Кардиоваскулярные факторы риска и толщина комплекса интима -медиа у женщин репродуктивного возраста, больных ревматоидным артритом

Аннотация

Objective. To determine frequency and significance of traditional risk factors of cardiovascular pathology development and to assess features of carotids atherosclerotic damage in women of reproductive age with rheumatoid arthritis (RA). Material and methods. 85 women with RA (mean age 42,1±6,8 years) and 32 healthy women (mean age 43,2±6,7 years) were included. Traditional risk factors of cardiovascular diseases (CVD) were examined. Blood lipid spectrum was assessed by content of total cholesterol (CTC), triglycerides (TG) and high density lipoprotein cholesterol (HDLC). Low density lipoprotein cholesterol (LDLC) and atherogenity index (AI) were calculated. To reveal subclinical forms of atherosclerosis common carotid arteries (CCA) duplex scanning with measurement of intima-media complex (IMC) was performed using ultrasound system “Acuson 128/XP10” (USA) by linear sensor with 7 MHz frequency. C- reactive protein (CRP) was assessed by immuno-enzyme assay. Results. Hypertension and lipid metabolism disturbance were the most prevalent risk factors of development and progression of CVD in women of reproductive age with RA. Subclinical atherosclerosis characterized by thickening of IMC was more frequent in RA pts than in healthy women (p<0,001). Presence of extra-articular RA manifestations was accompanied by significant IMC thickening in the region of carotid artery bulb and internal carotid artery (p<0,001, p=0,003). Carotid artery IMC was significantly increased at 3rd RA activity degree in comparison with 1st activity degree (p=0,016) and in the presence of rheumatoid factor in serum (p=0,026). RA pts had IMC thickening irrespectively from CVD history. Conclusion. RA activity as well as HDLC, LDLC and CRP concentration are predictors of vascular atherosclerotic damage in RA