NSAID-INDUCED GASTROPATHIES IN CHILDREN WITH RHEUMATIC DISEASES: DIAGNOSTICS AND TREATMENT
https://doi.org/10.14412/1995-4484-2000-786
Abstract
168 patients aged 4-15 years were endoscopically examined aiming at the study of prevalence and structure of NSAID - gustropathy in children with rheumatic diseases. Serious injury of mucous of upper gastrointestinal tract (erosions and ulcers) were found in 21% of children with prevalent localization in the region of the bulb of duodenum and in 50% ofpatients surface changes were revealed. In the group under study there were no reliable dependence between the degree of subjective and objective symptoms of NSAID - gustropathy and no associations of peculiarities of endoscopic changes with the character and duration of medicamentong therapy. The experience of Famotidin using ( Famosan, Pro.Med.CS. Praha c.s.) in 40 children with most pronounced manifestations of drug-induced gastroduodenopathies demonstrated its high efficacy, manifested in quick ceasing of complaints in all patients, healing of erosions and ulcers in great majority of patients with absence of side-ejfects.
References
1. <div><p>Каратеев А.Е, Насонова В.А, Муравьев Ю.В. Оценка влияния ГКС и НПВП на слизистую ЖКТ у больных ревматическими заболеваниями. Тер. архив, 1999, 2, 34-39.</p><p>Шахбазян И.Е, Гаркуша М.Б., Склянская О.А, Али Н.Ю., Даурова Н.В, Чумакова А.М., Секамова С.М., Жуховицкая В.Г., Уфимце- ва А.Г. Гастродуоденит Campylobacter pylori у детей, больных ювенильным ревматоидным артритом. Ревматология, 1991, 3, 23-28.</p><p>Agrawal N.M. Epidemiology and preventoon of non-steroidal antiinflammatory drug effects in the gastrointestinal tract. British. J. Rheumatol., 1995, 34, suppl., 1, 5-10.</p><p>Dowd J.E., Cimaz R., Fink C.W. Nonsteroidal antiinflammatory drug-indused gastroguodenal injury in children. Arthr. Rheum.,38/1995, 9, 1225-1231.</p><p>Fries J. Non-steroidal anti-inflammatory drug safety: a view from the ARAMIS databank. Curr. p. rheumat, 1996, 9, suppl. 1,3-7.</p><p>Furst D.E. Toxity of antirheumatic medications in children with juvenile arthritis. /J. Rheumatol. 1992, 19, suppl. 33, 11-15.</p><p>Hawkey C.J. Non-steroidal anti-inflammatory drug gastropathy: causes and treatment. Scand J. Gastroenterol Suppl. 1996, 220, p. 124-127.</p><p>Hermaszewski R., Hayller J. Pediatric rheumatology: Original paper gastroduodenal damage due to non-steroidal anti-inflammatory drugs in children. Br. J. Rheumatol. 1993, 21/1, 69-72.</p><p>Hollingworth P. The use of non-steroidal antiinflammatory drugs in paediatric rheumatic diseases. Br. J. Rheumatol. 1993, 21/1, 73-77.</p><p>Lancaster-Smith M.J., Jaderberg M.E., Jackson D.A. Ranitidine in the treatment of nonsteroidal anti-inflammatory drug associated gastric and duodenal ulcers. Gut, 1991, 32, 252255.</p><p>Tildesley G., Ensanullah R.S.B. and Wood J.R. Ranitidine in the treatment of gastric and duodenal ulcers associated with non-steroidal anti-inflammatory drugs. /Br. J. Rheumatol. 1993, 32/ 6, 474-478.</p></div><br />
Review
For citations:
Nikishina P.I., Kuzmina N.N., Karateyev A.E. NSAID-INDUCED GASTROPATHIES IN CHILDREN WITH RHEUMATIC DISEASES: DIAGNOSTICS AND TREATMENT. Rheumatology Science and Practice. 2000;38(1):42-48. (In Russ.) https://doi.org/10.14412/1995-4484-2000-786
Views:
856
Email this article 