Capabilities of magnetic resonance imaging in the diagnosis of idiopathic inflammatory myopathies
https://doi.org/10.47360/1995-4484-2023-689-699
Abstract
Idiopathic inflammatory myopathies (IIM) are a group of chronic autoimmune conditions characterized by proximal muscle weakness and potentially accompanied by a range of extramuscular clinical manifestations. There are subtypes of IIM including dermatomyositis (DM), polymyositis (PM), immune-mediated necrotizing myopathy (IMNM), sporadic inclusion body myositis (sIBM), overlap myositis (OM) with subgroup of anti-synthetase syndrome (ASS) and cancer-associated myositis. Taking into account rarity of the disease, heterogeneity of clinical presentation, difficulties in detection methods and interpretation of myositis associated autoantibodies (MAAs) and myositis specific autoantibodies (MSAs), search for objective imaging methods of muscle damage continues. This is important to definitive diagnosis, predicting subtypes of IIM and case follow-up. One of the most promising methods is magnetic resonance imaging (MRI). The aim of the review was to examine the role of MRI in assessment muscle damage, in particular, most typical MRI-findings and there features in different types of IIM with further clinical cases.
About the Author
A. A. Kolomeychuk
V.A. Nasonova Research Institute of Rheumatology
Russian Federation
Competing Interests:
Russian Federation
Alena A. Kolomeychuk.
115522, Moscow, Kashirskoye Highway, 34A
Competing Interests:
None
References
1. Ashton C, Paramalingam S, Stevenson B, Brusch A, Needham M. Idiopathic inflammatory myopathies: A review. Intern Med J. 2021;51(6):845-852. doi: 10.1111/imj.15358
2. Lundberg IE, Fujimoto M, Vencovsky J, Aggarwal R, Holmqvist M, Christopher-Stine L, et al. Idiopathic inflammatory myopathies. Nat Rev Dis Primers. 2021;7(1):86. doi: 10.1038/s41572-021-00321-x
3. Cardelli C, Zanframundo G, Cometi L, Marcucci E, Biglia A, Cavagna L, et al. Idiopathic inflammatory myopathies: One year in review 2021. Clin Exp Rheumatol. 2022;40(2):199-209. doi: 10.55563/clinexprheumatol/vskjxi
4. Liu Y, Zheng Y, Hao H, Yuan Y. Narrative review of autoantibodies in idiopathic inflammatory myopathies. Ann Transl Med. 2023;11(7):291. doi: 10.21037/atm-21-475
5. Corona-Sanchez EG, Martínez-García EA, Lujano-Benítez AV, Pizano-Martinez O, Guerra-Durán IA, Chavarria-Avila E, et al. Autoantibodies in the pathogenesis of idiopathic inflammatory myopathies: Does the endoplasmic reticulum stress response have a role? Front Immunol. 2022;13:940122. doi: 10.3389/fimmu.2022.940122
6. Tanboon J, Uruha A, Stenzel W, Nishino I. Where are we moving in the classification of idiopathic inflammatory myopathies? Curr Opin Neurol. 2020;33(5):590-603. doi: 10.1097/WCO.0000000000000855
7. Mariampillai K, Granger B, Amelin D, Guiguet M, Hachulla E, Maurier F, et al. Development of a new classification system for idiopathic inflammatory myopathies based on clinical manifestations and myositis-specific autoantibodies. JAMA Neurol. 2018;75(12):1528-1537. doi: 10.1001/jamaneurol.2018.2598
8. Bohan A, Peter JB. Polymyositis and dermatomyositis (first of two parts). N Engl J Med. 1975;292(7):344-347. doi: 10.1056/NEJM197502132920706
9. Bohan A, Peter JB. Polymyositis and dermatomyositis (second of two parts). N Engl J Med. 1975;292(8):403-407. doi: 10.1056/NEJM197502202920807
10. Lundberg IE, Tjärnlund A, Bottai M, Werth VP, Pilkington C, Visser M, et al.; International Myositis Classification Criteria Project consortium, The Euromyositis register and The Juvenile Dermatomyositis Cohort Biomarker Study and Repository (JDRG) (UK and Ireland). 2017 European League Against Rheumatism/ American College of Rheumatology classification criteria for adult and juvenile idiopathic inflammatory myopathies and their major subgroups. Ann Rheum Dis. 2017;76(12):1955-1964. doi: 10.1136/annrheumdis-2017-211468
