Damage to the cervical spine with rheumatoid arthritis – difficulties of dianostics and patient management
https://doi.org/10.47360/1995-4484-2025-104-111
Abstract
The article presents a description of a 73-year-old patient with rheumatoid arthritis, complicated by the development of a neurological deficit in the form of tetraparesis. Magnetic resonance imaging of the cervical spine revealed destruction of the C2 odontoid process with its replacement by a pannus, atlantoaxial subluxation, compression of the proximal segments of the spinal cord, and a compression fracture of C5.
About the Authors
E. I. ShmidtRussian Federation
Evgeniya I. Shmidt.
117049, Moscow, Leninskiy avenue, 8; 117997, Moscow, Ostrovitianova str., 1
Competing Interests:
None
A. A. Klimenko
Russian Federation
Аlesya А. Klimenko.
117997, Moscow, Ostrovitianova str., 1
Competing Interests:
None
A. V. Novikova
Russian Federation
Аnna V. Novikova.
117049, Moscow, Leninskiy avenue, 8
Competing Interests:
None
M. A. Nekrasov
Russian Federation
Mikhail А. Nekrasov.
117049, Moscow, Leninskiy avenue, 8
Competing Interests:
None
L. P. Belikova
Russian Federation
Larisa P. Belikova.
117049, Moscow, Leninskiy avenue, 8
Competing Interests:
None
A. P. Raksha
Russian Federation
Aleksander P. Raksha.
117049, Moscow, Leninskiy avenue, 8
Competing Interests:
None
V. V. Babenkov
Russian Federation
Vadim V. Babenkov.
117049, Moscow, Leninskiy avenue, 8
Competing Interests:
None
G. A. Arutyunyan
Russian Federation
Gamlet A. Arutyunyan.
117997, Moscow, Ostrovitianova str., 1
Competing Interests:
None
M. R. Mazra
Russian Federation
Marianna R. Mazra.
117997, Moscow, Ostrovitianova str., 1
Competing Interests:
None
References
1. Ferrante A, Ciccia F, Giammalva GR, Iacopino DG, Visocchi M, Macaluso F, et al. The craniovertebral junction in rheumatoid arthritis: State of the art. Acta Neurochir Suppl. 2019;125:79-86. doi: 10.1007/978-3-319-62515-7_12
2. Ding Q, Hu W, Wang R, Yang Q, Zhu M, Li M, et al. Signaling pathways in rheumatoid arthritis: Implications for targeted therapy. Signal Transduct Target Ther. 2023;8(1):68. doi: 10.1038/s41392-023-01331-9
3. Galushko EA, Nasonov EL. Prevalence of rheumatic diseases in Russia. Almanac of Clinical Medicine. 2018;46(1):32-39 (In Russ.). doi: 10.18786/2072-0505-2018-46-1-32-39
4. Joaquim AF, Ghizoni E, Tedeschi H, Appenzeller S, Riew KD. Radiological evaluation of cervical spine involvement in rheumatoid arthritis. Neurosurg Focus. 2015;38(4):E4. doi: 10.3171/2015.1.FOCUS14664
5. Kotecki M, Gasik R, Głuszko P, Sudoł-Szopińska I. Radiological evaluation of cervical spine involvement in rheumatoid arthritis: A cross-sectional retrospective study. J Clin Med. 2021;10(19):4587. doi: 10.3390/jcm10194587
6. Satybaldyev AM, Karateev DE, Smirnov AV, Oskilko TG. Injuries of the cervical spine: Description of two cases. Nauchno-Prakticheskaya Revmatologia = Rheumatology Science and Practice. 2011;49(6):70-74 (In Russ.). doi: 10.14412/1995-4484-2011-524
7. Wolfs JF, Kloppenburg M, Fehlings MG, van Tulder MW, Boers M, Peul WC. Neurologic outcome of surgical and conservative treatment of rheumatoid cervical spine subluxation: A systematic review. Arthritis Rheum. 2009;61(12):1743-1752. doi: 10.1002/art.25011
8. Castro S, Verstraete K, Mielants H, Vanderstraeten G, de Reuck J, Veys EM. Cervical spine involvement in rheumatoid arthritis: A clinical, neurological and radiological evaluation. Clin Exp Rheumatol. 1994;12(4):369-374.
9. Nguyen HV, Ludwig SC, Silber J, Gelb DE, Anderson PA, Frank L, et al. Rheumatoid arthritis of the cervical spine. Spine J. 2004;4(3):329-334. doi: 10.1016/j.spinee.2003.10.006
10. Boden SD, Dodge LD, Bohlman HH, Rechtine GR. Rheumatoid arthritis of the cervical spine. A long-term analysis with predictors of paralysis and recovery. J Bone Joint Surg Am. 1993;75(9):1282-1297. doi: 10.2106/00004623-199309000-00004
11. Syniachenko OV, Selezniova SV, Perepada HV, Yehudina YeD, Sokrut OP, Geyko IA. Lesion of the spine in rheumatoid arthritis. Pain. Joints. Spine. 2016;1(21):40-44 (In Russ.).
12. Polishchuk NE, Korzh NA, Fishchenko VYa (comp.). Damage to the spine and spinal cord. Kyiv:KNIGA plus;2001 (In Russ.).
13. Wasserman BR, Moskovich R, Razi AE. Rheumatoid arthritis of the cervical spine – Clinical considerations. Bull NYU Hosp Jt Dis. 2011;69(2):136-148.
14. Oostveen JC, van de Laar MA, Geelen JA, de Graaff R. Successful conservative treatment of rheumatoid subaxial subluxation resulting in improvement of myelopathy, reduction of subluxation, and stabilisation of the cervical spine. A report of two cases. Ann Rheum Dis. 1999;58(2):126-129. doi: 10.1136/ard.58.2.126
15. Siempis T, Tsakiris C, Anastasia Z, Alexiou GA, Voulgaris S, Argyropoulou MI. Radiological assessment and surgical management of cervical spine involvement in patients with rheumatoid arthritis. Rheumatol Int. 2023;43(2):195-208. doi: 10.1007/s00296-022-05239-5
16. Paus AC, Steen H, Røislien J, Mowinckel P, Teigland J. High mortality rate in rheumatoid arthritis with subluxation of the cervical spine: A cohort study of operated and nonoperated patients. Spine (Phila Pa 1976). 2008;33(21):2278-2283. doi: 10.1097/BRS.0b013e31817f1a17
17. Ranawat CS, O’Leary P, Pellicci P, Tsairis P, Marchisello P, Dorr L. Cervical spine fusion in rheumatoid arthritis. J Bone Joint Surg Am. 1979;61(7):1003-1010.
18. Joaquim AF, Appenzeller S. Cervical spine involvement in rheumatoid arthritis – A systematic review. Autoimmun Rev. 2014; 13(12):1195-202. doi: 10.1016/j.autrev.2014.08.014
Review
For citations:
Shmidt E.I., Klimenko A.A., Novikova A.V., Nekrasov M.A., Belikova L.P., Raksha A.P., Babenkov V.V., Arutyunyan G.A., Mazra M.R. Damage to the cervical spine with rheumatoid arthritis – difficulties of dianostics and patient management. Rheumatology Science and Practice. 2025;63(1):104-111. (In Russ.) https://doi.org/10.47360/1995-4484-2025-104-111