BONE MINERAL DENSITY IN MALES WITH DIFFERENT CLINICAL TYPES OF RHEUMATOID ARTHRITIS
https://doi.org/10.14412/1995-4484-2011-598
Abstract
Objective: to estimate bone mineral density (BMD) in males with different clinical types of rheumatoid arthritis (RA). Subjects and methods. The study enrolled 80 patients having a valid diagnosis of RA (mean age 55.2±1.4 years; disease duration 7.2±0.6 years). A control group included 84 apparently healthy men matched for age (56.7±0.9 years). BMD was measured by dual-energy X-ray absorptiometry using a stationary Exceell XR-46 bone densitometer (Norland, USA).
Results. In the patients with RA, the BMD values in both the femoral neck and lumbar spine were significantly lower than those in the control group. Thus, the males with RA had a femoral neck BMD of 924.66±14.03 g/cm2, which is equal to 2.34±0.10 standard deviations (SD) as evidenced by the T-test, while the control group had this index of 1007.85±16.84 g/cm2, which is equal to 1.54±0.12 SD as shown by the T-test (p<0.001 and p<0.001). In the study group, the lumbar spine BMD was 1045.51±21.89 g/cm2, which is equal to -1.15±0.12 SD as indicated by the T-test, and in the control group that was 1123.19±19.74 g/cm2, which is equal to -0.65±0.10 SD as evidenced by the T-test (p = 0.006 and p<0.001). The highest risk of osteoporosis was noted with high RA activity, X-ray stages III-IV, and Functional Class III-IV.
Discussion. The presence of RA in males negatively affects BMD, but enhanced activity, higher X-ray stage and functional class are additional risk factors for BMD reduction, which are associated with the disease itself.
Results. In the patients with RA, the BMD values in both the femoral neck and lumbar spine were significantly lower than those in the control group. Thus, the males with RA had a femoral neck BMD of 924.66±14.03 g/cm2, which is equal to 2.34±0.10 standard deviations (SD) as evidenced by the T-test, while the control group had this index of 1007.85±16.84 g/cm2, which is equal to 1.54±0.12 SD as shown by the T-test (p<0.001 and p<0.001). In the study group, the lumbar spine BMD was 1045.51±21.89 g/cm2, which is equal to -1.15±0.12 SD as indicated by the T-test, and in the control group that was 1123.19±19.74 g/cm2, which is equal to -0.65±0.10 SD as evidenced by the T-test (p = 0.006 and p<0.001). The highest risk of osteoporosis was noted with high RA activity, X-ray stages III-IV, and Functional Class III-IV.
Discussion. The presence of RA in males negatively affects BMD, but enhanced activity, higher X-ray stage and functional class are additional risk factors for BMD reduction, which are associated with the disease itself.
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For citations:
Raskina T.A., Letaeva M.V., Raskina T.A., Letayeva M.V. BONE MINERAL DENSITY IN MALES WITH DIFFERENT CLINICAL TYPES OF RHEUMATOID ARTHRITIS. Rheumatology Science and Practice. 2011;49(2):21-24. (In Russ.) https://doi.org/10.14412/1995-4484-2011-598
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