11. Pinto B, Janardana R, Nadig R, Mahadevan A, Bhatt AS, Raj JM, et al. Comparison of the 2017 EULAR/ACR criteria with Bohan and Peter criteria for the classification of idiopathic inflammatory myopathies. Clin Rheumatol. 2019;38(7):1931-1934. doi: 10.1007/s10067-019-04512-6
12. Leclair V, Notarnicola A, Vencovsky J, Lundberg IE. Polymyositis: Does it really exist as a distinct clinical subset? Curr Opin Rheumatol. 2021;33(6):537-543. doi: 10.1097/BOR.0000000000000837
13. Lundberg IE, Tjärnlund A, Bottai M, Werth VP, Pilkington C, de Visser M, et al.; International Myositis Classification Criteria Project Consortium, the Euromyositis Register, and the Juvenile Dermatomyositis Cohort Biomarker Study and Repository (UK and Ireland). 2017 European League Against Rheumatism/American College of Rheumatology classification criteria for adult and juvenile idiopathic inflammatory myopathies and their major subgroups. Arthritis Rheumatol. 2017;69(12):2271-2282. doi: 10.1002/art.40320
14. Casal-Dominguez M, Pinal-Fernandez I, Pak K, Huang W, Selva-O’Callaghan A, Albayda J, et al. Performance of the 2017 European Alliance of Associations for Rheumatology/American College of Rheumatology classification criteria for idiopathic inflammatory myopathies in patients with myositis-specific autoantibodies. Arthritis Rheumatol. 2022;74(3):508-517. doi: 10.1002/art.41964
15. Kuo GP, Carrino JA. Skeletal muscle imaging and inflammatory myopathies. Curr Opin Rheumatol. 2007;19(6):530-535. doi: 10.1097/BOR.0b013e3282efdc66
16. Paramalingam S, Counsel P, Mastaglia FL, Keen H, Needham M. Imaging in the diagnosis of idiopathic inflammatory myopathies; indications and utility. Expert Rev Neurother. 2019;19(2):173-184. doi: 10.1080/14737175.2019.1572507
17. Litvinenko IV, Zhivolupov SA, Bardakov SN, Samartsev IN, Rashidov NA, Yakovlev EV. Inflammatory myopathies: Pathogenesis, clinical presentation, diagnosis, treatment. Bulletin of the Russian Military Medical Academy. 2015;3(51):217-226 (In Russ.).
18. Goodwin DW. Imaging of skeletal muscle. Rheum Dis Clin North Am. 2011;37(2):245-vii. doi: 10.1016/j.rdc.2011.01.007
19. Kumar Y, Wadhwa V, Phillips L, Pezeshk P, Chhabra A. MR imaging of skeletal muscle signal alterations: Systematic approach to evaluation. Eur J Radiol. 2016;85(5):922-935. doi: 10.1016/j.ejrad.2016.02.007
20. Pipitone N. Value of MRI in diagnostics and evaluation of myositis. Curr Opin Rheumatol. 2016;28(6):625-630. doi: 10.1097/BOR.0000000000000326
21. Venturelli N, Tordjman M, Ammar A, Chetrit A, Renault V, Carlier RY. Contribution of muscle MRI for diagnosis of myopathy. Rev Neurol (Paris). 2023;179(1-2):61-80. doi: 10.1016/j.neurol.2022.12.002
22. Caetano AP, Alves P. Advanced MRI patterns of muscle disease in inherited and acquired myopathies: What the radiologist should know. Semin Musculoskelet Radiol. 2019;23(3):e82-e106. doi: 10.1055/s-0039-1684022
23. Mercuri E, Pichiecchio A, Allsop J, Messina S, Pane M, Muntoni F. Muscle MRI in inherited neuromuscular disorders: Past, present, and future. J Magn Reson Imaging. 2007;25(2):433-440. doi: 10.1002/jmri.20804
24. Willis TA, Hollingsworth KG, Coombs A, Sveen ML, Andersen S, Stojkovic T, et al. Quantitative muscle MRI as an assessment tool for monitoring disease progression in LGMD2I: A multicentre longitudinal study. PLoS One. 2013;8(8):e70993. doi: 10.1371/journal.pone.0070993
25. Vlodavets DO, Kazakov DO. Diagnostic capabilities of MRI of muscles in neuromuscular diseases. Russian Neurological Journal. 2014;(3):4-13 (In Russ.).
