osteonecrosis of the femoral head. J Orthop Translat. 2019;22:109-115. doi: 10.1016/j.jot.2019.10.010

213. Gao F, Han J, He Z, Li Z. Radiological analysis of cystic lesion in osteonecrosis of the femoral head. Int Orthop. 2018;42:1615-1621. doi: 10.1007/s00264-018-3958-z

214. Kawano K, Motomura G, Ikemura S, Yamaguchi R, Baba S, Xu M, et al. Differences in the microarchitectural features of the lateral collapsed lesion between osteonecrosis and subchondral insufficiency fracture of the femoral head. Bone. 2020;141:115585. doi: 10.1016/j.bone.2020.115585

215. Chen Y, Miao Y, Liu K, Xue F, Zhu B, Zhang C, et al. Evolutionary course of the femoral head osteonecrosis: Histopathological-radiologic characteristics and clinical staging systems. J Orthop Translat. 2021;32:28-40. doi: 10.1016/j.jot.2021.07.004

216. Wang P, Wang C, Meng H, Liu G, Li H, Gao J, et al. The role of structural deterioration and biomechanical changes of the necrotic lesion in collapse mechanism of osteonecrosis of the femoral head. Orthop Surg. 2022;14(5):831-839. doi: 10.1111/os.13277

217. Li W, Sakai T, Nishii T, Nakamura N, Takao M, Yoshikawa H, et al. Distribution of TRAP-positive cells and expression of HIF-1alpha, VEGF, and FGF-2 in the reparative reaction in patients with osteonecrosis of the femoral head. J Orthop Res. 2009;27(5):694-700. doi: 10.1002/jor.20802

218. Hamada H, Takao M, Sakai T, Sugano N. Subchondral fracture begins from the bone resorption area in osteonecrosis of the femoral head: A micro-computerised tomography study. Int Orthop. 2018;42:1479-1484. doi: 10.1007/s00264-018-3879-x

219. Motomura G, Yamamoto T, Yamaguchi R, Ikemura S, Nakashima Y, Mawatari T, et al. Morphological analysis of collapsed regions in osteonecrosis of the femoral head. J Bone Joint Surg Br. 2011;93(2):184-187. doi: 10.1302/0301-620X.93B225476

220. Castaneda S, Roman-Blas JA, Largo R, Herrero-Beaumont G. Subchondral bone as a key target for osteoarthritis treatment. Biochem Pharmacol. 2012;83(3):315-323. doi: 10.1016/j.bcp.2011.09.018

221. Utsunomiya T, Motomura G, Ikemura S, Kubo Y, Sonoda K, Hatanaka H, et al. Effects of sclerotic changes on stress concentration in early-stage osteonecrosis: A patient-specific, 3D finite element analysis. J Orthop Res. 2018;36(12):3169-3177. doi: 10.1002/jor.24124

222. Karasuyama K, Yamamoto T, Motomura G, Sonoda K, Kubo Y, Iwamoto Y. The role of sclerotic changes in the starting mechanisms of collapse: A histomorphometric and FEM study on the femoral head of osteonecrosis. Bone. 2015;81:644-648. doi: 10.1016/j.bone.2015.09.009

223. Yang JW, Koo KH, Lee MC, Yang P, Noh MD, Kim SY, et al. Mechanics of femoral head osteonecrosis using three-dimensional finite element method. Arch Orthop Trauma Surg. 2002;122(2):88-92. doi: 10.1007/s004020100324

224. Moreira CA, Bilezikian JP. Stress fractures: concepts and therapeutics. J Clin Endocrinol Metab. 2017;102:525-534. doi: 10.1210/jc.2016-2720

225. Ansari S, Goyal T, Kalia RB, Paul S, Singh S. Prediction of collapse in femoral head osteonecrosis: Role of volumetric assessment. Hip Int. 2020;32(5):596-603. doi: 10.1177/1120700020978587

226. Zhao WPLF, Lu QP, Wu ZH, Shi ZC. 3D reconstruction and FEA in the prediction of osteonecrosis collapse of the femoral head. Chin J Biomed Eng. 2005;24:784-787.

227. Yu T, Xie L, Zhang Z, Ke X, Liu Y. Prediction of osteonecrosis collapse of the femoral head based on the proportion of the proximal sclerotic rim. Int Orthop. 2015;39:1045-1050. doi: 10.1007/s00264-014-2602-9

228. Yu T, Xie L, Chu F. A sclerotic rim provides mechanical support for the femoral head in osteonecrosis. Orthopedics. 2015;38:e374-e379. doi: 10.3928/01477447-20150504-53

229. Chen Z, Xu Y, Qi Z, Zho J. The formation and function of the sclerosis rim in the femoral head: A biomechanical point of view. Med Eng Phys. 2015;37:1125-1132. doi: 10.1016/j.medengphy.2015.09.005

230. Bullough PG, DiCarlo EF. Subchondral avascular necrosis: a common cause of arthritis. Ann Rheum Dis. 1990;49(6):412-420. doi: 10.1136/ard.49.6.412

231. Volokh KY, Yoshida H, Leali A, Fetto JF, Chao EY. Prediction of femoral head collapse in osteonecrosis. J Biomech Eng. 2006;128:467-470. doi: 10.1115/1.2187050

232. Daniel M, Herman S, Dolinar D, Iglic A, Sochor M, Kralj-Iglic V. Contact stress in hips with osteonecrosis of the femoral head. Clin Orthop Relat Res. 2006;447:92-99. doi: 10.1097/01.blo.0000203472.88926.c8

233. Kato S, Yamada H, Terada N, Masuda K, Lenz ME, Morita M, et al. Joint biomarkers in idiopathic femoral head osteonecrosis: comparison with hip osteoarthritis. J Rheumatol. 2005;32(8):1518-1523.


Рецензия

Для цитирования:


Бялик В.Е., Макаров М.А., Бялик Е.И., Макаров С.А., Каратеев А.Е., Нестеренко В.А., Черникова А.А., Капитонов Д.В., Горелова А.И. Аваскулярный некроз костной ткани: определение, эпидемиология, виды, факторы риска, патогенез заболевания. Аналитический обзор литературы. Научно-практическая ревматология. 2023;61(2):220-235. https://doi.org/10.47360/1995-4484-2023-220-235

For citation:


Bialik V.E., Makarov M.A., Byalik E.I., Makarov S.A., Karateev A.E., Nesterenko V.A., Chernikova A.A., Kapitonov D.V., Gorelova A.I. Avascular necrosis of bone tissue: Definition, epidemiology, types, risk factors, pathogenesis of the disease. Analytical review of the literature. Rheumatology Science and Practice. 2023;61(2):220-235. (In Russ.) https://doi.org/10.47360/1995-4484-2023-220-235

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ISSN 1995-4484 (Print)
ISSN 1995-4492 (Online)