Material and methods. 1300 pts aged 18 to 50 years actively visited out-patients’ clinic №17 of South Administrative District were examined during a month with a questionnaire developed in the Institute of Rheumatology of RAMS. Results. LBP is a frequent cause of pt visits in outpatient practice. Spine X-ray was the most frequent diagnostic method used in such cases. Spine osteochondrosis was the most frequent diagnosis in these pts. Frequency of “red flags” did not exceed 10%.

A.P. Rebrov, E.l. Koshkina, A.A. Antonyan, R.V. Lyakisheva NSAID-induced gastro-duodenal bleeding: risk of development and patient management. Retrospective analysis of gastro-duodenal bleeding (GDB) report forms was performed. Pts admitted to the department of internal diseases of Saratov regional clinical hospital from 1999 to 2004 were included. 354 cases of GDB were recorded ( 282 from 1999 to 2001 and 72 from 2002 to 2004). Cause ofbleeding, influence of NSAID administration on appearance and relapse ofbleeding, source ofbleeding and pt management were assessed. NSAJD administration was considered trigger factor of GDB in 24% in 1999-2001 and in 18% in 2002-2004. The results of the study show some tendency to decrease of NSAID- induced gastropathy frequency among causes of GDB. The main risk factors ofbleeding during NSAID treatment were age of more than 30 years, ulcer history, the first month of NSAID administration. GDB frequency did not depend on regularity of treatment and NSAID dosage.

Objective. To study state of immune status in children and adolescents with juvenile idiopathic arthritis (JIA) at early stages of the disease development and perspectives of their treatment. Materials and methods. 286 children and adolescents with olygo- and polyarticular variants of JIA aged 3 to 18 years were included. Examination of CD4, CD8, CD16, CD95 lymphocyte markers, IgA, IgG, IgM rheumatoid factor, interleukin 1(3, 4, 6, 8, 10, tumor necrosis factor a as well as lymphocyte morphometry was performed. Results. High blood levels of CD4, CD8, CD 16, CD95, pro- and anti- inflammatory interleukins were revealed at active stage of JIA particularly in pts with polyarthritis and extended olygoarthritis. Changes of mean lymphocyte morphometric measures linearly inversely correlated with relative lymphocyte markers level what proves relationship of processes of proliferation, cytotoxicity and elevation of circulating apoptotic cell count in blood. However increase of “programmed death cells" may reflect not only proliferation but also capability of cells to induce cell death program in presence of provocative factors. In pts with very high humoral level of lymphocyte markers and cytokines appropriate therapy more often induces clinico-laboratory remission than in pts with lower values. Conclusion. Immune and cytokine status in children and adolescents with JIA determines evolution of arthritis. Early administration of disease modifying drugs more often induces of clinico-laboratory remission in pts with high levels of lymphocyte markers and antiinflammatory cytokines.