26. Spalkit S, Sinha A, Prakash M, Sandhu MS. Dermatomyositis: Patterns of MRI findings in muscles, fascia and skin of pelvis and thigh. Eur J Radiol. 2021;141:109812. doi: 10.1016/j.ejrad.2021.109812
27. Malartre S, Bachasson D, Mercy G, Sarkis E, Anquetil C, Benveniste O, et al. MRI and muscle imaging for idiopathic inflammatory myopathies. Brain Pathol. 2021;31(3):e12954. doi: 10.1111/bpa.12954
28. Merve A, Schneider U, Kara E, Papadopoulou C, Stenzel W. Muscle biopsy in myositis: What the rheumatologist needs to know. Best Pract Res Clin Rheumatol. 2022;36(2):101763. doi: 10.1016/j.berh.2022.101763
29. Maurer B, Walker UA. Role of MRI in diagnosis and management of idiopathic inflammatory myopathies. Curr Rheumatol Rep. 2015;17(11):67. doi: 10.1007/s11926-015-0544-x
30. Paramalingam S, Needham M, Harris S, O’Hanlon S, Mastaglia F, Keen H. Muscle B mode ultrasound and shear-wave elastography in idiopathic inflammatory myopathies (SWIM): Criterion validation against MRI and muscle biopsy findings in an incident patient cohort. BMC Rheumatol. 2022;6(1):47. doi: 10.1186/s41927-022-00276-w
31. Khelkovskaya-Sergeeva AN, Ananyeva LP, Kazakov DO, Nasonov EL. Use of magnetic resonance imaging in the diagnosis of idiopathic inflammatory myopathies. Modern Rheumatology Journal. 2019;13(1):95-100 (In Russ.). doi: 10.14412/1996-7012-2019-1-95-100
32. Meyer HJ, Schneider I, Emmer A, Kornhuber M, Surov A. Associations between magnetic resonance imaging and EMG findings in myopathies. Acta Neurol Scand. 2020;142(5):428-433. doi: 10.1111/ane.13284
33. Barsotti S, Aringhieri G, Mugellini B, Torri F, Minichilli F, Tripoli A, et al. The role of magnetic resonance imaging in the diagnostic work-out of myopathies: Differential diagnosis between inflammatory myopathies and muscular dystrophies. Clin Exp Rheumatol. 2023;41(2):301-308. doi: 10.55563/clinexprheumatol/dkmz6o.
34. Guimarães JB, Nico MA, Omond AG, Aivazoglou LU, Jorge RB, Zanoteli E, et al. Diagnostic imaging of inflammatory myopathies: New concepts and a radiological approach. Curr Rheumatol Rep. 2019;21(3):8. doi: 10.1007/s11926-019-0807-z
35. Pilania K, Jankharia B. Role of MRI in idiopathic inflammatory myopathies: A review article. Acta Radiol. 2022;63(2):200-213. doi: 10.1177/0284185121990305
36. Filli L, Winklhofer S, Andreisek G, Del Grande F. Imaging of myopathies. Radiol Clin North Am. 2017;55(5):1055-1070. doi: 10.1016/j.rcl.2017.04.010
37. Dalakas MC. Pathophysiology of inflammatory and autoimmune myopathies. Presse Med. 2011;40(4 Pt 2):e237-e247. doi: 10.1016/j.lpm.2011.01.005
38. Kamperman RG, van der Kooi AJ, de Visser M, Aronica E, Raaphorst J. Pathophysiological mechanisms and treatment of dermatomyositis and immune mediated necrotizing myopathies: A focused review. Int J Mol Sci. 2022;23(8):4301. doi: 10.3390/ijms23084301
39. Naddaf E, Barohn RJ, Dimachkie MM. Inclusion body myositis: Update on pathogenesis and treatment. Neurotherapeutics. 2018;15(4):995-1005. doi: 10.1007/s13311-018-0658-8
40. Greenberg SA. Inclusion body myositis: clinical features and pathogenesis. Nat Rev Rheumatol. 2019;15(5):257-272. doi: 10.1038/s41584-019-0186-x
41. Mucke J, Cornet A, Witte T, Schneider M. Association of common variable immunodeficiency and rare and complex connective tissue and musculoskeletal diseases. A systematic literature review. Clin Exp Rheumatol. 2022;134(5 Suppl 40):40-45. doi: 10.55563/clinexprheumatol/bbuvih
42. Damian L, Login CC, Solomon C, Belizna C, Encica S, Urian L, et al. Inclusion body myositis and neoplasia: A narrative review. Int J Mol Sci. 2022;23(13):7358. doi: 10.3390/ijms23137358
43. Guimaraes JB, Zanoteli E, Link TM, de Camargo LV, Facchetti L, Nardo L, et al. Sporadic inclusion body myositis: MRI findings and correlation with clinical and functional parameters. AJR Am J Roentgenol. 2017;209(6):1340-1347. doi: 10.2214/AJR.17.17849
