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Научно-практическая ревматология

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Роль Toll-подобных рецепторов и их эндогенных лигандов в патогенезе ревматоидного артрита (обзор литературы)

https://doi.org/10.14412/1995-4484-2016-78-85

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Аннотация

Несмотря на большие достижения в изучении патогенеза ревматоидного артрита (РА), позволившие создать принципиально новый класс фундаментально обоснованных терапевтических агентов, многие иммунологические аспекты остаются не до конца изученными. Одним из важных вопросов патогенеза не только РА, но и всех ревматических заболеваний является роль механизмов врожденного иммунитета в развитии аутоиммунного воспаления. Открытие паттерн-распознающих рецепторов (ПРР) позволило фундаментальной иммунологии сделать большой шаг вперед в понимании того, каким образом реализуются данные механизмы. Изучение мембранных и эндосомальных Toll-подобных рецепторов (ТПР) – наиболее обширной и хорошо изученной группы ПРР – является перспективным направлением современной ревматологии. Важно отметить, что стимулировать ТПР способны некоторые молекулярные агенты, присутствие которых в ткани ассоциировано с ее повреждением. Они получили название молекулярных паттернов, ассоциированных с повреждением (МПАП). В статье представлен обзор литературы, посвященной механизмам реализации ТПР-опосредованных сигнальных путей, различным аспектам роли отдельных ТПР и МПАП в индукции и поддержании аутоиммунного воспаления при РА, а также перспективам таргетной терапии, направленной на ингибирование некоторых ТПР и МПАП.

Об авторе

М. Ю. Волков
ФГБНУ Научно-исследовательский институт ревматологии им. В.А. Насоновой
Россия
Москва, 115522 Москва, Каширское шоссе, 34А


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Для цитирования:


Волков М.Ю. Роль Toll-подобных рецепторов и их эндогенных лигандов в патогенезе ревматоидного артрита (обзор литературы). Научно-практическая ревматология. 2016;54(1):78-85. https://doi.org/10.14412/1995-4484-2016-78-85

For citation:


Volkov M.Yu. ROLE OF TOLL-LIKE RECEPTORS AND THEIR ENDOGENOUS LIGANDS IN THE PATHOGENESIS OF RHEUMATOID ARTHRITIS: A REVIEW OF LITERATURE. Rheumatology Science and Practice. 2016;54(1):78-85. (In Russ.) https://doi.org/10.14412/1995-4484-2016-78-85

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ISSN 1995-4484 (Print)
ISSN 1995-4492 (Online)