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Characteristic of microcirculatory changes in patients with primary Raynod's phenomenon by videocapillaroscopy

https://doi.org/10.14412/1995-4484-2003-1352

Abstract

Objective. To study prevalence and structure of videocapillaroscopic findings in primary Raynaud's phenomenon (PRP) and their relation to clinical picture. Methods. 20 pts with PRP and 15 controls were examined by videocapillaroscopy. Results. The presence of homogenous enlarged (mean loop diameter 33,6±7,7 m, p<0,0005) and elongated (mean loop length 301±109 m, p<0,0005) capillaries, multiple punctate hemorrhages or confluent areas of hemorrhage was characteristic of PRP group. Nonspecific capillary changes often found in PRP consisted of tortuous venular part (50%), bushy capillaries (20%). isolated punctate hemorrhages (19%), increased visibility of subpapillary venous plexus (20%). The prevalence of cyanosis in clinical picture of PRP was accompanied by considerable enlargement of venular parts of the loops, prominence of subpapillary vessels, minor dystrophies (tortuous, bushy capillaries) were more frequently seen in pts with longer disease duration. Conclusion. PRP is characterized by structural capillary changes which must be taken into consideration in diagnosis and differential diagnosis of primary and secondary Raynaud's phenomenon.

References

1. <div><p>Anders H.J., Sigl Т., Schattenkirchner М. Differentiation between primary and secondary Raynaud's phenomenon: a prospective study comparing nailfold capillaroscopy using an ophtalmoscope or stereomicroscope. Ann.Rheum.Dis., 2001, 60(4). 407-409.</p><p>Bedarida G. Kim D., Blaschke T.F., Hoffman B.B. Venodilation in Ravnaud's disease. Lancet, 1993, 342, 1451-1454.</p><p>Belch J.J.F. Raynaud's phenomenon: its relevance to scleroderma. Ann.Rlieum.Dis., 1991, 50, 839-845.</p><p>Bierbrauer A.F.G., Mennel H.D., Schmidt J.A. Wichert P. Intravital microscopy and capillaroscopically guided nail fold biopsy in sceroderma. Ann.Rheum. Dis., 1996, 55, 305310.</p><p>Binaghi F., Cannas F. Mathieu A., Pitzus F. Correlation among capillaroscopic abnormalities, digital flow and immunologic findings in patients with isolated Raynaud's phenomenon. Intern.Angiol., 1992, II, 186-194.</p><p>Blockmans D., Beyens G., Verhaeghe R. Predictive value of nailfold capillaroscopy in the diagnosis of connective tissue diseases. Clin.Rheumatol., 1996, 15 (2), 148-153.</p><p>Brennan P., Silman A., Black C. et al. Validity and reliability of three methods used in the diagnosis of Raynaud's phenomenon Br.J. Rheum., 1993, 32, 357-361.</p><p>Bukhari М., Herrick A.L., Moore T. et al. Increased nailfold capillary dimension in primary Raynaud's phenomenon and systemic sclerosis. Br.J.Rheum., 1996, 35, 1127-1131.</p><p>Bukhari М., Hollis S., Moore Т., et al. Quantitation of microcirculatory abnormalities in patients with primary Raynaud’s phenomenon and systemic sclerosis by video capillaroscopy. Rheumatol., 2000, 39, 506-512.</p><p>Carpentier P.H., Maricq H.R. Microvasculature in systemic sclerosis. Rheum.Dis.Clin.North.Am., 1990, 16, 75-91.</p><p>Currey J., Newland B. Nailfold capillary microscopy in patients with Raynaud's phenomenon: experience in a district General Hospital. Br.J.Rheumatol., 1998, 37(5), 383.</p><p>Houtman P.M., Kallenberg C.G.M., Fidler V., Wouda A.A.Diagnostic significance of nailfold capillary patterns in patients with Raynaud's phenomenon. J. Rheumatol., 1986, 13(3),556-563.</p><p>Isenberg D.A., Black C. Raynaud's phenomenon, scleroderma. and overlap syndromes. BMJ, 1995, 310. 795-798.</p><p>Kabasakal Y. Elvis D M., Ring E.F., WcHugh N.J. Quantitative nailfold capillaroscopy findings in a population with connective tissue disease and in normal healthy controls. Ann.Rheum.Dis., 1996, 55, 507-512.</p><p>Kulka J.P. Microcirculatory impairment as a factor in inflammatory tissue damage. Ann.N.Y.Acad.Sci. 1946, 116, 1018-1041.</p><p>Lee P., Sarkozi J., Bookman A.A. et al. Digital blood flow and nailfold capillary microscopy in Raynaud's phenomenon. J.Rheumatol., 1986, 13, 564-569.</p><p>Maricq H.R., Harper F.E., Tan E.M., LeRoy E.C. Microvascular abnormalities as possible predictors of disease subsets in Raynaud's phenomenon and early connective tissue disease. Clin.Exp.Rhcumato!., 1983, 1, 195-205.</p><p>Maricq H.R. Widefield capillary microscopy. Arthr.Rheum., 1981, 24(9), 1159-1165.</p><p>Scheja A., Akesson A., Niewierowick I,, et al. Computer based quantitative analysis of capillary abnormalities in systemic sclerosis and its relation to plasma concentration of von Willebrand factor. Ann.Rheum. Dis., 1996, 55, 52-56.</p><p>Statham B.N., Rowell N.R. Quantification of the nail fold capillary abnormalities in systemic sclerosis and Raynaud's syndrome. Acta Dermatol. Venerol., (Stockholm), 1986, 66, 139-143.</p><p>Wong M.L., Highton J., Palmer D.G. Sequential nailfold capillary microscopy in scleroderma and related disorders. Ann. Rheum.Dis., 1998. 47, 53-61.</p><p>Zufferey P., Depairon М., Chamot A.M., Monti M. Prognostic significance of nailfold capillary microscopy in patients with Raynaud's phenomenon and scleroderma-pat- tem abnormalities. A six-year follow-up study. Clin. Rheumatol., 1992, 11(4), 536-541.</p></div><br />


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Nevskaya T.A., Guseva N.G. Characteristic of microcirculatory changes in patients with primary Raynod's phenomenon by videocapillaroscopy. Rheumatology Science and Practice. 2003;41(3):11-15. (In Russ.) https://doi.org/10.14412/1995-4484-2003-1352

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ISSN 1995-4484 (Print)
ISSN 1995-4492 (Online)