44. Dahlbom K, Geijer M, Oldfors A, Lindberg C. Association between muscle strength, histopathology, and magnetic resonance imaging in sporadic inclusion body myositis. Acta Neurol Scand. 2019;139(2):177-182. doi: 10.1111/ane.13040
45. Benveniste O, Stenzel W, Hilton-Jones D, Sandri M, Boyer O, van Engelen BG. Amyloid deposits and inflammatory infiltrates in sporadic inclusion body myositis: The inflammatory egg comes before the degenerative chicken. Acta Neuropathol. 2015;129(5):611-624. doi: 10.1007/s00401-015-1384-5
46. Allenbach Y, Mammen AL, Benveniste O, Stenzel W; Immune-Mediated Necrotizing Myopathies Working Group. 224th ENMC International Workshop: Clinico-sero-pathological classification of immune-mediated necrotizing myopathies (Zandvoort, The Netherlands, 14–16 October 2016. Neuromuscul Disord. 2018;28(1):87-99. doi: 10.1016/j.nmd.2017.09.016
47. Ma X, Bu BT. Anti-SRP immune-mediated necrotizing myopathy: A critical review of current concepts. Front Immunol. 2022;13:1019972. doi: 10.3389/fimmu.2022.1019972
48. Kubínová K, Mann H, Vencovský J. MRI scoring methods used in evaluation of muscle involvement in patients with idiopathic inflammatory myopathies. Curr Opin Rheumtol. 2017;29(6):623-631. doi: 10.1097/BOR.0000000000000435
49. Antelava OA, Smirnov AV, Rapoport IE, Krasnenko SO, Khitrov AN, Nasonov EL. The use of magnetic resonance imaging for the diagnosis of muscle damage in idiopathic inflammatory myopathies. Russian Medical Journal. 2007;8:652 (In Russ.).
50. Zubair AS, Salam S, Dimachkie MM, Machado PM, Roy B. Imaging biomarkers in the idiopathic inflammatory myopathies. Front Neurol. 2023;14:1146015. doi: 10.3389/fneur.2023.1146015
51. Kobayashi I, Akioka S, Kobayashi N, Iwata N, Takezaki S, Nakaseko H, et al. Clinical practice guidance for juvenile dermatomyositis (JDM) 2018 – Update. Mod Rheumatol. 2020;30(3):411-423. doi: 10.1080/14397595.2020.1718866
52. Sultan SM, Allen E, Cooper RG, Agarwal S, Kiely P, Oddis CV, et al. Interrater reliability and aspects of validity of the myositis damage index. Ann Rheum Dis. 2011;70(7):1272-1276. doi: 10.1136/ard.2010.142117
53. Rider LG, Werth VP, Huber AM, Alexanderson H, Rao AP, Ruperto N, et al. Measures of adult and juvenile dermatomyositis, polymyositis, and inclusion body myositis: Physician and Patient/Parent Global Activity, Manual Muscle Testing (MMT), Health Assessment Questionnaire (HAQ)/Childhood Health Assessment Questionnaire (C-HAQ), Childhood Myositis Assessment Scale (CMAS), Myositis Disease Activity Assessment Tool (MDAAT), Disease Activity Score (DAS), Short Form 36 (SF-36), Child Health Questionnaire (CHQ), physician global damage, Myositis Damage Index (MDI), Quantitative Muscle Testing (QMT), Myositis Functional Index-2 (FI-2), Myositis Activities Profile (MAP), Inclusion Body Myositis Functional Rating Scale (IBMFRS), Cutaneous Dermatomyositis Disease Area and Severity Index (CDASI), Cutaneous Assessment Tool (CAT), Dermatomyositis Skin Severity Index (DSSI), Skindex, and Dermatology Life Quality Index (DLQI). Arthritis Care Res (Hoboken). 2011;63(Suppl 11):S118-S157. doi: 10.1002/acr.20532
54. Albayda J, Demonceau G, Carlier PG. Muscle imaging in myositis: MRI, US, and PET. Best Pract Res Clin Rheumatol. 2022;36(2):101765. doi: 10.1016/j.berh.2022.101765
55. Barsotti S, Zampa V, Talarico R, Minichilli F, Ortori S, Iacopetti V, et al. Thigh magnetic resonance imaging for the evaluation of disease activity in patients with idiopathic inflammatory myopathies followed in a single center. Muscle Nerve. 2016;54(4):666-672. doi: 10.1002/mus.25099
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For citations:
Kolomeychuk A.A. Capabilities of magnetic resonance imaging in the diagnosis of idiopathic inflammatory myopathies. Rheumatology Science and Practice. 2023;61(6):689-699. (In Russ.) https://doi.org/10.47360/1995-4484-2023-689-699
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