ПРОБЛЕМЫ ЭПИГЕНОМА ПРИ РЕВМАТОИДНОМ АРТРИТЕ
https://doi.org/10.14412/1995-4484-2011-566
Аннотация
Ревматоидный артрит (РА), будучи ярким представителем большого семейства аутоиммунных заболеваний, во многом остается еще далеко не до конца изученным заболеванием. Это касается этиологии и патогенеза, а также эффективных подходов к его лечению. В обзоре представлены литературные данные о роли эпигеномных механизмов регуляции функционирования генов как в иммунокомпетентных клетках, так в синовиальных фибробластах - основных мишенях действия аутоиммунных клеток. Наличие у больных РА нескольких источников гипометилированной ДНК дает возможность говорить о значительном вкладе этих молекул в патогенез заболевания. Кроме того, обнаруженное гиперметилирование отдельных генов, помимо патогенетического значения данного феномена, может быть использовано при разработке новых подходов к лечению РА, основанных на процессах деметилирования этих генов.
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Рецензия
Для цитирования:
Kozlov V.A. ПРОБЛЕМЫ ЭПИГЕНОМА ПРИ РЕВМАТОИДНОМ АРТРИТЕ. Научно-практическая ревматология. 2011;49(3):9-13. https://doi.org/10.14412/1995-4484-2011-566
For citation:
Kozlov V.A. PROBLEMS OF EPIGENOME IN RHEUMATOID ARTHRITIS. Rheumatology Science and Practice. 2011;49(3):9-13. (In Russ.) https://doi.org/10.14412/1995-4484-2011-566
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