Mineral bone density association with estrogen alpha receptor gene (ESRa) polymorphisms at postmenopausal osteoporosis
https://doi.org/10.14412/1995-4484-2005-548
Abstract
Objective. To study restrict fragment length polymorphisms (RFLP) Pvull and Xbal of estrogen gene (EG) receptor sites and its association with bone mineral density (BMD). Material and methods. 96 female with osteoporosis (OP) and 60 female without OP of comparable postmenopausal age (55-83 years) were included. Results. Statistically significant differences of Pvull genotypes frequencies prevalence between women with OP and control group so as absence of differences of Xbal genotypes frequencies prevalence were shown (p<0,05). Similar results were shown for combined genotypes PvuII/Xbal. Genotype ppxx in pts with OP was 3 times more frequent than in control group (29,2% and 10,0% respectively, p<0,05). Among pts with PP genotype mean spine BMD value came to 0,686±0,064 g/cm- and was significantly less (p<0,05) in comparison with Pp and pp genotypes (073310,073 g/cm 2 and 0,739±0,099 g/cm 2 respectively). Mean spine BMD value in pts with PPXx genotype was significantly less than in pts with ppxx genotype (0,66710,076 and 0,74410,102 g/cm2 respectively, p<0,05) and mean femoral neck BMD value in pts with the same genotype (PPXx) was significantly less than in pts with PpXx genotype (0,57710,079 and 0,62710,054 g/cm 2 respectively. Conclusion. We have confirmed that some EG genotypes and their combinations are associated with low spine and femoral neck BMD values in pts with OP.
About the Authors
M Y KrylovA. V. Grechenko
E Y Samarkina
N V Toroptsova
T A Korotkova
O A Nikitinskaya
V A Myakotkin
L I Benevolenskaya
References
1. <div><p>Bagger Y.Z., Jorgensen H.L., Heegaard A.M. et at. No 14. major effect of esirogen receptor polymorphisms on bone mineral density or bone loss in postmenopausal Danish women. Bone, 2000, 26,111-116. 15.</p><p>Becherini L. Gennari L., Connelli S. et at. Estrogen - receptor - alpha gene polymorphism and osteoporosis: A large scale study on postmenopausal women. Bone, 1998, 16. 23, 5 (suppl.), S 269.</p><p>Bord S., Homer A., Beavan S., Compston J. Estrogen receptors alpha and beta differentially expressed in developing human bone. J. Clin. Endocr. Metab., 2001, 86,2309 17. - 2314.</p><p>Eisman J.A. Vitamin D receptor gene alleles and osteoporosis: an affirmative view [editorial], J. Bone Miner. Res., 18. 1995, 10,1289-1293.</p><p>Eriksen E.F., Colvard D.S., Berg N.J. et at. Evidence of estrogen receptors in normal human osteoblast-like cells. Science, 1988, 241,84-86. 19.</p><p>Gennari L., Becherini L., Masi L. et at. Vitamin D and estrogen receptor allelic variants in postmenopausal women: evidence of multiple gene contribution on bone mineral 20. density. Clin. Endocrinol. Metab., 1998, 83,939-944.</p><p>Han K.O., Moon I.G., Kang Y.S. et at. Non association of 21. estrogen receptor genotypes with bone mineral density and estrogen responsiveness to hormone replacement therapy in Korean postmenopausal women. J. Clin. Endocrinol. Metab., 1997, 82,99-105. 22.</p><p>Ho A.Y., Yeung S.S., Kung A.W. Pvull polymorphisms of the estrogen receptor gene alpha and bone mineral density in healthy Southern Chinese women. Calcif. Tissue Int., 2000, 66,405-408. 23.</p><p>Houston L.A., Grant S.F., Reid D.M., Ralston S.H. Vitamin D receptor polymorphism, bone mineral density, and osteoporotic vertebral fracture: studies in a UK population. Bone, 1996, 18,249-252.