Современная концепция аутоиммунитета в ревматологии
https://doi.org/10.47360/1995-4484-2023-397-420
Аннотация
В спектре механизмов хронического воспаления центральное место занимают два фундаментальных патологических процесса – аутоиммунитет и аутовоспаление. Аутоиммунитет и аутовоспаление – взаимопотенциирующие патологические процессы, их развитие рассматривают в рамках «иммуновоспалительного» континуума (непрерывность при многообразии элементов), отражающего тесную взаимосвязь между врожденным и приобретенным типами иммунного ответа. Аутоиммунитет – ведущий механизм патогенеза большой группы хронических воспалительных заболеваний человека, определяющихся как аутоиммунные болезни, частота которых в популяции превышает 10%. Достижения молекулярной биологии, фармакогенетики и биоинформатики создали предпосылки для индивидуализации терапии аутоиммунных ревматических заболеваний в рамках концепции «персонифицированной» (personalized) медицины. Изучение механизмов иммунопатогенеза, совершенствование диагностики, расшифровка природы молекулярной таксономии, разработки подходов к профилактике и персонифицированной терапии аутоиммунных заболеваний человека относятся к числу приоритетных направлений медицины XXI века
Об авторе
Е. Л. Насонов
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»; ФГАОУ ВО «Первый Московский государственный медицинский университет имени И.М. Сеченова» Минздрава России (Сеченовский Университет)
Россия
Россия
115522, Москва, Каширское шоссе, 34а
119991, Москва, ул. Трубецкая, 8, стр. 2
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Рецензия
Для цитирования:
Насонов Е.Л. Современная концепция аутоиммунитета в ревматологии. Научно-практическая ревматология. 2023;61(4):397-420. https://doi.org/10.47360/1995-4484-2023-397-420
For citation:
Nasonov E.L. Modern concept of autoimmunity in rheumatology. Rheumatology Science and Practice. 2023;61(4):397-420. (In Russ.) https://doi.org/10.47360/1995-4484-2023-397-420
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