</p><p>Hustmayer F.G., Peacock М., Hui S. et al. Bone mineral 24. density in relation to polymorphism at the vitamin D receptor gene locus. J. Clin. Invest., 1994, 94,2130-2134.</p><p>Kobayashi S., Inoue S., Hosoi T. et al. Association of bone 25. mineral density with polymorphism of estrogen receptor gene. J. Bone Miner. Res., 1996, 11,306-311.</p><p>Korach K.S. Insights from the study of animals lacking functional estrogen receptor. Science, 1994, 266,1524-1527. 26.</p><p>Lindsay R., Aitken J.M., Anderson J.B. et al. Long-term prevention of postmenopausal osteoporosis by estrogen: evidence for an increased bone mass after delayed onset estrogen treatment. Lancet, 1976, 1,1038-1041.</p><p>Lufltin E.G., Carpenter P.C., Ory S.J. et al. Estrogen replacement therapy: current recommendations. Mayo Clin. Proc., 1988, 63,453-460.</p><p>Morrison N.A., Qi J.C., Tokita A., Kelly P.J. et al. Prediction of bone density from vitamin D receptor alleles. Nature, 1994, 367,284-287.</p><p>Peacock М., Hustmyer F.G., Hui S. et al. Vitamin D receptor genotype and bone mineral density. Evidence conflicts on link [letter; comment]. Br. Med. J., 1995, 311,874875.</p><p>Peacock M. Vitamin D receptor gene alleles and osteoporosis: a contrasting view [editorial], J. Bone Miner. Res., 1995, 10,1294-1297.</p><p>Pensier J.M., Radosevich J.A., Higbee R., Langman C.B. Osteoclasts isolated from membranous bone in children exhibit nuclear estrogen and progesterone receptors. J. Bone Miner. Res., 1990, 5,797-802.</p><p>Pocock N.A., Eisman J.A., Hopper J.L. et al. Genetic determinants of bone mass in adult. A twin study. J. Clin. Invest., 1987, 80,706-710.</p><p>Riggs B.L., Melton L.J, III. Involutional osteoporosis. New Engl. J. Med., 1986, 314,1676-1686.</p><p>Salamone L.M., Ferrell R.t Black D.M. et al. The association between vitamin D receptor gene polymorphisms and bone mineral density at the spine, hip and whole-body in premenopausal women. Osteoporos. Int., 1996, 6,63-68.</p><p>Sano М., Inoue S., Hosoi T. et al. Association of estrogen receptor dinucleotide repeat polymorphism with osteoporosis. Biochem. Biophys, Res. Commun., 1995, 217,378383.</p><p>Slemenda C.W., Christian J.C., Williams C.J. et al. Genetic determinants of bone mass in adult women: a reevaluation of the twin model and the potential importance of gene interaction on heritability estimates. J. Bone Miner. Res., 1991, 6, 561-567.</p><p>Smith E.P., Boyod J., Frank G.R. et al. Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man. N. Engl. J. Med., 1994, 331,1056-1061.</p><p>Uitteriinden A.G., Pols HA., Burger H. etal. A large-scale population-based study of the association of vitamin D receptor gene polymorphisms with bone mineral density. J. Bone Miner. Res., 1996, 11,1241-1248.</p><p>Willing М., Sowers М., Aron D. et al. Bone mineral density and its change in white women: estrogen and vitamin D receptor genotypes and their interaction. J. Bone Miner. Res. 1998, 13.695-705.</p></div><br />
Review
For citations:
Krylov M.Y., Grechenko A.V., Samarkina E.Y., Toroptsova N.V., Korotkova T.A., Nikitinskaya O.A., Myakotkin V.A., Benevolenskaya L.I. Mineral bone density association with estrogen alpha receptor gene (ESRa) polymorphisms at postmenopausal osteoporosis. Rheumatology Science and Practice. 2005;43(1):8-11. (In Russ.) https://doi.org/10.14412/1995-4484-2005-548
Views:
857
Email this article 